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Protein

Ribonuclease H2 subunit C

Gene

RNASEH2C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit C
Short name:
RNase H2 subunit C
Alternative name(s):
Ribonuclease HI subunit C
Gene namesi
Name:RNASEH2C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Ribonuclease H2 subunit CPRO_0000248384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2M2U4.
PRIDEiQ2M2U4.

Interactioni

Subunit structurei

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007327.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase H2 subunit C family.Curated

Phylogenomic databases

eggNOGiENOG410J0SE. Eukaryota.
ENOG41126TY. LUCA.
GeneTreeiENSGT00390000001568.
HOGENOMiHOG000230780.
HOVERGENiHBG093917.
InParanoidiQ2M2U4.
KOiK10745.
OMAiHLLPCDV.
OrthoDBiEOG779P0Q.
TreeFamiTF324370.

Family and domain databases

InterProiIPR013924. RNase_H2_suC.
[Graphical view]
PfamiPF08615. RNase_H2_suC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2M2U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSYEETID KRRVHLRPDT LRDPAPASLH LLPCEVPVNR PTPVGRFFTP
60 70 80 90 100
AIRMGRDGLE ASFRGRSLRG EEVVVPPGFV GYVVTEEKAE VLMGKQDDHE
110 120 130 140 150
RQEQELLEPP EALERDCDRF MGATASFSSF TVWGLESIPG PDAKLRGALS
160
WPSLAAAIHA QVPED
Length:165
Mass (Da):18,349
Last modified:February 21, 2006 - v1
Checksum:i0F8E0AA3B7284141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111611 mRNA. Translation: AAI11612.1.
RefSeqiNP_001039386.1. NM_001045921.1.
UniGeneiBt.91207.

Genome annotation databases

EnsembliENSBTAT00000007327; ENSBTAP00000007327; ENSBTAG00000005577.
GeneIDi505618.
KEGGibta:505618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111611 mRNA. Translation: AAI11612.1.
RefSeqiNP_001039386.1. NM_001045921.1.
UniGeneiBt.91207.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007327.

Proteomic databases

PaxDbiQ2M2U4.
PRIDEiQ2M2U4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007327; ENSBTAP00000007327; ENSBTAG00000005577.
GeneIDi505618.
KEGGibta:505618.

Organism-specific databases

CTDi84153.

Phylogenomic databases

eggNOGiENOG410J0SE. Eukaryota.
ENOG41126TY. LUCA.
GeneTreeiENSGT00390000001568.
HOGENOMiHOG000230780.
HOVERGENiHBG093917.
InParanoidiQ2M2U4.
KOiK10745.
OMAiHLLPCDV.
OrthoDBiEOG779P0Q.
TreeFamiTF324370.

Miscellaneous databases

NextBioi20867227.

Family and domain databases

InterProiIPR013924. RNase_H2_suC.
[Graphical view]
PfamiPF08615. RNase_H2_suC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiRNH2C_BOVIN
AccessioniPrimary (citable) accession number: Q2M2U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: February 21, 2006
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.