ID Q2M1J3_HUMAN Unreviewed; 1607 AA. AC Q2M1J3; DT 21-FEB-2006, integrated into UniProtKB/TrEMBL. DT 21-FEB-2006, sequence version 1. DT 27-MAR-2024, entry version 107. DE SubName: Full=ROBO1 protein {ECO:0000313|EMBL:AAI12337.1}; GN Name=ROBO1 {ECO:0000313|EMBL:AAI12337.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI12337.1}; RN [1] {ECO:0000313|EMBL:AAI12337.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q2M1J3; Q8N7X4: MAGEB6; NbExp=3; IntAct=EBI-18191632, EBI-6447163; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC112336; AAI12337.1; -; mRNA. DR SMR; Q2M1J3; -. DR IntAct; Q2M1J3; 1. DR PeptideAtlas; Q2M1J3; -. DR ChiTaRS; ROBO1; human. DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro. DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro. DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro. DR CDD; cd00063; FN3; 3. DR CDD; cd07693; IgC_1_Robo; 1. DR CDD; cd05724; IgI_2_Robo; 1. DR CDD; cd05725; IgI_3_Robo; 1. DR CDD; cd05726; IgI_4_Robo; 1. DR CDD; cd20952; IgI_5_Robo; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 8. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR032986; Robo1_Ig-like3. DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1. DR PANTHER; PTHR44170:SF9; ROUNDABOUT GUIDANCE RECEPTOR 1; 1. DR Pfam; PF00041; fn3; 3. DR Pfam; PF07679; I-set; 2. DR Pfam; PF13927; Ig_3; 3. DR SMART; SM00060; FN3; 3. DR SMART; SM00409; IG; 5. DR SMART; SM00408; IGc2; 5. DR SMART; SM00406; IGv; 2. DR SUPFAM; SSF49265; Fibronectin type III; 2. DR SUPFAM; SSF48726; Immunoglobulin; 5. DR PROSITE; PS50853; FN3; 3. DR PROSITE; PS50835; IG_LIKE; 5. PE 1: Evidence at protein level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 29..125 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 131..218 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 223..307 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 315..410 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 419..505 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 527..621 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 640..737 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT DOMAIN 742..838 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" FT REGION 1079..1158 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1180..1293 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1308..1353 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1376..1607 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1088..1121 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1207..1227 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1249..1264 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1313..1353 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1394..1411 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1472..1495 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1510..1533 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1546..1577 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1607 AA; 175893 MW; 19F15DB1F218810B CRC64; MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYVCVA RNYLGEAVSH NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA EASATLTVQV GSEPPHFVVK PRDQVVALGR TVTFQCEATG NPQPAIFWRR EGSQNLLFSY QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY ICQTLNVAGS IITKAYLEVT DVIADRPPPV IRQGPVNQTV AVDGTFVLSC VATGSPVPTI LWRKDGVLVS TQDSRIKQLE NGVLQIRYAK LGDTGRYTCI ASTPSGEATW SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT VTLSWQPNLN SGATPTSYII EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA ANAYGISDPS QISDPVKTQD VLPTSQGVDH KQVQRELGNA VLHLHNPTVL SSSSIEVHWT VDQQSQYIQG YKILYRPSGA NHGESDWLVF EVRTPAKNSV VIPDLRKGVN YEIKARPFFN EFQGADSEIK FAKTLEEAPS APPQGVTVSK NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW CLGNETRYHI NKTVDGSTFS VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN PVSPEDQVSL AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR KVTYQRGGEA VSSGGRPGLL NISEPAAQPW LADTWPNTGN NHNDCSISCC TAGNGNSDSN LTTYSRPADC IANYNNQLDN KQTNLMLPES TVYGDVDLSN KINEMKTFNS PNLKDGRFVN PSGQPTPYAT TQLIQSNLSN NMNNGSGDSG EKHWKPLGQQ KQEVAPVQYN IVEQNKLNKD YRANDTVPPT IPYNQSYDQN TGGSYNSSDR GSSTSGSQGH KKGGARTPKV PKQGGMNWAD LLPPPPAHPP PHSNSEEYNI SVDESYDQEM PCPVPPARMY LQQDELEEEE DERGPTPPVR GAASSPAAVS YSHQSTATLT PSPQEELQPM LQDCPEETGH MQHQPDRRRQ PVSPPPPPRP ISPPHTYGYI SGPLVSDMDT DAPEEEEDEA DMEVAKMQTR RLLLRGLEQT PASSVGDLES SVTGSMINGW GSASEEDNIS SGRSSVSSSD GSFFTDADFA QAVAAAAEYA GLKVARRQMQ DAAGRRHFHA SQCPRPTSPV STDSNMSAAV MQKTRPAKKL KHQPGHLRRE TYTDDLPPPP VPPPAIKSPT AQSKTQLEVR PVVVPKLPSM DARTDRSSDR KGSSYKGREV LDGRQVVDMR TNPGDPREAQ EQQNDGKGRG NKAAKRDLPP AKTHLIQEDI LPYCRPTFPT SNNPRDPSSS SSMSSRGSGS RQREQANVGR RNIAEMQVLG GYERGEDNNE ELEETES //