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Protein

Macrophage-expressed gene 1 protein

Gene

MPEG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31458-MONOMER.

Protein family/group databases

TCDBi1.C.39.14.1. the membrane attack complex/perforin (macpf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage-expressed gene 1 protein
Short name:
Macrophage gene 1 protein
Short name:
Mpg-1
Gene namesi
Name:MPEG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29619. MPEG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 655ExtracellularSequence analysisAdd BLAST631
Transmembranei656 – 676HelicalSequence analysisAdd BLAST21
Topological domaini677 – 716CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi219972.
OpenTargetsiENSG00000197629.
PharmGKBiPA164723088.

Chemistry databases

ChEMBLiCHEMBL3414409.

Polymorphism and mutation databases

BioMutaiMPEG1.
DMDMi121941470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000032414325 – 716Macrophage-expressed gene 1 proteinAdd BLAST692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ2M385.
PaxDbiQ2M385.
PeptideAtlasiQ2M385.
PRIDEiQ2M385.

PTM databases

iPTMnetiQ2M385.
PhosphoSitePlusiQ2M385.

Expressioni

Tissue specificityi

Expressed in macrophages and peripheral blood monocytes.1 Publication

Gene expression databases

BgeeiENSG00000197629.
GenevisibleiQ2M385. HS.

Organism-specific databases

HPAiHPA046801.

Interactioni

Protein-protein interaction databases

BioGridi128608. 2 interactors.
IntActiQ2M385. 3 interactors.
STRINGi9606.ENSP00000354335.

Chemistry databases

BindingDBiQ2M385.

Structurei

3D structure databases

ProteinModelPortaliQ2M385.
SMRiQ2M385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 345MACPFPROSITE-ProRule annotationAdd BLAST316

Sequence similaritiesi

Contains 1 MACPF domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IER6. Eukaryota.
ENOG410ZMVS. LUCA.
GeneTreeiENSGT00390000008048.
HOGENOMiHOG000024828.
HOVERGENiHBG057416.
InParanoidiQ2M385.
OMAiRPPLMSQ.
OrthoDBiEOG091G027S.
PhylomeDBiQ2M385.
TreeFamiTF331165.

Family and domain databases

InterProiIPR020864. MACPF.
[Graphical view]
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
PROSITEiPS51412. MACPF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2M385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFRATILF WAAAAWAKSG KPSGEMDEVG VQKCKNALKL PVLEVLPGGG
60 70 80 90 100
WDNLRNVDMG RVMELTYSNC RTTEDGQYII PDEIFTIPQK QSNLEMNSEI
110 120 130 140 150
LESWANYQSS TSYSINTELS LFSKVNGKFS TEFQRMKTLQ VKDQAITTRV
160 170 180 190 200
QVRNLVYTVK INPTLELSSG FRKELLDISD RLENNQTRMA TYLAELLVLN
210 220 230 240 250
YGTHVTTSVD AGAALIQEDH LRASFLQDSQ SSRSAVTASA GLAFQNTVNF
260 270 280 290 300
KFEENYTSQN VLTKSYLSNR TNSRVQSIGG VPFYPGITLQ AWQQGITNHL
310 320 330 340 350
VAIDRSGLPL HFFINPNMLP DLPGPLVKKV SKTVETAVKR YYTFNTYPGC
360 370 380 390 400
TDLNSPNFNF QANTDDGSCE GKMTNFSFGG VYQECTQLSG NRDVLLCQKL
410 420 430 440 450
EQKNPLTGDF SCPSGYSPVH LLSQIHEEGY NHLECHRKCT LLVFCKTVCE
460 470 480 490 500
DVFQVAKAEF RAFWCVASSQ VPENSGLLFG GLFSSKSINP MTNAQSCPAG
510 520 530 540 550
YFPLRLFENL KVCVSQDYEL GSRFAVPFGG FFSCTVGNPL VDPAISRDLG
560 570 580 590 600
APSLKKCPGG FSQHPALISD GCQVSYCVKS GLFTGGSLPP ARLPPFTRPP
610 620 630 640 650
LMSQAATNTV IVTNSENARS WIKDSQTHQW RLGEPIELRR AMNVIHGDGG
660 670 680 690 700
GLSGGAAAGV TVGVTTILAV VITLAIYGTR KFKKKAYQAI EERQSLVPGT
710
AATGDTTYQE QGQSPA
Length:716
Mass (Da):78,587
Last modified:February 21, 2006 - v1
Checksum:iC863E3AF2029A0AA
GO

