Q2M2E3 (ODFP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer dense fiber protein 4

Alternative name(s):
Outer dense fiber of sperm tails protein 4
Testis-specific protein oppo 1
Short name=hOPPO1

Gene names

Name:	ODF4
Synonyms:	OPPO1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in testis and sperm; especially localized to sperm tail (at protein level). Ref.1

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Outer dense fiber protein 4		PRO_0000304722
Regions
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
Natural variations
	Natural variant	34	1	W → R. Ref.3 Corresponds to variant rs12943505 [ dbSNP | Ensembl ].		VAR_035060
	Natural variant	98	1	V → M. Ref.1 Ref.2 Ref.3 Corresponds to variant rs12601097 [ dbSNP | Ensembl ].		VAR_035061
	Natural variant	139	1	Y → C. Ref.1 Ref.2 Ref.3 Corresponds to variant rs12936935 [ dbSNP | Ensembl ].		VAR_035062

Sequences

	Sequence		Length	Mass (Da)
	Q2M2E3 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: B0E743E89798BA39	FASTA	257	29,233
	10 20 30 40 50 60 MDAEYSGNEF PRSEGERDQH QRPGKERKSG EAGWGTGELG QDGRLLSSTL SLSSNRSLGQ 70 80 90 100 110 120 RQNSPLPFQW RITHSFRWMA QVLASELSLV AFILLLVVAF SKKWLDLSRS LFYQRWPVDV 130 140 150 160 170 180 SNRIHTSAHV MSMGLLHFYK SRSCSDLENG KVTFIFSTLM LFPINIWIFE LERNVSIPIG 190 200 210 220 230 240 WSYFIGWLVL ILYFTCAILC YFNHKSFWSL ILSHPSGAVS CSSSFGSVEE SPRAQTITDT 250 PITQEGVLDP EQKDTHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein." Kitamura K., Miyagawa Y., Iguchi N., Nishimura H., Tanaka H., Nishimune Y. Mol. Hum. Reprod. 9:237-243(2003) [PubMed: 12728016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS MET-98 AND CYS-139.
[2]	Miyamoto T. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-98 AND CYS-139.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-34; MET-98 AND CYS-139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB081120 mRNA. Translation: BAC15594.1. AY237799 mRNA. Translation: AAO89569.1. BC112010 mRNA. Translation: AAI12011.1. BC112014 mRNA. Translation: AAI12015.1.
IPI	IPI00216331.
RefSeq	NP_694552.2. NM_153007.4.
UniGene	Hs.186045.
3D structure databases
ProteinModelPortal	Q2M2E3.
ModBase	Search...
PTM databases
PhosphoSite	Q2M2E3.
Polymorphism databases
DMDM	158564291.
Proteomic databases
PRIDE	Q2M2E3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328248; ENSP00000331086; ENSG00000184650.
GeneID	146852.
KEGG	hsa:146852.
NMPDR	fig|9606.3.peg.13103.
UCSC	uc002gle.1. human.
Organism-specific databases
CTD	146852.
GeneCards	GC17P008243.
H-InvDB	HIX0202523.
HGNC	HGNC:19056. ODF4.
MIM	610097. gene.
neXtProt	NX_Q2M2E3.
PharmGKB	PA134978853.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16427.
GeneTree	ENSGT00390000003542.
HOGENOM	HBG125138.
InParanoid	Q2M2E3.
OMA	LPFQWRI.
OrthoDB	EOG4SQWXK.
PhylomeDB	Q2M2E3.
Gene expression databases
ArrayExpress	Q2M2E3.
Bgee	Q2M2E3.
CleanEx	HS_ODF4.
Genevestigator	Q2M2E3.
Family and domain databases
ProtoNet	Search...
Other
NextBio	85479.
SOURCE	Search...

Entry information

Entry name

ODFP4_HUMAN

Accession

Primary (citable) accession number: Q2M2E3
Secondary accession number(s): Q8J021

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.