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Q2M2I5 (K1C24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 24
Alternative name(s):
Cytokeratin-24
Short name=CK-24
Keratin-24
Short name=K24
Type I keratin-24
Gene names
Name:KRT24
Synonyms:KA24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins.

Tissue specificity

Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus and testis. Ref.3

Induction

Up-regulated in the mucosa of patients suffering of colorectal cancer. Ref.4

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

intermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

intermediate filament cytoskeleton

Inferred from direct assay. Source: HPA

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 525525Keratin, type I cytoskeletal 24
PRO_0000314850

Regions

Region1 – 139139Head
Region140 – 452313Rod
Region140 – 17536Coil 1A
Region176 – 19823Linker 1
Region199 – 29092Coil 1B
Region291 – 31323Linker 12
Region314 – 452139Coil 2
Region453 – 52573Tail
Compositional bias13 – 138126Gly-rich

Natural variations

Natural variant1151A → T.
Corresponds to variant rs9914185 [ dbSNP | Ensembl ].
VAR_038068
Natural variant2501G → D.
Corresponds to variant rs7211480 [ dbSNP | Ensembl ].
VAR_038069
Natural variant2671M → I.
Corresponds to variant rs874889 [ dbSNP | Ensembl ].
VAR_038070
Natural variant3661R → C.
Corresponds to variant rs16966138 [ dbSNP | Ensembl ].
VAR_038071
Natural variant4151C → Y.
Corresponds to variant rs12945784 [ dbSNP | Ensembl ].
VAR_038072
Natural variant4181W → R.
Corresponds to variant rs12946793 [ dbSNP | Ensembl ].
VAR_038073
Natural variant4291K → E.
Corresponds to variant rs2462961 [ dbSNP | Ensembl ].
VAR_038074

Experimental info

Sequence conflict581G → D in BAA91044. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q2M2I5 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: 1729C08E2277C865

FASTA52555,087
        10         20         30         40         50         60 
MSCSSRASSS RAGGSSSARV SAGGSSFSSG SRCGLGGSSA QGFRGGASSC SLSGGSSGAF 

        70         80         90        100        110        120 
GGSFGGGFGS CSVGGGFGGA SGSGTGFGGG SSFGGVSGFG RGSGFCGSSR FSSGATGGFY 

       130        140        150        160        170        180 
SYGGGMGGGV GDGGLFSGGE KQTMQNLNDR LANYLDKVRA LEEANTDLEN KIKEWYDKYG 

       190        200        210        220        230        240 
PGSGDGGSGR DYSKYYSIIE DLRNQIIAAT VENAGIILHI DNARLAADDF RLKYENELCL 

       250        260        270        280        290        300 
RQSVEADING LRKVLDDLTM TRSDLEMQIE SFTEELAYLR KNHEEEMKNM QGSSGGEVTV 

       310        320        330        340        350        360 
EMNAAPGTDL TKLLNDMRAQ YEELAEQNRR EAEERFNKQS ASLQAQISTD AGAATSAKNE 

       370        380        390        400        410        420 
ITELKRTLQA LEIELQSQLA MKSSLEGTLA DTEAGYVAQL SEIQTQISAL EEEICQIWGE 

       430        440        450        460        470        480 
TKCQNAEYKQ LLDIKTRLEV EIETYRRLLD GEGGGSSFAE FGGRNSGSVN MGSRDLVSGD 

       490        500        510        520 
SRSGSCSGQG RDSSKTRVTK TIVEELVDGK VVSSQVSSIS EVKVK 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon mucosa.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM interval on chromosome 17q11.2-q21 and investigation of candidate genes."
Sprecher E., Itin P., Whittock N.V., McGrath J.A., Meyer R., DiGiovanna J.J., Bale S.J., Uitto J., Richard G.
J. Invest. Dermatol. 119:692-698(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[4]"A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis."
Hong Y., Ho K.S., Eu K.W., Cheah P.Y.
Clin. Cancer Res. 13:1107-1114(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000268 mRNA. Translation: BAA91044.1.
BC111968 mRNA. Translation: AAI11969.1.
CCDSCCDS11372.1.
RefSeqNP_061889.2. NM_019016.2.
UniGeneHs.87383.

3D structure databases

ProteinModelPortalQ2M2I5.
SMRQ2M2I5. Positions 195-292, 309-451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128175. 11 interactions.
IntActQ2M2I5. 5 interactions.
STRING9606.ENSP00000264651.

PTM databases

PhosphoSiteQ2M2I5.

Polymorphism databases

DMDM121941436.

Proteomic databases

MaxQBQ2M2I5.
PaxDbQ2M2I5.
PRIDEQ2M2I5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264651; ENSP00000264651; ENSG00000167916.
GeneID192666.
KEGGhsa:192666.
UCSCuc002hvd.3. human.

Organism-specific databases

CTD192666.
GeneCardsGC17M038854.
H-InvDBHIX0013802.
HGNCHGNC:18527. KRT24.
HPAHPA022978.
MIM607742. gene.
neXtProtNX_Q2M2I5.
PharmGKBPA38344.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146351.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidQ2M2I5.
KOK07604.
OMANMGSRDL.
OrthoDBEOG7FV3Q8.
PhylomeDBQ2M2I5.
TreeFamTF332742.

Gene expression databases

BgeeQ2M2I5.
CleanExHS_KRT24.
GenevestigatorQ2M2I5.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
SUPFAMSSF46579. SSF46579. 1 hit.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi192666.
NextBio89359.
PROQ2M2I5.
SOURCESearch...

Entry information

Entry nameK1C24_HUMAN
AccessionPrimary (citable) accession number: Q2M2I5
Secondary accession number(s): Q9NXG7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 21, 2006
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM