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Protein

Outer dense fiber protein 4

Gene

ODF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 4
Alternative name(s):
Outer dense fiber of sperm tails protein 4
Testis-specific protein oppo 1
Short name:
hOPPO1
Gene namesi
Name:ODF4
Synonyms:OPPO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19056. ODF4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978853.

Polymorphism and mutation databases

BioMutaiODF4.
DMDMi158564291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Outer dense fiber protein 4PRO_0000304722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2M2E3.
PRIDEiQ2M2E3.

PTM databases

iPTMnetiQ2M2E3.
PhosphoSiteiQ2M2E3.

Expressioni

Tissue specificityi

Expressed in testis and sperm; especially localized to sperm tail (at protein level).1 Publication

Gene expression databases

BgeeiQ2M2E3.
CleanExiHS_ODF4.
ExpressionAtlasiQ2M2E3. baseline and differential.
GenevisibleiQ2M2E3. HS.

Interactioni

Protein-protein interaction databases

BioGridi127017. 5 interactions.
STRINGi9606.ENSP00000331086.

Structurei

3D structure databases

ProteinModelPortaliQ2M2E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZV4. Eukaryota.
ENOG4111BHV. LUCA.
GeneTreeiENSGT00390000003542.
HOGENOMiHOG000115258.
InParanoidiQ2M2E3.
OMAiWSLILSH.
OrthoDBiEOG7M0NS9.
PhylomeDBiQ2M2E3.
TreeFamiTF338228.

Sequencei

Sequence statusi: Complete.

Q2M2E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAEYSGNEF PRSEGERDQH QRPGKERKSG EAGWGTGELG QDGRLLSSTL
60 70 80 90 100
SLSSNRSLGQ RQNSPLPFQW RITHSFRWMA QVLASELSLV AFILLLVVAF
110 120 130 140 150
SKKWLDLSRS LFYQRWPVDV SNRIHTSAHV MSMGLLHFYK SRSCSDLENG
160 170 180 190 200
KVTFIFSTLM LFPINIWIFE LERNVSIPIG WSYFIGWLVL ILYFTCAILC
210 220 230 240 250
YFNHKSFWSL ILSHPSGAVS CSSSFGSVEE SPRAQTITDT PITQEGVLDP

EQKDTHV
Length:257
Mass (Da):29,233
Last modified:September 11, 2007 - v2
Checksum:iB0E743E89798BA39
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341W → R.1 Publication
Corresponds to variant rs12943505 [ dbSNP | Ensembl ].
VAR_035060
Natural varianti98 – 981V → M.3 Publications
Corresponds to variant rs12601097 [ dbSNP | Ensembl ].
VAR_035061
Natural varianti139 – 1391Y → C.3 Publications
Corresponds to variant rs12936935 [ dbSNP | Ensembl ].
VAR_035062

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081120 mRNA. Translation: BAC15594.1.
AY237799 mRNA. Translation: AAO89569.1.
BC112010 mRNA. Translation: AAI12011.1.
BC112014 mRNA. Translation: AAI12015.1.
CCDSiCCDS11140.1.
RefSeqiNP_694552.2. NM_153007.4.
UniGeneiHs.186045.

Genome annotation databases

EnsembliENST00000328248; ENSP00000331086; ENSG00000184650.
GeneIDi146852.
KEGGihsa:146852.
UCSCiuc002gle.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081120 mRNA. Translation: BAC15594.1.
AY237799 mRNA. Translation: AAO89569.1.
BC112010 mRNA. Translation: AAI12011.1.
BC112014 mRNA. Translation: AAI12015.1.
CCDSiCCDS11140.1.
RefSeqiNP_694552.2. NM_153007.4.
UniGeneiHs.186045.

3D structure databases

ProteinModelPortaliQ2M2E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127017. 5 interactions.
STRINGi9606.ENSP00000331086.

PTM databases

iPTMnetiQ2M2E3.
PhosphoSiteiQ2M2E3.

Polymorphism and mutation databases

BioMutaiODF4.
DMDMi158564291.

Proteomic databases

PaxDbiQ2M2E3.
PRIDEiQ2M2E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328248; ENSP00000331086; ENSG00000184650.
GeneIDi146852.
KEGGihsa:146852.
UCSCiuc002gle.2. human.

Organism-specific databases

CTDi146852.
GeneCardsiODF4.
H-InvDBHIX0202523.
HGNCiHGNC:19056. ODF4.
MIMi610097. gene.
neXtProtiNX_Q2M2E3.
PharmGKBiPA134978853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZV4. Eukaryota.
ENOG4111BHV. LUCA.
GeneTreeiENSGT00390000003542.
HOGENOMiHOG000115258.
InParanoidiQ2M2E3.
OMAiWSLILSH.
OrthoDBiEOG7M0NS9.
PhylomeDBiQ2M2E3.
TreeFamiTF338228.

Miscellaneous databases

GenomeRNAii146852.
PROiQ2M2E3.
SOURCEiSearch...

Gene expression databases

BgeeiQ2M2E3.
CleanExiHS_ODF4.
ExpressionAtlasiQ2M2E3. baseline and differential.
GenevisibleiQ2M2E3. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein."
    Kitamura K., Miyagawa Y., Iguchi N., Nishimura H., Tanaka H., Nishimune Y.
    Mol. Hum. Reprod. 9:237-243(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS MET-98 AND CYS-139.
  2. Miyamoto T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-98 AND CYS-139.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-34; MET-98 AND CYS-139.

Entry informationi

Entry nameiODFP4_HUMAN
AccessioniPrimary (citable) accession number: Q2M2E3
Secondary accession number(s): Q8J021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 8, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.