Sequence cautioni

The sequence BAB84992 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051200467A → T.Corresponds to variant rs544864dbSNPEnsembl.1
Natural variantiVAR_051201552P → L.1 PublicationCorresponds to variant rs7926933dbSNPEnsembl.1
Natural variantiVAR_051202694Q → R.Corresponds to variant rs17153442dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074166 mRNA. Translation: BAB84992.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73839.1.
BC104997 mRNA. Translation: AAI04998.1.
BC112230 mRNA. Translation: AAI12231.1.
CCDSiCCDS41650.1.
RefSeqiNP_001034485.1. NM_001039396.1.
UniGeneiHs.744920.

Genome annotation databases

EnsembliENST00000361050; ENSP00000354335; ENSG00000197629.
GeneIDi219972.
KEGGihsa:219972.
UCSCiuc001nnu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074166 mRNA. Translation: BAB84992.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73839.1.
BC104997 mRNA. Translation: AAI04998.1.
BC112230 mRNA. Translation: AAI12231.1.
CCDSiCCDS41650.1.
RefSeqiNP_001034485.1. NM_001039396.1.
UniGeneiHs.744920.

3D structure databases

ProteinModelPortaliQ2M385.
SMRiQ2M385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128608. 2 interactors.
IntActiQ2M385. 3 interactors.
STRINGi9606.ENSP00000354335.

Chemistry databases

BindingDBiQ2M385.
ChEMBLiCHEMBL3414409.

Protein family/group databases

TCDBi1.C.39.14.1. the membrane attack complex/perforin (macpf) family.

PTM databases

iPTMnetiQ2M385.
PhosphoSitePlusiQ2M385.

Polymorphism and mutation databases

BioMutaiMPEG1.
DMDMi121941470.

Proteomic databases

MaxQBiQ2M385.
PaxDbiQ2M385.
PeptideAtlasiQ2M385.
PRIDEiQ2M385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361050; ENSP00000354335; ENSG00000197629.
GeneIDi219972.
KEGGihsa:219972.
UCSCiuc001nnu.5. human.

Organism-specific databases

CTDi219972.
DisGeNETi219972.
GeneCardsiMPEG1.
HGNCiHGNC:29619. MPEG1.
HPAiHPA046801.
MIMi610390. gene.
neXtProtiNX_Q2M385.
OpenTargetsiENSG00000197629.
PharmGKBiPA164723088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IER6. Eukaryota.
ENOG410ZMVS. LUCA.
GeneTreeiENSGT00390000008048.
HOGENOMiHOG000024828.
HOVERGENiHBG057416.
InParanoidiQ2M385.
OMAiRPPLMSQ.
OrthoDBiEOG091G027S.
PhylomeDBiQ2M385.
TreeFamiTF331165.

Enzyme and pathway databases

BioCyciZFISH:G66-31458-MONOMER.

Miscellaneous databases

GenomeRNAii219972.
PROiQ2M385.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197629.
GenevisibleiQ2M385. HS.

Family and domain databases

InterProiIPR020864. MACPF.
[Graphical view]
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
PROSITEiPS51412. MACPF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPEG1_HUMAN
AccessioniPrimary (citable) accession number: Q2M385
Secondary accession number(s): Q2M1T6, Q8TEF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 21, 2006
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.