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Protein

Outer dense fiber protein 4

Gene

ODF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 4
Alternative name(s):
Outer dense fiber of sperm tails protein 4
Testis-specific protein oppo 1
Short name:
hOPPO1
Gene namesi
Name:ODF4
Synonyms:OPPO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000184650.9.
HGNCiHGNC:19056. ODF4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi146852.
OpenTargetsiENSG00000184650.
PharmGKBiPA134978853.

Polymorphism and mutation databases

BioMutaiODF4.
DMDMi158564291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003047221 – 257Outer dense fiber protein 4Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2M2E3.
PRIDEiQ2M2E3.

PTM databases

iPTMnetiQ2M2E3.
PhosphoSitePlusiQ2M2E3.

Expressioni

Tissue specificityi

Expressed in testis and sperm; especially localized to sperm tail (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000184650.
CleanExiHS_ODF4.
ExpressionAtlasiQ2M2E3. baseline and differential.
GenevisibleiQ2M2E3. HS.

Interactioni

Protein-protein interaction databases

BioGridi127017. 5 interactors.
IntActiQ2M2E3. 3 interactors.
STRINGi9606.ENSP00000331086.

Structurei

3D structure databases

ProteinModelPortaliQ2M2E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZV4. Eukaryota.
ENOG4111BHV. LUCA.
GeneTreeiENSGT00390000003542.
HOGENOMiHOG000115258.
InParanoidiQ2M2E3.
OMAiLFPINIW.
OrthoDBiEOG091G0NXG.
PhylomeDBiQ2M2E3.
TreeFamiTF338228.

Sequencei

Sequence statusi: Complete.

Q2M2E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAEYSGNEF PRSEGERDQH QRPGKERKSG EAGWGTGELG QDGRLLSSTL
60 70 80 90 100
SLSSNRSLGQ RQNSPLPFQW RITHSFRWMA QVLASELSLV AFILLLVVAF
110 120 130 140 150
SKKWLDLSRS LFYQRWPVDV SNRIHTSAHV MSMGLLHFYK SRSCSDLENG
160 170 180 190 200
KVTFIFSTLM LFPINIWIFE LERNVSIPIG WSYFIGWLVL ILYFTCAILC
210 220 230 240 250
YFNHKSFWSL ILSHPSGAVS CSSSFGSVEE SPRAQTITDT PITQEGVLDP

EQKDTHV
Length:257
Mass (Da):29,233
Last modified:September 11, 2007 - v2
Checksum:iB0E743E89798BA39
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03506034W → R1 PublicationCorresponds to variant dbSNP:rs12943505Ensembl.1
Natural variantiVAR_03506198V → M3 PublicationsCorresponds to variant dbSNP:rs12601097Ensembl.1
Natural variantiVAR_035062139Y → C3 PublicationsCorresponds to variant dbSNP:rs12936935Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081120 mRNA. Translation: BAC15594.1.
AY237799 mRNA. Translation: AAO89569.1.
BC112010 mRNA. Translation: AAI12011.1.
BC112014 mRNA. Translation: AAI12015.1.
CCDSiCCDS11140.1.
RefSeqiNP_694552.2. NM_153007.4.
UniGeneiHs.186045.

Genome annotation databases

EnsembliENST00000328248; ENSP00000331086; ENSG00000184650.
GeneIDi146852.
KEGGihsa:146852.
UCSCiuc002gle.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiODFP4_HUMAN
AccessioniPrimary (citable) accession number: Q2M2E3
Secondary accession number(s): Q8J021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 27, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot