Q2M1P5 (KIF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF7

Gene names

Name:	KIF7
ORF Names:	UNQ340/PRO539

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1343 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as both a negative and positive regulator of sonic hedgehog (Shh) pathway, acting downstream of SMO. Negatively regulates the pathway by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates the pathway by preventing the processing of the transcription factor GLI3 into its repressor form. Required for efficient localization of GLI3 to cilia in response to Shh. Affects microtubular dynamics and acts as a ciliary motor. Ref.8
Subunit structure	Interacts with GLI1, GLI2, GLI3, SMO and SUFU. Interacts with NPHP1. Ref.6 Ref.8
Subcellular location	Cell projection › cilium. Note: SMO is required for its accumulation within cilia. Moves from the cilia base to the cilia tip in response to activation of the Shh pathway. Ref.6
Tissue specificity	Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. Ref.8
Involvement in disease	Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. The ciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome, and hydrolethalus syndrome among others. Single-locus allelism is insufficient to explain the variable penetrance and expressivity of such disorders, leading to the suggestion that variations across multiple sites of the ciliary proteome influence the clinical outcome. Primary ciliopathy loci can be modulated by pathogenic lesions in other ciliary genes to either exacerbate overall severity or induce specific endophenotypes. KIF7 may be causally associated with diverse ciliopathies, and also acts as a modifier gene across the ciliopathy spectrum. Bardet-Biedl syndrome (BBS) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Note: The gene represented in this entry may act as a disease modifier. Heterozygous missense mutations in KIF7 may genetically interact with other BBS genes and contribute to disease manifestation and severity. Ref.9 Hydrolethalus syndrome 2 (HLS2) [MIM:614120]: An embryonic lethal disorder characterized by hydrocephaly or anencephaly, postaxial polydactyly of the upper limbs, and pre- or postaxial polydactyly of the lower limbs. Duplication of the hallux is a common finding. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Acrocallosal syndrome (ACLS) [MIM:200990]: A syndrome characterized by hypogenesis or agenesis of the corpus callosum. Clinical features include postaxial polydactyly, hallux duplication, macrocephaly, craniofacial abnormalities, severe developmental delay and mental retardation. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Joubert syndrome 12 (JBTS12) [MIM:200990]: A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Pallister-Hall syndrome (PHS) [MIM:146510]: An autosomal dominant disorder characterized by a wide range of clinical manifestations. Clinical features include hypothalamic hamartoma, pituitary dysfunction, central or postaxial polydactyly, and syndactyly. Malformations are frequent in the viscera, e.g. anal atresia, bifid uvula, congenital heart malformations, pulmonary or renal dysplasia. Note: The gene represented in this entry may be involved in disease pathogenesis. Ref.9
Sequence similarities	Belongs to the kinesin-like protein family. KIF27 subfamily. Contains 1 kinesin-motor domain.
Sequence caution	The sequence AAI04045.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI12272.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI12274.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAQ88750.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cell projection Cilium
Coding sequence diversity	Polymorphism
Disease	Bardet-Biedl syndrome Ciliopathy Disease mutation Joubert syndrome Mental retardation Obesity
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro negative regulation of smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cilium Inferred from direct assay Ref.6. Source: UniProtKB microtubule associated complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from direct assay Ref.8. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1343

1343

Kinesin-like protein KIF7

PRO_0000307146

Regions

Domain

12 – 277

266

Kinesin-motor

Nucleotide binding

94 – 101

8

ATP Potential

Region

513 – 775

263

Sufficient for interaction with NPHP1

Coiled coil

480 – 542

63

Potential

Coiled coil

698 – 1057

360

Potential

Coiled coil

1109 – 1211

103

Potential

Compositional bias

395 – 402

8

Poly-Ala

Compositional bias

624 – 631

8

Poly-Glu

Natural variations

Natural variant

52

1

D → N.
Corresponds to variant rs8179065 [ dbSNP | Ensembl ].

VAR_061287

Natural variant

632

1

P → L in PHS; hypomorphic mutation in vitro. Ref.9

VAR_066450

Natural variant

641

1

R → G in BBS; hypomorphic variant in vitro; may affect splicing; the patient also carries homozygous mutation R-390 in BBS1. Ref.9

VAR_066451

Natural variant

702

1

R → Q in ACLS; hypomorphic mutation in vitro; may affect splicing. Ref.9

VAR_066452

Natural variant

759

1

L → P Found as heterozygous variant in a patient with Bardet-Biedl syndrome; hypomorphic variant in vitro. Ref.9

VAR_066453

Natural variant

834

1

Q → R Rare variant found in a patient with Bardet-Biedl syndrome also carrying a frameshift mutation in BBS10 and variant P-293 in BBS7. Ref.9
Corresponds to variant rs138354681 [ dbSNP | Ensembl ].

VAR_066454

Natural variant

958

1

S → I. Ref.3
Corresponds to variant rs3803530 [ dbSNP | Ensembl ].

VAR_035363

Natural variant

994

1

Q → R in BBS; hypomorphic variant in vitro; the patient is a compound heterozygote for a truncating mutation and mutation R-390 in BBS1. Ref.9

VAR_066455

Natural variant

1005

1

G → R. Ref.3
Corresponds to variant rs12900805 [ dbSNP | Ensembl ].

VAR_035364

Natural variant

1068

1

R → W in BBS; hypomorphic variant in vitro; the patient is a compound heterozygote for two frameshift mutations in BBS9. Ref.9

VAR_066456

Natural variant

1115

1

H → Q in HLS2; also found in a patient with Meckel-Gruber syndrome; hypomorphic variant in vitro. Ref.9

VAR_066457

Natural variant

1329 – 1332

4

Missing in JBTS12; found in a patient with Joubert syndrome that also carries mutations L-358 and T-833 in TMEM67.

VAR_066458

Experimental info

Sequence conflict

548

1

P → L in AAQ88750. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1343

Helix Strand Turn

Details...

