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Q2M2I5

- K1C24_HUMAN

UniProt

Q2M2I5 - K1C24_HUMAN

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Protein

Keratin, type I cytoskeletal 24

Gene

KRT24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 24
Alternative name(s):
Cytokeratin-24
Short name:
CK-24
Keratin-24
Short name:
K24
Type I keratin-24
Gene namesi
Name:KRT24
Synonyms:KA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18527. KRT24.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. extracellular vesicular exosome Source: UniProtKB
  3. intermediate filament Source: UniProtKB-KW
  4. intermediate filament cytoskeleton Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Keratin, type I cytoskeletal 24PRO_0000314850Add
BLAST

Proteomic databases

MaxQBiQ2M2I5.
PaxDbiQ2M2I5.
PRIDEiQ2M2I5.

PTM databases

PhosphoSiteiQ2M2I5.

Expressioni

Tissue specificityi

Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus and testis.1 Publication

Inductioni

Up-regulated in the mucosa of patients suffering of colorectal cancer.1 Publication

Gene expression databases

BgeeiQ2M2I5.
CleanExiHS_KRT24.
GenevestigatoriQ2M2I5.

Organism-specific databases

HPAiHPA022978.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi128175. 11 interactions.
IntActiQ2M2I5. 5 interactions.
STRINGi9606.ENSP00000264651.

Structurei

3D structure databases

ProteinModelPortaliQ2M2I5.
SMRiQ2M2I5. Positions 195-292, 309-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 139139HeadAdd
BLAST
Regioni140 – 452313RodAdd
BLAST
Regioni140 – 17536Coil 1AAdd
BLAST
Regioni176 – 19823Linker 1Add
BLAST
Regioni199 – 29092Coil 1BAdd
BLAST
Regioni291 – 31323Linker 12Add
BLAST
Regioni314 – 452139Coil 2Add
BLAST
Regioni453 – 52573TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 138126Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG146351.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ2M2I5.
KOiK07604.
OMAiNMGSRDL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ2M2I5.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2M2I5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCSSRASSS RAGGSSSARV SAGGSSFSSG SRCGLGGSSA QGFRGGASSC
60 70 80 90 100
SLSGGSSGAF GGSFGGGFGS CSVGGGFGGA SGSGTGFGGG SSFGGVSGFG
110 120 130 140 150
RGSGFCGSSR FSSGATGGFY SYGGGMGGGV GDGGLFSGGE KQTMQNLNDR
160 170 180 190 200
LANYLDKVRA LEEANTDLEN KIKEWYDKYG PGSGDGGSGR DYSKYYSIIE
210 220 230 240 250
DLRNQIIAAT VENAGIILHI DNARLAADDF RLKYENELCL RQSVEADING
260 270 280 290 300
LRKVLDDLTM TRSDLEMQIE SFTEELAYLR KNHEEEMKNM QGSSGGEVTV
310 320 330 340 350
EMNAAPGTDL TKLLNDMRAQ YEELAEQNRR EAEERFNKQS ASLQAQISTD
360 370 380 390 400
AGAATSAKNE ITELKRTLQA LEIELQSQLA MKSSLEGTLA DTEAGYVAQL
410 420 430 440 450
SEIQTQISAL EEEICQIWGE TKCQNAEYKQ LLDIKTRLEV EIETYRRLLD
460 470 480 490 500
GEGGGSSFAE FGGRNSGSVN MGSRDLVSGD SRSGSCSGQG RDSSKTRVTK
510 520
TIVEELVDGK VVSSQVSSIS EVKVK
Length:525
Mass (Da):55,087
Last modified:February 21, 2006 - v1
Checksum:i1729C08E2277C865
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581G → D in BAA91044. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151A → T.
Corresponds to variant rs9914185 [ dbSNP | Ensembl ].
VAR_038068
Natural varianti250 – 2501G → D.
Corresponds to variant rs7211480 [ dbSNP | Ensembl ].
VAR_038069
Natural varianti267 – 2671M → I.
Corresponds to variant rs874889 [ dbSNP | Ensembl ].
VAR_038070
Natural varianti366 – 3661R → C.
Corresponds to variant rs16966138 [ dbSNP | Ensembl ].
VAR_038071
Natural varianti415 – 4151C → Y.
Corresponds to variant rs12945784 [ dbSNP | Ensembl ].
VAR_038072
Natural varianti418 – 4181W → R.
Corresponds to variant rs12946793 [ dbSNP | Ensembl ].
VAR_038073
Natural varianti429 – 4291K → E.
Corresponds to variant rs2462961 [ dbSNP | Ensembl ].
VAR_038074

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000268 mRNA. Translation: BAA91044.1.
BC111968 mRNA. Translation: AAI11969.1.
CCDSiCCDS11372.1.
RefSeqiNP_061889.2. NM_019016.2.
UniGeneiHs.87383.

Genome annotation databases

EnsembliENST00000264651; ENSP00000264651; ENSG00000167916.
GeneIDi192666.
KEGGihsa:192666.
UCSCiuc002hvd.3. human.

Polymorphism databases

DMDMi121941436.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000268 mRNA. Translation: BAA91044.1 .
BC111968 mRNA. Translation: AAI11969.1 .
CCDSi CCDS11372.1.
RefSeqi NP_061889.2. NM_019016.2.
UniGenei Hs.87383.

3D structure databases

ProteinModelPortali Q2M2I5.
SMRi Q2M2I5. Positions 195-292, 309-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128175. 11 interactions.
IntActi Q2M2I5. 5 interactions.
STRINGi 9606.ENSP00000264651.

PTM databases

PhosphoSitei Q2M2I5.

Polymorphism databases

DMDMi 121941436.

Proteomic databases

MaxQBi Q2M2I5.
PaxDbi Q2M2I5.
PRIDEi Q2M2I5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264651 ; ENSP00000264651 ; ENSG00000167916 .
GeneIDi 192666.
KEGGi hsa:192666.
UCSCi uc002hvd.3. human.

Organism-specific databases

CTDi 192666.
GeneCardsi GC17M038854.
H-InvDB HIX0013802.
HGNCi HGNC:18527. KRT24.
HPAi HPA022978.
MIMi 607742. gene.
neXtProti NX_Q2M2I5.
PharmGKBi PA38344.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146351.
GeneTreei ENSGT00760000118808.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi Q2M2I5.
KOi K07604.
OMAi NMGSRDL.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q2M2I5.
TreeFami TF332742.

Miscellaneous databases

GenomeRNAii 192666.
NextBioi 89359.
PROi Q2M2I5.
SOURCEi Search...

Gene expression databases

Bgeei Q2M2I5.
CleanExi HS_KRT24.
Genevestigatori Q2M2I5.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
SUPFAMi SSF46579. SSF46579. 1 hit.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon mucosa.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM interval on chromosome 17q11.2-q21 and investigation of candidate genes."
    Sprecher E., Itin P., Whittock N.V., McGrath J.A., Meyer R., DiGiovanna J.J., Bale S.J., Uitto J., Richard G.
    J. Invest. Dermatol. 119:692-698(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis."
    Hong Y., Ho K.S., Eu K.W., Cheah P.Y.
    Clin. Cancer Res. 13:1107-1114(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiK1C24_HUMAN
AccessioniPrimary (citable) accession number: Q2M2I5
Secondary accession number(s): Q9NXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3