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Protein

Protein FAM83E

Gene

FAM83E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in MAPK signaling.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM83ECurated
Gene namesi
Name:FAM83EImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105523.3.
HGNCiHGNC:25972. FAM83E.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105523.
PharmGKBiPA142671852.

Polymorphism and mutation databases

BioMutaiFAM83E.
DMDMi311033380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003149291 – 478Protein FAM83EAdd BLAST478

Proteomic databases

PaxDbiQ2M2I3.
PeptideAtlasiQ2M2I3.
PRIDEiQ2M2I3.

PTM databases

iPTMnetiQ2M2I3.
PhosphoSitePlusiQ2M2I3.

Expressioni

Gene expression databases

BgeeiENSG00000105523.
CleanExiHS_FAM83E.
ExpressionAtlasiQ2M2I3. baseline and differential.
GenevisibleiQ2M2I3. HS.

Organism-specific databases

HPAiHPA049305.

Interactioni

Subunit structurei

May interact with RAF1.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliQ2M2I3.
SMRiQ2M2I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM83 family.Curated

Phylogenomic databases

eggNOGiENOG410IJDM. Eukaryota.
ENOG4110FKM. LUCA.
GeneTreeiENSGT00760000119168.
HOGENOMiHOG000015330.
HOVERGENiHBG107906.
InParanoidiQ2M2I3.
OMAiGHPPLKE.
OrthoDBiEOG091G05DE.
PhylomeDBiQ2M2I3.
TreeFamiTF330777.

Family and domain databases

InterProiView protein in InterPro
IPR012461. FAM83.
PANTHERiPTHR16181. PTHR16181. 1 hit.
PfamiView protein in Pfam
PF07894. DUF1669. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2M2I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASQLAALE GVDSGPRVPG ASPGFLYSEG QRLALEALLS KGAEAFQTCV
60 70 80 90 100
QREELWPFLS ADEVQGLAAA AEDWTVAKQE PSGMAEGATT TDVDAGSLSY
110 120 130 140 150
WPGQSEQPAP VLRLGWPVDS AWKGITRAQL YTQPPGEGQP PLKELVRLEI
160 170 180 190 200
QAAHKLVAVV MDVFTDPDLL LDLVDAATRR WVPVYLLLDR QQLPAFLELA
210 220 230 240 250
QQLGVNPWNT ENVDVRVVRG CSFQSRWRRQ VSGTVREKFV LLDGERVISG
260 270 280 290 300
SYSFTWSDAR LHRGLVTLLT GEIVDAFSLE FRTLYAASCP LPPAPPQKPS
310 320 330 340 350
VIGGLQRGRS PHRVSRRRSV APASPPPPDG PLAHRLAACR VSPATPGPAL
360 370 380 390 400
SDILRSVQRA RTPSGPPARP SRSMWDLSRL SQLSGSSDGD NELKKSWGSK
410 420 430 440 450
DTPAKALMRQ RGTGGGPWGE VDSRPPWGGA LPLPPAHRLR YLSPARRRFG
460 470
GDATFKLQEP RGVRPSDWAP RAGLGGQP
Length:478
Mass (Da):51,780
Last modified:November 2, 2010 - v2
Checksum:iC5C2264196DED361
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5Q → R in BAA91009 (PubMed:14702039).Curated1
Sequence conflicti425P → S in BAA91009 (PubMed:14702039).Curated1
Sequence conflicti463V → I in BAA91009 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03813091T → A2 PublicationsCorresponds to variant dbSNP:rs447802Ensembl.1
Natural variantiVAR_038131311P → L1 PublicationCorresponds to variant dbSNP:rs3745728Ensembl.1
Natural variantiVAR_038132372R → H. Corresponds to variant dbSNP:rs3745727Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000207 mRNA. Translation: BAA91009.1.
AC008403 Genomic DNA. No translation available.
AC022154 Genomic DNA. No translation available.
BC111970 mRNA. Translation: AAI11971.1.
BC111972 mRNA. Translation: AAI11973.1.
CCDSiCCDS42587.1.
RefSeqiNP_060178.2. NM_017708.3.
XP_005259076.1. XM_005259019.1.
UniGeneiHs.165803.

Genome annotation databases

EnsembliENST00000263266; ENSP00000263266; ENSG00000105523.
GeneIDi54854.
KEGGihsa:54854.
UCSCiuc002pjn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFA83E_HUMAN
AccessioniPrimary (citable) accession number: Q2M2I3
Secondary accession number(s): Q9NXK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 2, 2010
Last modified: September 27, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families