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Q2LZB1 (UBP36_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GA18934
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1059 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10591059Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378500

Regions

Domain171 – 479309USP

Sites

Active site1801Nucleophile By similarity
Active site4381Proton acceptor By similarity

Amino acid modifications

Modified residue5081Phosphoserine By similarity
Modified residue5101Phosphoserine By similarity
Modified residue6731Phosphothreonine By similarity
Modified residue6821Phosphothreonine By similarity
Modified residue6921Phosphoserine By similarity
Modified residue6941Phosphoserine By similarity
Modified residue7661Phosphoserine By similarity
Modified residue8011Phosphoserine By similarity
Modified residue8041Phosphothreonine By similarity
Modified residue8071Phosphoserine By similarity
Modified residue8461Phosphothreonine By similarity
Modified residue8611Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2LZB1 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: A479D84A1DBFE65D

FASTA1,059116,372
        10         20         30         40         50         60 
MPVSMAVCET ANVVNAALRE SLGVGNGSRA ADEAKKTGGG GGDDSDSEMH NQIAVSAYAK 

        70         80         90        100        110        120 
RILMSKIEYE EVPNYHDSVL EQLKNKYIVI KQPSNNNNSS SCNGSNFGNS KVVGANGHDN 

       130        140        150        160        170        180 
GNNGHRKLTQ SESTQSGPSP NELPKPKRVL YPRENIRIGW KQSERKWQVG TGMINVGNTC 

       190        200        210        220        230        240 
YLNSTLQALF HIPALANWLV SEQTHLENCN ITESNGGCII CAMAKTLQST QSCQSAMRPF 

       250        260        270        280        290        300 
HIYSKLKQIC KHMVVGRQED AHEFLRFLVE AMEKAYLMRF RNFKELDQLV KETTPLNQIF 

       310        320        330        340        350        360 
GGYLRSEVRC LSCSHVSITF QHFQDLLLDI RKSDTLEEAF DGYFSRERLE DMGYKCEGCK 

       370        380        390        400        410        420 
KKVSATKQFS LERAPITLCI QLKRFSMIGN KLTKTISFKP RIDLSRFAAR SPAAAAQPLT 

       430        440        450        460        470        480 
YRLVSMVTHL GVSQHCGHYT AIGMTESGSY YNFDDSYVRP IAMQSVCNTN AYIMFYELDL 

       490        500        510        520        530        540 
SQTTPLKSNG LRLTNGHSQV AVPATVSSSS PTHTRFIGPQ LPPGGINGYS NGHATGSSNA 

       550        560        570        580        590        600 
QKTAIQFKQQ QQHPQQNGLQ VGTGKFQEPP HAKSPLAGAY NKGEAFPATT ANGNKSSSSS 

       610        620        630        640        650        660 
ASNSNHNKSV NQLQHQQHYL PISSEDEDSE DGATATATAT ATARPTAQLP SMPKMTEDSS 

       670        680        690        700        710        720 
DKPKTPLKSS VKTNLVKSLL KTPLKSLVPY ESASEEDEPL PNPRKRRSDS DSNDSGDSDP 

       730        740        750        760        770        780 
QPGHVNGHTK TNGGSLTNGN GLGKAKTILA TSSSSSLASA SASAASDDED ADEEEENSKL 

       790        800        810        820        830        840 
TNGWQPQKQS QSLTQSKAPP SPKTPPSPAV IKSKTGIWKV TRNDDNEDED DDDDEDEEEQ 

       850        860        870        880        890        900 
HQVVSTPSKN PRNPFAKSST TPGAKRQKLL NGIAVKSQQQ PRVGNGYQSE ASTNGNVVNE 

       910        920        930        940        950        960 
LLKQTHRGYG SASVLSWSGK PAELEKELVA EAREQRQHDH DDEEENEMDR GRQRKVKSAT 

       970        980        990       1000       1010       1020 
AKAYNSSTPG YNPFQEYESQ KRWHKSSNGG GSFPRYHNQN FRQNFQQRNK FKYNRFGGPG 

      1030       1040       1050 
GAKFQQQRAL QRHLASGGVF NRRQPTGQQQ QQQSQQSSS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH379069 Genomic DNA. Translation: EAL29597.2.
RefSeqXP_001353862.2. XM_001353826.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0274209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0275771; FBpp0274209; FBgn0078933.
GeneID4813226.
KEGGdpo:Dpse_GA18934.

Organism-specific databases

FlyBaseFBgn0078933. Dpse\GA18934.

Phylogenomic databases

eggNOGCOG5533.
InParanoidQ2LZB1.
KOK11855.
OrthoDBEOG7XDBF6.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROPS
AccessionPrimary (citable) accession number: Q2LZB1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 14, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase