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Q2M1H9

- Q2M1H9_HUMAN

UniProt

Q2M1H9 - Q2M1H9_HUMAN

Protein
Submitted name:

Heparanase 2

Gene

HPSE2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. hydrolase activity, acting on glycosyl bonds Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Heparanase 2Imported
    Gene namesi
    Name:HPSE2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38533.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ2M1H9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2M1H9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG081606.
    KOiK07965.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR005199. Glyco_hydro_79.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR14363. PTHR14363. 1 hit.
    PfamiPF03662. Glyco_hydro_79n. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q2M1H9-1 [UniParc]FASTAAdd to Basket

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    MRVLCAFPEA MPSSNSRPPA CLAPGALYLA LLLHLSLSSQ AGDRRPLPVD    50
    RAAGLKEKTL ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR 100
    LVTLARGLSP AFLRFGGKRT DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD 150
    IVRSDVALDK QKGCKIAQHP DVMLELQREK AAQMHLVLLK EQFSNTYSNL 200
    ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS ALSLLKYSAS 250
    KKYNISWELG NEPNNYRTMH GRAVNGSQLG KDYIQLKSLL QPIRIYSRAS 300
    LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK 350
    TRLLDTLSDQ IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG 400
    FLWLNTLGML ANQGIDVVIR HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR 450
    LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI YAHCTNHHNH NYVRGSITLF 500
    IINLHRSRKK IKLTGTLRDK LVHQYLLQPY GQEGLKSKSV QLNGQPLVMV 550
    DDGTLPELKP RPLRAGRTLV IPPVTMGFFV VKNVNALACR YR 592
    Length:592
    Mass (Da):66,610
    Last modified:February 21, 2006 - v1
    Checksum:i94689E1C2A74359F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112356 mRNA. Translation: AAI12357.1.
    RefSeqiNP_068600.4. NM_021828.4.
    UniGeneiHs.500750.
    Hs.676960.
    Hs.689544.

    Genome annotation databases

    GeneIDi60495.
    KEGGihsa:60495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112356 mRNA. Translation: AAI12357.1 .
    RefSeqi NP_068600.4. NM_021828.4.
    UniGenei Hs.500750.
    Hs.676960.
    Hs.689544.

    3D structure databases

    ProteinModelPortali Q2M1H9.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2M1H9.

    Protocols and materials databases

    DNASUi 60495.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 60495.
    KEGGi hsa:60495.

    Organism-specific databases

    CTDi 60495.
    PharmGKBi PA38533.

    Phylogenomic databases

    HOVERGENi HBG081606.
    KOi K07965.

    Miscellaneous databases

    GenomeRNAii 60495.
    NextBioi 65399.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR005199. Glyco_hydro_79.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR14363. PTHR14363. 1 hit.
    Pfami PF03662. Glyco_hydro_79n. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiQ2M1H9_HUMAN
    AccessioniPrimary (citable) accession number: Q2M1H9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 21, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.