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Protein

Keratin, type I cytoskeletal 24

Gene

KRT24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 24
Alternative name(s):
Cytokeratin-24
Short name:
CK-24
Keratin-24
Short name:
K24
Type I keratin-24
Gene namesi
Name:KRT24
Synonyms:KA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18527. KRT24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167916.
PharmGKBiPA38344.

Polymorphism and mutation databases

BioMutaiKRT24.
DMDMi121941436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148501 – 525Keratin, type I cytoskeletal 24Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei487PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2M2I5.
PeptideAtlasiQ2M2I5.
PRIDEiQ2M2I5.

PTM databases

iPTMnetiQ2M2I5.
PhosphoSitePlusiQ2M2I5.

Expressioni

Tissue specificityi

Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus and testis.1 Publication

Inductioni

Up-regulated in the mucosa of patients suffering of colorectal cancer.1 Publication

Gene expression databases

BgeeiENSG00000167916.
CleanExiHS_KRT24.
GenevisibleiQ2M2I5. HS.

Organism-specific databases

HPAiHPA022978.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi128175. 11 interactors.
IntActiQ2M2I5. 14 interactors.
STRINGi9606.ENSP00000264651.

Structurei

3D structure databases

ProteinModelPortaliQ2M2I5.
SMRiQ2M2I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 139HeadAdd BLAST139
Regioni140 – 452RodAdd BLAST313
Regioni140 – 175Coil 1AAdd BLAST36
Regioni176 – 198Linker 1Add BLAST23
Regioni199 – 290Coil 1BAdd BLAST92
Regioni291 – 313Linker 12Add BLAST23
Regioni314 – 452Coil 2Add BLAST139
Regioni453 – 525TailAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 138Gly-richAdd BLAST126

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ2M2I5.
KOiK07604.
OMAiEMQIESF.
OrthoDBiEOG091G087I.
PhylomeDBiQ2M2I5.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2M2I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCSSRASSS RAGGSSSARV SAGGSSFSSG SRCGLGGSSA QGFRGGASSC
60 70 80 90 100
SLSGGSSGAF GGSFGGGFGS CSVGGGFGGA SGSGTGFGGG SSFGGVSGFG
110 120 130 140 150
RGSGFCGSSR FSSGATGGFY SYGGGMGGGV GDGGLFSGGE KQTMQNLNDR
160 170 180 190 200
LANYLDKVRA LEEANTDLEN KIKEWYDKYG PGSGDGGSGR DYSKYYSIIE
210 220 230 240 250
DLRNQIIAAT VENAGIILHI DNARLAADDF RLKYENELCL RQSVEADING
260 270 280 290 300
LRKVLDDLTM TRSDLEMQIE SFTEELAYLR KNHEEEMKNM QGSSGGEVTV
310 320 330 340 350
EMNAAPGTDL TKLLNDMRAQ YEELAEQNRR EAEERFNKQS ASLQAQISTD
360 370 380 390 400
AGAATSAKNE ITELKRTLQA LEIELQSQLA MKSSLEGTLA DTEAGYVAQL
410 420 430 440 450
SEIQTQISAL EEEICQIWGE TKCQNAEYKQ LLDIKTRLEV EIETYRRLLD
460 470 480 490 500
GEGGGSSFAE FGGRNSGSVN MGSRDLVSGD SRSGSCSGQG RDSSKTRVTK
510 520
TIVEELVDGK VVSSQVSSIS EVKVK
Length:525
Mass (Da):55,087
Last modified:February 21, 2006 - v1
Checksum:i1729C08E2277C865
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58G → D in BAA91044 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038068115A → T.Corresponds to variant rs9914185dbSNPEnsembl.1
Natural variantiVAR_038069250G → D.Corresponds to variant rs7211480dbSNPEnsembl.1
Natural variantiVAR_038070267M → I.Corresponds to variant rs874889dbSNPEnsembl.1
Natural variantiVAR_038071366R → C.Corresponds to variant rs16966138dbSNPEnsembl.1
Natural variantiVAR_038072415C → Y.Corresponds to variant rs12945784dbSNPEnsembl.1
Natural variantiVAR_038073418W → R.Corresponds to variant rs12946793dbSNPEnsembl.1
Natural variantiVAR_038074429K → E.Corresponds to variant rs2462961dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000268 mRNA. Translation: BAA91044.1.
BC111968 mRNA. Translation: AAI11969.1.
CCDSiCCDS11372.1.
RefSeqiNP_061889.2. NM_019016.2.
UniGeneiHs.87383.

Genome annotation databases

EnsembliENST00000264651; ENSP00000264651; ENSG00000167916.
GeneIDi192666.
KEGGihsa:192666.
UCSCiuc002hvd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000268 mRNA. Translation: BAA91044.1.
BC111968 mRNA. Translation: AAI11969.1.
CCDSiCCDS11372.1.
RefSeqiNP_061889.2. NM_019016.2.
UniGeneiHs.87383.

3D structure databases

ProteinModelPortaliQ2M2I5.
SMRiQ2M2I5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128175. 11 interactors.
IntActiQ2M2I5. 14 interactors.
STRINGi9606.ENSP00000264651.

PTM databases

iPTMnetiQ2M2I5.
PhosphoSitePlusiQ2M2I5.

Polymorphism and mutation databases

BioMutaiKRT24.
DMDMi121941436.

Proteomic databases

PaxDbiQ2M2I5.
PeptideAtlasiQ2M2I5.
PRIDEiQ2M2I5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264651; ENSP00000264651; ENSG00000167916.
GeneIDi192666.
KEGGihsa:192666.
UCSCiuc002hvd.3. human.

Organism-specific databases

CTDi192666.
GeneCardsiKRT24.
H-InvDBHIX0013802.
HGNCiHGNC:18527. KRT24.
HPAiHPA022978.
MIMi607742. gene.
neXtProtiNX_Q2M2I5.
OpenTargetsiENSG00000167916.
PharmGKBiPA38344.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ2M2I5.
KOiK07604.
OMAiEMQIESF.
OrthoDBiEOG091G087I.
PhylomeDBiQ2M2I5.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii192666.
PROiQ2M2I5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167916.
CleanExiHS_KRT24.
GenevisibleiQ2M2I5. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C24_HUMAN
AccessioniPrimary (citable) accession number: Q2M2I5
Secondary accession number(s): Q9NXG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 21, 2006
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.