Beta strand

17 – 22

6

Helix

27 – 31

5

Beta strand

38 – 41

4

Helix

42 – 44

3

Beta strand

46 – 49

4

Turn

50 – 52

3

Beta strand

53 – 56

4

Beta strand

58 – 61

4

Helix

67 – 74

8

Helix

76 – 83

8

Beta strand

88 – 95

8

Helix

100 – 104

5

Helix

119 – 133

15

Beta strand

137 – 149

13

Beta strand

152 – 155

4

Helix

163 – 165

3

Beta strand

167 – 170

4

Beta strand

176 – 180

5

Helix

189 – 204

16

Helix

214 – 216

3

Beta strand

217 – 228

12

Beta strand

243 – 252

10

Helix

278 – 289

12

Turn

292 – 296

5

Helix

301 – 303

3

Helix

305 – 309

5

Turn

310 – 312

3

Beta strand

313 – 315

3

Beta strand

318 – 326

9

Helix

330 – 332

3

Helix

333 – 345

13

Sequences

	Sequence		Length	Mass (Da)
	Q2M1P5 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 5217A6F36C156587	FASTA	1,343	150,587
	10 20 30 40 50 60 MGLEAQRLPG AEEAPVRVAL RVRPLLPKEL LHGHQSCLQV EPGLGRVTLG RDRHFGFHVV 70 80 90 100 110 120 LAEDAGQEAV YQACVQPLLE AFFEGFNATV FAYGQTGSGK TYTMGEASVA SLLEDEQGIV 130 140 150 160 170 180 PRAMAEAFKL IDENDLLDCL VHVSYLEVYK EEFRDLLEVG TASRDIQLRE DERGNVVLCG 190 200 210 220 230 240 VKEVDVEGLD EVLSLLEMGN AARHTGATHL NHLSSRSHTV FTVTLEQRGR APSRLPRPAP 250 260 270 280 290 300 GQLLVSKFHF VDLAGSERVL KTGSTGERLK ESIQINSSLL ALGNVISALG DPQRRGSHIP 310 320 330 340 350 360 YRDSKITRIL KDSLGGNAKT VMIACVSPSS SDFDETLNTL NYASRAQNIR NRATVNWRPE 370 380 390 400 410 420 AERPPEETAS GARGPPRHRS ETRIIHRGRR APGPATASAA AAMRLGAECA RYRACTDAAY 430 440 450 460 470 480 SLLRELQAEP GLPGAAARKV RDWLCAVEGE RSALSSASGP DSGIESASVE DQAAQGAGGR 490 500 510 520 530 540 KEDEGAQQLL TLQNQVARLE EENRDFLAAL EDAMEQYKLQ SDRLREQQEE MVELRLRLEL 550 560 570 580 590 600 VRPGWGGPRL LNGLPPGSFV PRPHTAPLGG AHAHVLGMVP PACLPGDEVG SEQRGEQVTN 610 620 630 640 650 660 GREAGAELLT EVNRLGSGSS AASEEEEEEE EPPRRTLHLR RNRISNCSQR AGARPGSLPE 670 680 690 700 710 720 RKGPELCLEE LDAAIPGSRA VGGSKARVQA RQVPPATASE WRLAQAQQKI RELAINIRMK 730 740 750 760 770 780 EELIGELVRT GKAAQALNRQ HSQRIRELEQ EAEQVRAELS EGQRQLRELE GKELQDAGER 790 800 810 820 830 840 SRLQEFRRRV AAAQSQVQVL KEKKQATERL VSLSAQSEKR LQELERNVQL MRQQQGQLQR 850 860 870 880 890 900 RLREETEQKR RLEAEMSKRQ HRVKELELKH EQQQKILKIK TEEIAAFQRK RRSGSNGSVV 910 920 930 940 950 960 SLEQQQKIEE QKKWLDQEME KVLQQRRALE ELGEELHKRE AILAKKEALM QEKTGLESKR 970 980 990 1000 1010 1020 LRSSQALNED IVRVSSRLEH LEKELSEKSG QLRQGSAQSQ QQIRGEIDSL RQEKDSLLKQ 1030 1040 1050 1060 1070 1080 RLEIDGKLRQ GSLLSPEEER TLFQLDEAIE ALDAAIEYKN EAITCRQRVL RASASLLSQC 1090 1100 1110 1120 1130 1140 EMNLMAKLSY LSSSETRALL CKYFDKVVTL REEQHQQQIA FSELEMQLEE QQRLVYWLEV 1150 1160 1170 1180 1190 1200 ALERQRLEMD RQLTLQQKEH EQNMQLLLQQ SRDHLGEGLA DSRRQYEARI QALEKELGRY 1210 1220 1230 1240 1250 1260 MWINQELKQK LGGVNAVGHS RGGEKRSLCS EGRQAPGNED ELHLAPELLW LSPLTEGAPR 1270 1280 1290 1300 1310 1320 TREETRDLVH APLPLTWKRS SLCGEEQGSP EELRQREAAE PLVGRVLPVG EAGLPWNFGP 1330 1340 LSKPRRELRR ASPGMIDVRK NPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 453-1343.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 462-1343, VARIANTS ILE-958 AND ARG-1005. Tissue: Heart, Lung and Ovary.
[4]	"Characterization of KIF7 gene in silico." Katoh Y., Katoh M. Int. J. Oncol. 25:1881-1886(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development." Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S. Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH GLI1; GLI2; GLI3; SMO AND SUFU.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics." Dafinger C., Liebau M.C., Elsayed S.M., Hellenbroich Y., Boltshauser E., Korenke G.C., Fabretti F., Janecke A.R., Ebermann I., Nurnberg G., Nurnberg P., Zentgraf H., Koerber F., Addicks K., Elsobky E., Benzing T., Schermer B., Bolz H.J. J. Clin. Invest. 121:2662-2667(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH NPHP1, TISSUE SPECIFICITY, VARIANT JBTS12 1329-ARG--SER-1332 DEL.
[9]	"KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes." Putoux A., Thomas S., Coene K.L., Davis E.E., Alanay Y., Ogur G., Uz E., Buzas D., Gomes C., Patrier S., Bennett C.L., Elkhartoufi N., Frison M.H., Rigonnot L., Joye N., Pruvost S., Utine G.E., Boduroglu K. , Nitschke P., Fertitta L., Thauvin-Robinet C., Munnich A., Cormier-Daire V., Hennekam R., Colin E., Akarsu N.A., Bole-Feysot C., Cagnard N., Schmitt A., Goudin N., Lyonnet S., Encha-Razavi F., Siffroi J.P., Winey M., Katsanis N., Gonzales M., Vekemans M., Beales P.L., Attie-Bitach T. Nat. Genet. 43:601-606(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CILIOPATHIES, VARIANT PHS LEU-632, VARIANTS BBS GLY-641; ARG-994 AND TRP-1068, VARIANT ACLS GLN-702, VARIANT HLS2 GLN-1115, VARIANTS PRO-759 AND ARG-834, CHARACTERIZATION OF VARIANTS VARIANT PHS LEU-632, CHARACTERIZATION OF VARIANTS BBS GLY-641; ARG-994 AND TRP-1068, CHARACTERIZATION OF VARIANT ACLS GLN-702, CHARACTERIZATION OF VARIANT HLS2 GLN-1115, CHARACTERIZATION OF VARIANTS PRO-759 AND ARG-834.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC079075 Genomic DNA. No translation available.
AY358384 mRNA. Translation: AAQ88750.1. Different initiation.
BC040878 mRNA. Translation: AAH40878.1.
BC104044 mRNA. Translation: AAI04045.1. Different initiation.
BC112271 mRNA. Translation: AAI12272.1. Different initiation.
BC112273 mRNA. Translation: AAI12274.1. Different initiation.

