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Q2LZB1

- UBP36_DROPS

UniProt

Q2LZB1 - UBP36_DROPS

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene
Usp36, scny, GA18934
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei180 – 1801Nucleophile By similarity
Active sitei438 – 4381Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GA18934
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0078933. Dpse\GA18934.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei508 – 5081Phosphoserine By similarity
Modified residuei510 – 5101Phosphoserine By similarity
Modified residuei673 – 6731Phosphothreonine By similarity
Modified residuei682 – 6821Phosphothreonine By similarity
Modified residuei692 – 6921Phosphoserine By similarity
Modified residuei694 – 6941Phosphoserine By similarity
Modified residuei766 – 7661Phosphoserine By similarity
Modified residuei801 – 8011Phosphoserine By similarity
Modified residuei804 – 8041Phosphothreonine By similarity
Modified residuei807 – 8071Phosphoserine By similarity
Modified residuei846 – 8461Phosphothreonine By similarity
Modified residuei861 – 8611Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Protein-protein interaction databases

STRINGi7237.FBpp0274209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini171 – 479309USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiQ2LZB1.
KOiK11855.
OrthoDBiEOG7XDBF6.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LZB1-1 [UniParc]FASTAAdd to Basket

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MPVSMAVCET ANVVNAALRE SLGVGNGSRA ADEAKKTGGG GGDDSDSEMH     50
NQIAVSAYAK RILMSKIEYE EVPNYHDSVL EQLKNKYIVI KQPSNNNNSS 100
SCNGSNFGNS KVVGANGHDN GNNGHRKLTQ SESTQSGPSP NELPKPKRVL 150
YPRENIRIGW KQSERKWQVG TGMINVGNTC YLNSTLQALF HIPALANWLV 200
SEQTHLENCN ITESNGGCII CAMAKTLQST QSCQSAMRPF HIYSKLKQIC 250
KHMVVGRQED AHEFLRFLVE AMEKAYLMRF RNFKELDQLV KETTPLNQIF 300
GGYLRSEVRC LSCSHVSITF QHFQDLLLDI RKSDTLEEAF DGYFSRERLE 350
DMGYKCEGCK KKVSATKQFS LERAPITLCI QLKRFSMIGN KLTKTISFKP 400
RIDLSRFAAR SPAAAAQPLT YRLVSMVTHL GVSQHCGHYT AIGMTESGSY 450
YNFDDSYVRP IAMQSVCNTN AYIMFYELDL SQTTPLKSNG LRLTNGHSQV 500
AVPATVSSSS PTHTRFIGPQ LPPGGINGYS NGHATGSSNA QKTAIQFKQQ 550
QQHPQQNGLQ VGTGKFQEPP HAKSPLAGAY NKGEAFPATT ANGNKSSSSS 600
ASNSNHNKSV NQLQHQQHYL PISSEDEDSE DGATATATAT ATARPTAQLP 650
SMPKMTEDSS DKPKTPLKSS VKTNLVKSLL KTPLKSLVPY ESASEEDEPL 700
PNPRKRRSDS DSNDSGDSDP QPGHVNGHTK TNGGSLTNGN GLGKAKTILA 750
TSSSSSLASA SASAASDDED ADEEEENSKL TNGWQPQKQS QSLTQSKAPP 800
SPKTPPSPAV IKSKTGIWKV TRNDDNEDED DDDDEDEEEQ HQVVSTPSKN 850
PRNPFAKSST TPGAKRQKLL NGIAVKSQQQ PRVGNGYQSE ASTNGNVVNE 900
LLKQTHRGYG SASVLSWSGK PAELEKELVA EAREQRQHDH DDEEENEMDR 950
GRQRKVKSAT AKAYNSSTPG YNPFQEYESQ KRWHKSSNGG GSFPRYHNQN 1000
FRQNFQQRNK FKYNRFGGPG GAKFQQQRAL QRHLASGGVF NRRQPTGQQQ 1050
QQQSQQSSS 1059
Length:1,059
Mass (Da):116,372
Last modified:October 14, 2008 - v2
Checksum:iA479D84A1DBFE65D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379069 Genomic DNA. Translation: EAL29597.2.
RefSeqiXP_001353862.2. XM_001353826.2.

Genome annotation databases

EnsemblMetazoaiFBtr0275771; FBpp0274209; FBgn0078933.
GeneIDi4813226.
KEGGidpo:Dpse_GA18934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379069 Genomic DNA. Translation: EAL29597.2 .
RefSeqi XP_001353862.2. XM_001353826.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0274209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0275771 ; FBpp0274209 ; FBgn0078933 .
GeneIDi 4813226.
KEGGi dpo:Dpse_GA18934.

Organism-specific databases

FlyBasei FBgn0078933. Dpse\GA18934.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi Q2LZB1.
KOi K11855.
OrthoDBi EOG7XDBF6.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiUBP36_DROPS
AccessioniPrimary (citable) accession number: Q2LZB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 14, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi