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Q2M2I5

- K1C24_HUMAN

UniProt

Q2M2I5 - K1C24_HUMAN

Protein

Keratin, type I cytoskeletal 24

Gene

KRT24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cytoskeletal 24
    Alternative name(s):
    Cytokeratin-24
    Short name:
    CK-24
    Keratin-24
    Short name:
    K24
    Type I keratin-24
    Gene namesi
    Name:KRT24
    Synonyms:KA24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18527. KRT24.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. intermediate filament Source: UniProtKB-KW
    3. intermediate filament cytoskeleton Source: HPA

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38344.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Keratin, type I cytoskeletal 24PRO_0000314850Add
    BLAST

    Proteomic databases

    MaxQBiQ2M2I5.
    PaxDbiQ2M2I5.
    PRIDEiQ2M2I5.

    PTM databases

    PhosphoSiteiQ2M2I5.

    Expressioni

    Tissue specificityi

    Highly expressed in keratinocytes, placenta, colon and spleen. Expressed at lower level in thymus and testis.1 Publication

    Inductioni

    Up-regulated in the mucosa of patients suffering of colorectal cancer.1 Publication

    Gene expression databases

    BgeeiQ2M2I5.
    CleanExiHS_KRT24.
    GenevestigatoriQ2M2I5.

    Organism-specific databases

    HPAiHPA022978.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.

    Protein-protein interaction databases

    BioGridi128175. 11 interactions.
    IntActiQ2M2I5. 5 interactions.
    STRINGi9606.ENSP00000264651.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2M2I5.
    SMRiQ2M2I5. Positions 195-292, 309-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 139139HeadAdd
    BLAST
    Regioni140 – 452313RodAdd
    BLAST
    Regioni140 – 17536Coil 1AAdd
    BLAST
    Regioni176 – 19823Linker 1Add
    BLAST
    Regioni199 – 29092Coil 1BAdd
    BLAST
    Regioni291 – 31323Linker 12Add
    BLAST
    Regioni314 – 452139Coil 2Add
    BLAST
    Regioni453 – 52573TailAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi13 – 138126Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG146351.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ2M2I5.
    KOiK07604.
    OMAiNMGSRDL.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ2M2I5.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    SUPFAMiSSF46579. SSF46579. 1 hit.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2M2I5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSCSSRASSS RAGGSSSARV SAGGSSFSSG SRCGLGGSSA QGFRGGASSC    50
    SLSGGSSGAF GGSFGGGFGS CSVGGGFGGA SGSGTGFGGG SSFGGVSGFG 100
    RGSGFCGSSR FSSGATGGFY SYGGGMGGGV GDGGLFSGGE KQTMQNLNDR 150
    LANYLDKVRA LEEANTDLEN KIKEWYDKYG PGSGDGGSGR DYSKYYSIIE 200
    DLRNQIIAAT VENAGIILHI DNARLAADDF RLKYENELCL RQSVEADING 250
    LRKVLDDLTM TRSDLEMQIE SFTEELAYLR KNHEEEMKNM QGSSGGEVTV 300
    EMNAAPGTDL TKLLNDMRAQ YEELAEQNRR EAEERFNKQS ASLQAQISTD 350
    AGAATSAKNE ITELKRTLQA LEIELQSQLA MKSSLEGTLA DTEAGYVAQL 400
    SEIQTQISAL EEEICQIWGE TKCQNAEYKQ LLDIKTRLEV EIETYRRLLD 450
    GEGGGSSFAE FGGRNSGSVN MGSRDLVSGD SRSGSCSGQG RDSSKTRVTK 500
    TIVEELVDGK VVSSQVSSIS EVKVK 525
    Length:525
    Mass (Da):55,087
    Last modified:February 21, 2006 - v1
    Checksum:i1729C08E2277C865
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581G → D in BAA91044. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151A → T.
    Corresponds to variant rs9914185 [ dbSNP | Ensembl ].
    VAR_038068
    Natural varianti250 – 2501G → D.
    Corresponds to variant rs7211480 [ dbSNP | Ensembl ].
    VAR_038069
    Natural varianti267 – 2671M → I.
    Corresponds to variant rs874889 [ dbSNP | Ensembl ].
    VAR_038070
    Natural varianti366 – 3661R → C.
    Corresponds to variant rs16966138 [ dbSNP | Ensembl ].
    VAR_038071
    Natural varianti415 – 4151C → Y.
    Corresponds to variant rs12945784 [ dbSNP | Ensembl ].
    VAR_038072
    Natural varianti418 – 4181W → R.
    Corresponds to variant rs12946793 [ dbSNP | Ensembl ].
    VAR_038073
    Natural varianti429 – 4291K → E.
    Corresponds to variant rs2462961 [ dbSNP | Ensembl ].
    VAR_038074

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000268 mRNA. Translation: BAA91044.1.
    BC111968 mRNA. Translation: AAI11969.1.
    CCDSiCCDS11372.1.
    RefSeqiNP_061889.2. NM_019016.2.
    UniGeneiHs.87383.

    Genome annotation databases

    EnsembliENST00000264651; ENSP00000264651; ENSG00000167916.
    GeneIDi192666.
    KEGGihsa:192666.
    UCSCiuc002hvd.3. human.

    Polymorphism databases

    DMDMi121941436.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000268 mRNA. Translation: BAA91044.1 .
    BC111968 mRNA. Translation: AAI11969.1 .
    CCDSi CCDS11372.1.
    RefSeqi NP_061889.2. NM_019016.2.
    UniGenei Hs.87383.

    3D structure databases

    ProteinModelPortali Q2M2I5.
    SMRi Q2M2I5. Positions 195-292, 309-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128175. 11 interactions.
    IntActi Q2M2I5. 5 interactions.
    STRINGi 9606.ENSP00000264651.

    PTM databases

    PhosphoSitei Q2M2I5.

    Polymorphism databases

    DMDMi 121941436.

    Proteomic databases

    MaxQBi Q2M2I5.
    PaxDbi Q2M2I5.
    PRIDEi Q2M2I5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264651 ; ENSP00000264651 ; ENSG00000167916 .
    GeneIDi 192666.
    KEGGi hsa:192666.
    UCSCi uc002hvd.3. human.

    Organism-specific databases

    CTDi 192666.
    GeneCardsi GC17M038854.
    H-InvDB HIX0013802.
    HGNCi HGNC:18527. KRT24.
    HPAi HPA022978.
    MIMi 607742. gene.
    neXtProti NX_Q2M2I5.
    PharmGKBi PA38344.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146351.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q2M2I5.
    KOi K07604.
    OMAi NMGSRDL.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q2M2I5.
    TreeFami TF332742.

    Miscellaneous databases

    GenomeRNAii 192666.
    NextBioi 89359.
    PROi Q2M2I5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2M2I5.
    CleanExi HS_KRT24.
    Genevestigatori Q2M2I5.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    SUPFAMi SSF46579. SSF46579. 1 hit.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon mucosa.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM interval on chromosome 17q11.2-q21 and investigation of candidate genes."
      Sprecher E., Itin P., Whittock N.V., McGrath J.A., Meyer R., DiGiovanna J.J., Bale S.J., Uitto J., Richard G.
      J. Invest. Dermatol. 119:692-698(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis."
      Hong Y., Ho K.S., Eu K.W., Cheah P.Y.
      Clin. Cancer Res. 13:1107-1114(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiK1C24_HUMAN
    AccessioniPrimary (citable) accession number: Q2M2I5
    Secondary accession number(s): Q9NXG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3