Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal targeting signal 1 receptor

Gene

Pex5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-RNO-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 1 receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
PTS1-BP
Peroxin-5
Peroxisomal C-terminal targeting signal import receptor
Peroxisome receptor 1
Gene namesi
Name:Pex5
Synonyms:Pex5_predicted
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1307612 Pex5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003965031 – 640Peroxisomal targeting signal 1 receptorAdd BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei114PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1
Modified residuei154PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei280PhosphoserineBy similarity1

Post-translational modificationi

Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.By similarity

Keywords - PTMi

Phosphoprotein, Thioester bond, Ubl conjugation

Proteomic databases

PaxDbiQ2M2R8
PRIDEiQ2M2R8

PTM databases

iPTMnetiQ2M2R8
PhosphoSitePlusiQ2M2R8

Expressioni

Gene expression databases

BgeeiENSRNOG00000010407
GenevisibleiQ2M2R8 RN

Interactioni

Subunit structurei

Interacts with PEX7, PEX12, PEX13 and PEX14.By similarity

Protein-protein interaction databases

BioGridi260235, 4 interactors
STRINGi10116.ENSRNOP00000014028

Structurei

3D structure databases

SMRiQ2M2R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati336 – 369TPR 1Add BLAST34
Repeati371 – 403TPR 2Add BLAST33
Repeati404 – 437TPR 3Add BLAST34
Repeati454 – 486TPR 4Add BLAST33
Repeati489 – 522TPR 5Add BLAST34
Repeati524 – 556TPR 6Add BLAST33
Repeati558 – 590TPR 7Add BLAST33

Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1125 Eukaryota
ENOG410XQ6Q LUCA
GeneTreeiENSGT00390000013941
HOGENOMiHOG000158146
HOVERGENiHBG053575
InParanoidiQ2M2R8
KOiK13342
OMAiQAENEMD
PhylomeDBiQ2M2R8
TreeFamiTF315044

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR024113 PTS1R
IPR024111 PTS1R_family
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10130 PTHR10130, 1 hit
PTHR10130:SF2 PTHR10130:SF2, 1 hit
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q2M2R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRELVESE CGGANPLMKL ATHFTQDKAL RQEGLRPPWP PGASAAETVS
60 70 80 90 100
KPLGVGTEDE LVAEFLQDQN ATLVSRAPQT FKMDDLLAEM QEIEQSNFRQ
110 120 130 140 150
APQRAPGVAD LALSENWAQE FLAAGDAVDV AQDYNETDWS QEFIAEVTDP
160 170 180 190 200
LSVSPARWAE EYLEQSEEKL WLGDPEGTST TDRWYDEYHP EEDLQHTASD
210 220 230 240 250
FVSKVDDPKL ANSEFLKFVR QIGEGQVSLE SAAGSGRAQA EQWAAEFIQQ
260 270 280 290 300
QGTSEAWVDQ FTRPGNKLAA LQVEFERAKS AIESDVDFWD KLQAELEEMA
310 320 330 340 350
KRDAEAHPWL SDYDDLTSAS YDKGYQFEEE NPLRDHPQPF EEGLRRLEEG
360 370 380 390 400
DLPNAVLLFE AAVQQDPKHM EAWQYLGTTQ AENEQELLAI SALRRCLELK
410 420 430 440 450
PDNRTALMAL AVSFTNESLQ RQACETLRDW LRYSPAYAHL VAPGEEGASG
460 470 480 490 500
AGLGPSKRVL GSLLSDSLFL EVKELFLAAV RLDPTSIDPD VQCGLGVLFN
510 520 530 540 550
LSGEYDKAVD CFTAALSVRP NDYLLWNKLG ATLANGNQSE EAVAAYRRAL
560 570 580 590 600
ELQPGYIRSR YNLGISCINL GAHREAVEHF LEALNMQRKS RGPRGEGGAM
610 620 630 640
SENIWSTLRL ALSMLGQSDA YGAADARDLP ALLTMFGLPQ
Length:640
Mass (Da):71,022
Last modified:August 10, 2010 - v2
Checksum:i57B65CDA460A5BD6
GO

Sequence cautioni

The sequence EDM01958 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473964 Genomic DNA Translation: EDM01958.1 Sequence problems.
BC111709 mRNA Translation: AAI11710.1
RefSeqiNP_001164055.1, NM_001170584.1
XP_006237446.1, XM_006237384.2
XP_006237447.1, XM_006237385.3
XP_008761499.1, XM_008763277.2
UniGeneiRn.14316

Genome annotation databases

EnsembliENSRNOT00000085675; ENSRNOP00000070292; ENSRNOG00000010407
GeneIDi103690024
312703
KEGGirno:103690024
rno:312703
UCSCiRGD:1307612 rat

Entry informationi

Entry nameiPEX5_RAT
AccessioniPrimary (citable) accession number: Q2M2R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 23, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health