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Protein

Zinc finger protein 630

Gene

ZNF630

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 630
Gene namesi
Name:ZNF630
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28855. ZNF630.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889031.

Polymorphism and mutation databases

BioMutaiZNF630.
DMDMi97219357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Zinc finger protein 630PRO_0000234603Add
BLAST

Proteomic databases

PaxDbiQ2M218.
PRIDEiQ2M218.

PTM databases

iPTMnetiQ2M218.
PhosphoSiteiQ2M218.

Expressioni

Gene expression databases

BgeeiQ2M218.
CleanExiHS_ZNF630.
ExpressionAtlasiQ2M218. baseline and differential.
GenevisibleiQ2M218. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386393.

Structurei

3D structure databases

ProteinModelPortaliQ2M218.
SMRiQ2M218. Positions 8-48, 233-654.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ2M218.
KOiK09228.
OMAiRKSQMIT.
PhylomeDBiQ2M218.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2M218-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIESQEPVTF EDVAVDFTQE EWQQLNPAQK TLHRDVMLET YNHLVSVGCS
60 70 80 90 100
GIKPDVIFKL EHGKDPWIIE SELSRWIYPD RVKGLESSQQ IISGELLFQR
110 120 130 140 150
EILERAPKDN SLYSVLKIWH IDNQMDRYQG NQDRVLRQVT VISRETLTDE
160 170 180 190 200
MGSKYSAFGK MFNRCTDLAP LSQKFHKFDS CENSLKSNSD LLNYNRSYAR
210 220 230 240 250
KNPTKRFRCG RPPKYNASCS VPEKEGFIHT GMEPYGDSQC EKVLSHKQAH
260 270 280 290 300
VQYKKFQARE KPNVCSMCGK AFIKKSQLII HQRIHTGEKP YVCGDCRKAF
310 320 330 340 350
SEKSHLIVHQ RIHTGEKPYE CTKYGRAFSR KSPFTVHQRV HTGEKPYECF
360 370 380 390 400
ECPKAFSQKS HLIIHQRVHT REKPFECSEC RKAFCEMSHL FIHQITHTGK
410 420 430 440 450
KPYECTECGK TFPRKTQLII HQRTHTGEKP YKCGECGKTF CQQSHLIGHQ
460 470 480 490 500
RIHTGEKPYV CTDCGKAFSQ KSHLTGHQRL HTGEKPYMCT ECGKSFSQKS
510 520 530 540 550
PLIIHQRIHT GEKPYQCGEC GKTFSQKSLL IIHLRVHTGE KPYECTECGR
560 570 580 590 600
AFSLKSHLIL HQRGHTGEKP YECSECGKAF CGKSPLIIHQ KTHPREKTPE
610 620 630 640 650
CAESGMTFFW KSQMITYQRR HTGEKPSRCS DCGKAFCQHV YFTGHQNPYR

KDTLYIC
Length:657
Mass (Da):76,094
Last modified:February 21, 2006 - v1
Checksum:i0902CC9CE709EE7B
GO
Isoform 2 (identifier: Q2M218-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-20: Missing.

Note: No experimental confirmation available.
Show »
Length:643
Mass (Da):74,515
Checksum:i4BE547F926940384
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461T → H in BX419623 (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei7 – 2014Missing in isoform 2. 1 PublicationVSP_046855Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98304 Genomic DNA. Translation: CAI42941.2.
CH471164 Genomic DNA. Translation: EAW59337.1.
BC112139 mRNA. Translation: AAI12140.3.
BX419623 mRNA. No translation available.
CCDSiCCDS35237.2. [Q2M218-1]
RefSeqiNP_001032824.2. NM_001037735.3. [Q2M218-1]
NP_001177184.1. NM_001190255.2. [Q2M218-2]
NP_001269130.1. NM_001282201.1. [Q2M218-1]
NP_001269131.1. NM_001282202.1.
UniGeneiHs.650883.

Genome annotation databases

EnsembliENST00000409324; ENSP00000386393; ENSG00000221994. [Q2M218-1]
ENST00000442455; ENSP00000393163; ENSG00000221994. [Q2M218-1]
GeneIDi57232.
KEGGihsa:57232.
UCSCiuc004div.5. human. [Q2M218-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98304 Genomic DNA. Translation: CAI42941.2.
CH471164 Genomic DNA. Translation: EAW59337.1.
BC112139 mRNA. Translation: AAI12140.3.
BX419623 mRNA. No translation available.
CCDSiCCDS35237.2. [Q2M218-1]
RefSeqiNP_001032824.2. NM_001037735.3. [Q2M218-1]
NP_001177184.1. NM_001190255.2. [Q2M218-2]
NP_001269130.1. NM_001282201.1. [Q2M218-1]
NP_001269131.1. NM_001282202.1.
UniGeneiHs.650883.

3D structure databases

ProteinModelPortaliQ2M218.
SMRiQ2M218. Positions 8-48, 233-654.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386393.

PTM databases

iPTMnetiQ2M218.
PhosphoSiteiQ2M218.

Polymorphism and mutation databases

BioMutaiZNF630.
DMDMi97219357.

Proteomic databases

PaxDbiQ2M218.
PRIDEiQ2M218.

Protocols and materials databases

DNASUi57232.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409324; ENSP00000386393; ENSG00000221994. [Q2M218-1]
ENST00000442455; ENSP00000393163; ENSG00000221994. [Q2M218-1]
GeneIDi57232.
KEGGihsa:57232.
UCSCiuc004div.5. human. [Q2M218-1]

Organism-specific databases

CTDi57232.
GeneCardsiZNF630.
HGNCiHGNC:28855. ZNF630.
MIMi300819. gene.
neXtProtiNX_Q2M218.
PharmGKBiPA134889031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ2M218.
KOiK09228.
OMAiRKSQMIT.
PhylomeDBiQ2M218.
TreeFamiTF337898.

Miscellaneous databases

GenomeRNAii57232.
PROiQ2M218.
SOURCEiSearch...

Gene expression databases

BgeeiQ2M218.
CleanExiHS_ZNF630.
ExpressionAtlasiQ2M218. baseline and differential.
GenevisibleiQ2M218. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-146 (ISOFORM 2).
    Tissue: Fetal brain.

Entry informationi

Entry nameiZN630_HUMAN
AccessioniPrimary (citable) accession number: Q2M218
Secondary accession number(s): F8WAG4, Q5H8Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 21, 2006
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.