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Q2LZ62 (POMT1_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein O-mannosyltransferase 1

EC=2.4.1.109
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Protein rotated abdomen
Gene names
Name:rt
ORF Names:GA19350
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length908 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development By similarity.

Catalytic activity

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathway

Protein modification; protein glycosylation.

Subunit structure

Interacts with tw/POMT2 By similarity. UniProtKB Q9VTK2

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity UniProtKB Q9VTK2.

Sequence similarities

Belongs to the glycosyltransferase 39 family.

Contains 3 MIR domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 908908Protein O-mannosyltransferase 1
PRO_0000307926

Regions

Transmembrane190 – 21021Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane311 – 32818Helical; Potential
Transmembrane331 – 35121Helical; Potential
Transmembrane370 – 39021Helical; Potential
Transmembrane418 – 43821Helical; Potential
Transmembrane749 – 76921Helical; Potential
Transmembrane788 – 80821Helical; Potential
Transmembrane813 – 83321Helical; Potential
Transmembrane857 – 87721Helical; Potential
Domain473 – 53462MIR 1
Domain545 – 60258MIR 2
Domain608 – 66457MIR 3
Compositional bias290 – 423134Leu-rich

Amino acid modifications

Glycosylation2651N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2LZ62 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 3D0182C4D63416C4

FASTA908102,912
        10         20         30         40         50         60 
MYNNNNDGGG GGSANGNTMQ QRRKTTTRSR SKQQQQQQCT SENVIEKNQT NGAQNERLHF 

        70         80         90        100        110        120 
RGSSKDSALS TPLLPRSRST TSAINSPSPL CCNGGLSILN CCRDVNCHLN APLRGSVESS 

       130        140        150        160        170        180 
RSRRSESRQS SLTATPTTTP KQASPSPTIS ERSRSCSGSR SRSCSCDGRL VDCHKHSAAA 

       190        200        210        220        230        240 
AAASTAAPQF TVNLSIDLFS WTLFLLAFCT RFYKLATPPH IVFDELHYGK YIAHYMRNIF 

       250        260        270        280        290        300 
FFDQHPPLGK QLIAGLVSLA GYDGNYTFSR IGAAYAPDVP IFWFRFIPAL CGSLLAPAVY 

       310        320        330        340        350        360 
RLLLEARLHR WAAALGGLLV VLDNSLLTQS RFVLMESMLL LASTLGIACL LRFQRCRLGS 

       370        380        390        400        410        420 
FQWLCNGSAA GVLLACAGAV KYIGFLALAL AGYLLCRHLW QLLYDASLTN RQLWMHALSR 

       430        440        450        460        470        480 
LLLFVGIPIA VYIGVFYVHF RTLHRAGPHD SIMTSAFQAS LEGGLASITS GQPLAVVHGS 

       490        500        510        520        530        540 
QITLRHTHGR TCWLHSHAAV YPVRYKDKRG SSHQQQVTCY SFKDVNNWWI VKRPERDDLV 

       550        560        570        580        590        600 
VGEQPDVIQH GDVIQLVHGI TSRALNSHDV AAPMTPQCQE VSCYIDYEIK MAGELLWRVE 

       610        620        630        640        650        660 
ILNRNSEGDS WHAIKSEIRL VHESTGAALK FSGRQLPDWG FNQHEVVADR DQVHEDAIWN 

       670        680        690        700        710        720 
VEEHRYTKTQ DQRERERQLL SAEMIPTKRT KLSFWAKLLE LQTKMFWHGK HLQAHMYSSL 

       730        740        750        760        770        780 
PHEWPLMDKG IAYWLDSQSS AQIYLLGNVL IWYTASAGIL VYATLLAFYA VRRRRLCFDV 

       790        800        810        820        830        840 
SQHEWQRFLM AGDTFFVGYM MHYLPYYFVD RTLFLHNYLP AFVFKLLLLC FVVEHLDYLL 

       850        860        870        880        890        900 
RRHCSGRGVH LVRVYRLALL LWLLAVGSVF VKFLPLSYGA RKMTIEEVRR LRWKDTWDFI 


LQKNYALN 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH379069 Genomic DNA. Translation: EAL29647.2.
RefSeqXP_001353911.2. XM_001353875.2.

3D structure databases

ProteinModelPortalQ2LZ62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0275409.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0276971; FBpp0275409; FBgn0079347.
GeneID4813592.
KEGGdpo:Dpse_GA19350.

Organism-specific databases

FlyBaseFBgn0079347. Dpse\GA19350.

Phylogenomic databases

eggNOGCOG1928.
InParanoidQ2LZ62.
KOK00728.
OrthoDBEOG79KPDP.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERPTHR10050. PTHR10050. 1 hit.
PfamPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMSSF82109. SSF82109. 1 hit.
PROSITEPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOMT1_DROPS
AccessionPrimary (citable) accession number: Q2LZ62
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase