Q2M2I5 (K1C24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cytoskeletal 24

Alternative name(s):
Cytokeratin-24
Short name=CK-24
Keratin-24
Short name=K24
Type I keratin-24

Gene names

Name:	KRT24
Synonyms:	KA24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	525 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins.
Tissue specificity	Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus and testis. Ref.3
Induction	Up-regulated in the mucosa of patients suffering of colorectal cancer. Ref.4
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW intermediate filament cytoskeleton Inferred from direct assay. Source: HPA
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 525	525	Keratin, type I cytoskeletal 24		PRO_0000314850
Regions
	Region	1 – 139	139	Head
	Region	140 – 452	313	Rod
	Region	140 – 175	36	Coil 1A
	Region	176 – 198	23	Linker 1
	Region	199 – 290	92	Coil 1B
	Region	291 – 313	23	Linker 12
	Region	314 – 452	139	Coil 2
	Region	453 – 525	73	Tail
	Compositional bias	13 – 138	126	Gly-rich
Natural variations
	Natural variant	115	1	A → T. Corresponds to variant rs9914185 [ dbSNP | Ensembl ].		VAR_038068
	Natural variant	250	1	G → D. Corresponds to variant rs7211480 [ dbSNP | Ensembl ].		VAR_038069
	Natural variant	267	1	M → I. Corresponds to variant rs874889 [ dbSNP | Ensembl ].		VAR_038070
	Natural variant	366	1	R → C. Corresponds to variant rs16966138 [ dbSNP | Ensembl ].		VAR_038071
	Natural variant	415	1	C → Y. Corresponds to variant rs12945784 [ dbSNP | Ensembl ].		VAR_038072
	Natural variant	418	1	W → R. Corresponds to variant rs12946793 [ dbSNP | Ensembl ].		VAR_038073
	Natural variant	429	1	K → E. Corresponds to variant rs2462961 [ dbSNP | Ensembl ].		VAR_038074
Experimental info
	Sequence conflict	58	1	G → D in BAA91044. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q2M2I5 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: 1729C08E2277C865	FASTA	525	55,087
	10 20 30 40 50 60 MSCSSRASSS RAGGSSSARV SAGGSSFSSG SRCGLGGSSA QGFRGGASSC SLSGGSSGAF 70 80 90 100 110 120 GGSFGGGFGS CSVGGGFGGA SGSGTGFGGG SSFGGVSGFG RGSGFCGSSR FSSGATGGFY 130 140 150 160 170 180 SYGGGMGGGV GDGGLFSGGE KQTMQNLNDR LANYLDKVRA LEEANTDLEN KIKEWYDKYG 190 200 210 220 230 240 PGSGDGGSGR DYSKYYSIIE DLRNQIIAAT VENAGIILHI DNARLAADDF RLKYENELCL 250 260 270 280 290 300 RQSVEADING LRKVLDDLTM TRSDLEMQIE SFTEELAYLR KNHEEEMKNM QGSSGGEVTV 310 320 330 340 350 360 EMNAAPGTDL TKLLNDMRAQ YEELAEQNRR EAEERFNKQS ASLQAQISTD AGAATSAKNE 370 380 390 400 410 420 ITELKRTLQA LEIELQSQLA MKSSLEGTLA DTEAGYVAQL SEIQTQISAL EEEICQIWGE 430 440 450 460 470 480 TKCQNAEYKQ LLDIKTRLEV EIETYRRLLD GEGGGSSFAE FGGRNSGSVN MGSRDLVSGD 490 500 510 520 SRSGSCSGQG RDSSKTRVTK TIVEELVDGK VVSSQVSSIS EVKVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon mucosa.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM interval on chromosome 17q11.2-q21 and investigation of candidate genes." Sprecher E., Itin P., Whittock N.V., McGrath J.A., Meyer R., DiGiovanna J.J., Bale S.J., Uitto J., Richard G. J. Invest. Dermatol. 119:692-698(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[4]	"A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis." Hong Y., Ho K.S., Eu K.W., Cheah P.Y. Clin. Cancer Res. 13:1107-1114(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000268 mRNA. Translation: BAA91044.1. BC111968 mRNA. Translation: AAI11969.1.
IPI	IPI00004550.
RefSeq	NP_061889.2. NM_019016.2.
UniGene	Hs.87383.
3D structure databases
ProteinModelPortal	Q2M2I5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q2M2I5. 5 interactions.
STRING	9606.ENSP00000264651.
PTM databases
PhosphoSite	Q2M2I5.
Polymorphism databases
DMDM	121941436.
Proteomic databases
PaxDb	Q2M2I5.
PRIDE	Q2M2I5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264651; ENSP00000264651; ENSG00000167916.
GeneID	192666.
KEGG	hsa:192666.
UCSC	uc002hvd.3. human.
Organism-specific databases
CTD	192666.
GeneCards	GC17M038854.
H-InvDB	HIX0013802.
HGNC	HGNC:18527. KRT24.
HPA	HPA022978.
MIM	607742. gene.
neXtProt	NX_Q2M2I5.
PharmGKB	PA38344.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146351.
HOGENOM	HOG000230975.
HOVERGEN	HBG013015.
InParanoid	Q2M2I5.
KO	K07604.
OMA	YSKYYSI.
OrthoDB	EOG4P8FJH.
PhylomeDB	Q2M2I5.
Gene expression databases
Bgee	Q2M2I5.
CleanEx	HS_KRT24.
Genevestigator	Q2M2I5.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. IPR009053. Prefoldin. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
SUPFAM	SSF46579. Prefoldin. 1 hit.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	192666.
NextBio	89359.
SOURCE	Search...

Entry information

Entry name

K1C24_HUMAN

Accession

Primary (citable) accession number: Q2M2I5
Secondary accession number(s): Q9NXG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 21, 2006
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.