IPI

IPI00394856.

RefSeq

NP_940927.2. NM_198525.2.

UniGene

Hs.513134.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2XT3	X-ray	1.88	A	8-347	[»]
4A14	X-ray	1.60	A	8-347	[»]

ProteinModelPortal

Q2M1P5.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q2M1P5. 1 interaction.

MINT

MINT-6774537.

STRING

9606.ENSP00000377934.

PTM databases

PhosphoSite

Q2M1P5.

Polymorphism databases

DMDM

172045866.

Proteomic databases

PaxDb

Q2M1P5.

PRIDE

Q2M1P5.

Protocols and materials databases

DNASU

374654.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000394412; ENSP00000377934; ENSG00000166813.

GeneID

374654.

KEGG

hsa:374654.

UCSC

uc002bof.2. human.

Organism-specific databases

CTD

374654.

GeneCards

GC15M090171.

H-InvDB

HIX0038116.

HGNC

HGNC:30497. KIF7.

HPA

HPA043145.

MIM

146510. phenotype.
200990. phenotype.
209900. phenotype.
611254. gene.
614120. phenotype.

neXtProt

NX_Q2M1P5.

Orphanet

36. Acrocallosal syndrome.
2189. Hydrolethalus.
475. Joubert syndrome.
220493. Joubert syndrome with ocular defect.
2754. Joubert syndrome with orofaciodigital defect.
166024. Multiple epiphyseal dysplasia, Al-Gazali type.

PharmGKB

PA134871338.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5059.

HOGENOM

HOG000068072.

HOVERGEN

HBG054858.

InParanoid

Q2M1P5.

KO

K10395.

OMA

MEQYKQQ.

OrthoDB

EOG4CG07C.

Gene expression databases

ArrayExpress

Q2M1P5.

Bgee

Q2M1P5.

CleanEx

HS_KIF7.

Genevestigator

Q2M1P5.

Family and domain databases

Gene3D

3.40.850.10. 1 hit.

InterPro

IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
[Graphical view]

Pfam

PF00225. Kinesin. 1 hit.
[Graphical view]

PRINTS

PR00380. KINESINHEAVY.

SMART

SM00129. KISc. 1 hit.
[Graphical view]

PROSITE

PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

374654.

NextBio

100233.

SOURCE

Search...

Entry information

Entry name

KIF7_HUMAN

Accession

Primary (citable) accession number: Q2M1P5
Secondary accession number(s): Q3SXY0, Q6UXE9, Q8IW72

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.