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Q2LZ62

- POMT1_DROPS

UniProt

Q2LZ62 - POMT1_DROPS

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Protein

Protein O-mannosyltransferase 1

Gene

rt

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.By similarity

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.Curated

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. lipid glycosylation Source: UniProtKB
  2. muscle organ development Source: UniProtKB
  3. protein O-linked mannosylation Source: GOC
  4. specification of segmental identity, abdomen Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-mannosyltransferase 1 (EC:2.4.1.109)
Alternative name(s):
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Protein rotated abdomen
Gene namesi
Name:rtBy similarity
ORF Names:GA19350
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0079347. Dpse\GA19350.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 32818HelicalSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Transmembranei749 – 76921HelicalSequence AnalysisAdd
BLAST
Transmembranei788 – 80821HelicalSequence AnalysisAdd
BLAST
Transmembranei813 – 83321HelicalSequence AnalysisAdd
BLAST
Transmembranei857 – 87721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 908908Protein O-mannosyltransferase 1PRO_0000307926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with tw/POMT2.By similarity

Protein-protein interaction databases

STRINGi7237.FBpp0275409.

Structurei

3D structure databases

ProteinModelPortaliQ2LZ62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini473 – 53462MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini545 – 60258MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini608 – 66457MIR 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 423134Leu-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Sequence Analysis
Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
InParanoidiQ2LZ62.
KOiK00728.
OrthoDBiEOG79KPDP.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LZ62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYNNNNDGGG GGSANGNTMQ QRRKTTTRSR SKQQQQQQCT SENVIEKNQT
60 70 80 90 100
NGAQNERLHF RGSSKDSALS TPLLPRSRST TSAINSPSPL CCNGGLSILN
110 120 130 140 150
CCRDVNCHLN APLRGSVESS RSRRSESRQS SLTATPTTTP KQASPSPTIS
160 170 180 190 200
ERSRSCSGSR SRSCSCDGRL VDCHKHSAAA AAASTAAPQF TVNLSIDLFS
210 220 230 240 250
WTLFLLAFCT RFYKLATPPH IVFDELHYGK YIAHYMRNIF FFDQHPPLGK
260 270 280 290 300
QLIAGLVSLA GYDGNYTFSR IGAAYAPDVP IFWFRFIPAL CGSLLAPAVY
310 320 330 340 350
RLLLEARLHR WAAALGGLLV VLDNSLLTQS RFVLMESMLL LASTLGIACL
360 370 380 390 400
LRFQRCRLGS FQWLCNGSAA GVLLACAGAV KYIGFLALAL AGYLLCRHLW
410 420 430 440 450
QLLYDASLTN RQLWMHALSR LLLFVGIPIA VYIGVFYVHF RTLHRAGPHD
460 470 480 490 500
SIMTSAFQAS LEGGLASITS GQPLAVVHGS QITLRHTHGR TCWLHSHAAV
510 520 530 540 550
YPVRYKDKRG SSHQQQVTCY SFKDVNNWWI VKRPERDDLV VGEQPDVIQH
560 570 580 590 600
GDVIQLVHGI TSRALNSHDV AAPMTPQCQE VSCYIDYEIK MAGELLWRVE
610 620 630 640 650
ILNRNSEGDS WHAIKSEIRL VHESTGAALK FSGRQLPDWG FNQHEVVADR
660 670 680 690 700
DQVHEDAIWN VEEHRYTKTQ DQRERERQLL SAEMIPTKRT KLSFWAKLLE
710 720 730 740 750
LQTKMFWHGK HLQAHMYSSL PHEWPLMDKG IAYWLDSQSS AQIYLLGNVL
760 770 780 790 800
IWYTASAGIL VYATLLAFYA VRRRRLCFDV SQHEWQRFLM AGDTFFVGYM
810 820 830 840 850
MHYLPYYFVD RTLFLHNYLP AFVFKLLLLC FVVEHLDYLL RRHCSGRGVH
860 870 880 890 900
LVRVYRLALL LWLLAVGSVF VKFLPLSYGA RKMTIEEVRR LRWKDTWDFI

LQKNYALN
Length:908
Mass (Da):102,912
Last modified:October 23, 2007 - v2
Checksum:i3D0182C4D63416C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379069 Genomic DNA. Translation: EAL29647.2.
RefSeqiXP_001353911.2. XM_001353875.2.

Genome annotation databases

EnsemblMetazoaiFBtr0276971; FBpp0275409; FBgn0079347.
GeneIDi4813592.
KEGGidpo:Dpse_GA19350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379069 Genomic DNA. Translation: EAL29647.2 .
RefSeqi XP_001353911.2. XM_001353875.2.

3D structure databases

ProteinModelPortali Q2LZ62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0275409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0276971 ; FBpp0275409 ; FBgn0079347 .
GeneIDi 4813592.
KEGGi dpo:Dpse_GA19350.

Organism-specific databases

FlyBasei FBgn0079347. Dpse\GA19350.

Phylogenomic databases

eggNOGi COG1928.
InParanoidi Q2LZ62.
KOi K00728.
OrthoDBi EOG79KPDP.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

ChiTaRSi rt. fly.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiPOMT1_DROPS
AccessioniPrimary (citable) accession number: Q2LZ62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3