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Q2LZB1

- UBP36_DROPS

UniProt

Q2LZB1 - UBP36_DROPS

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei180 – 1801NucleophilePROSITE-ProRule annotation
    Active sitei438 – 4381Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GA18934
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0078933. Dpse\GA18934.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10591059Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378500Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei508 – 5081PhosphoserineBy similarity
    Modified residuei510 – 5101PhosphoserineBy similarity
    Modified residuei673 – 6731PhosphothreonineBy similarity
    Modified residuei682 – 6821PhosphothreonineBy similarity
    Modified residuei692 – 6921PhosphoserineBy similarity
    Modified residuei694 – 6941PhosphoserineBy similarity
    Modified residuei766 – 7661PhosphoserineBy similarity
    Modified residuei801 – 8011PhosphoserineBy similarity
    Modified residuei804 – 8041PhosphothreonineBy similarity
    Modified residuei807 – 8071PhosphoserineBy similarity
    Modified residuei846 – 8461PhosphothreonineBy similarity
    Modified residuei861 – 8611PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Protein-protein interaction databases

    STRINGi7237.FBpp0274209.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini171 – 479309USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    InParanoidiQ2LZB1.
    KOiK11855.
    OrthoDBiEOG7XDBF6.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LZB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSMAVCET ANVVNAALRE SLGVGNGSRA ADEAKKTGGG GGDDSDSEMH     50
    NQIAVSAYAK RILMSKIEYE EVPNYHDSVL EQLKNKYIVI KQPSNNNNSS 100
    SCNGSNFGNS KVVGANGHDN GNNGHRKLTQ SESTQSGPSP NELPKPKRVL 150
    YPRENIRIGW KQSERKWQVG TGMINVGNTC YLNSTLQALF HIPALANWLV 200
    SEQTHLENCN ITESNGGCII CAMAKTLQST QSCQSAMRPF HIYSKLKQIC 250
    KHMVVGRQED AHEFLRFLVE AMEKAYLMRF RNFKELDQLV KETTPLNQIF 300
    GGYLRSEVRC LSCSHVSITF QHFQDLLLDI RKSDTLEEAF DGYFSRERLE 350
    DMGYKCEGCK KKVSATKQFS LERAPITLCI QLKRFSMIGN KLTKTISFKP 400
    RIDLSRFAAR SPAAAAQPLT YRLVSMVTHL GVSQHCGHYT AIGMTESGSY 450
    YNFDDSYVRP IAMQSVCNTN AYIMFYELDL SQTTPLKSNG LRLTNGHSQV 500
    AVPATVSSSS PTHTRFIGPQ LPPGGINGYS NGHATGSSNA QKTAIQFKQQ 550
    QQHPQQNGLQ VGTGKFQEPP HAKSPLAGAY NKGEAFPATT ANGNKSSSSS 600
    ASNSNHNKSV NQLQHQQHYL PISSEDEDSE DGATATATAT ATARPTAQLP 650
    SMPKMTEDSS DKPKTPLKSS VKTNLVKSLL KTPLKSLVPY ESASEEDEPL 700
    PNPRKRRSDS DSNDSGDSDP QPGHVNGHTK TNGGSLTNGN GLGKAKTILA 750
    TSSSSSLASA SASAASDDED ADEEEENSKL TNGWQPQKQS QSLTQSKAPP 800
    SPKTPPSPAV IKSKTGIWKV TRNDDNEDED DDDDEDEEEQ HQVVSTPSKN 850
    PRNPFAKSST TPGAKRQKLL NGIAVKSQQQ PRVGNGYQSE ASTNGNVVNE 900
    LLKQTHRGYG SASVLSWSGK PAELEKELVA EAREQRQHDH DDEEENEMDR 950
    GRQRKVKSAT AKAYNSSTPG YNPFQEYESQ KRWHKSSNGG GSFPRYHNQN 1000
    FRQNFQQRNK FKYNRFGGPG GAKFQQQRAL QRHLASGGVF NRRQPTGQQQ 1050
    QQQSQQSSS 1059
    Length:1,059
    Mass (Da):116,372
    Last modified:October 14, 2008 - v2
    Checksum:iA479D84A1DBFE65D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379069 Genomic DNA. Translation: EAL29597.2.
    RefSeqiXP_001353862.2. XM_001353826.2.

    Genome annotation databases

    EnsemblMetazoaiFBtr0275771; FBpp0274209; FBgn0078933.
    GeneIDi4813226.
    KEGGidpo:Dpse_GA18934.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379069 Genomic DNA. Translation: EAL29597.2 .
    RefSeqi XP_001353862.2. XM_001353826.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0274209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0275771 ; FBpp0274209 ; FBgn0078933 .
    GeneIDi 4813226.
    KEGGi dpo:Dpse_GA18934.

    Organism-specific databases

    FlyBasei FBgn0078933. Dpse\GA18934.

    Phylogenomic databases

    eggNOGi COG5533.
    InParanoidi Q2LZB1.
    KOi K11855.
    OrthoDBi EOG7XDBF6.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiUBP36_DROPS
    AccessioniPrimary (citable) accession number: Q2LZB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3