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Q2LZ62

- POMT1_DROPS

UniProt

Q2LZ62 - POMT1_DROPS

Protein

Protein O-mannosyltransferase 1

Gene

rt

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.By similarity

    Catalytic activityi

    Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.Curated

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. lipid glycosylation Source: UniProtKB
    2. muscle organ development Source: UniProtKB
    3. protein O-linked mannosylation Source: GOC
    4. specification of segmental identity, abdomen Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein O-mannosyltransferase 1 (EC:2.4.1.109)
    Alternative name(s):
    Dolichyl-phosphate-mannose--protein mannosyltransferase 1
    Protein rotated abdomen
    Gene namesi
    Name:rtBy similarity
    ORF Names:GA19350
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0079347. Dpse\GA19350.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 908908Protein O-mannosyltransferase 1PRO_0000307926Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with tw/POMT2.By similarity

    Protein-protein interaction databases

    STRINGi7237.FBpp0275409.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LZ62.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 32818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei749 – 76921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei788 – 80821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei813 – 83321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei857 – 87721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini473 – 53462MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini545 – 60258MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini608 – 66457MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi290 – 423134Leu-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 39 family.Sequence Analysis
    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1928.
    InParanoidiQ2LZ62.
    KOiK00728.
    OrthoDBiEOG79KPDP.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LZ62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNNNNDGGG GGSANGNTMQ QRRKTTTRSR SKQQQQQQCT SENVIEKNQT    50
    NGAQNERLHF RGSSKDSALS TPLLPRSRST TSAINSPSPL CCNGGLSILN 100
    CCRDVNCHLN APLRGSVESS RSRRSESRQS SLTATPTTTP KQASPSPTIS 150
    ERSRSCSGSR SRSCSCDGRL VDCHKHSAAA AAASTAAPQF TVNLSIDLFS 200
    WTLFLLAFCT RFYKLATPPH IVFDELHYGK YIAHYMRNIF FFDQHPPLGK 250
    QLIAGLVSLA GYDGNYTFSR IGAAYAPDVP IFWFRFIPAL CGSLLAPAVY 300
    RLLLEARLHR WAAALGGLLV VLDNSLLTQS RFVLMESMLL LASTLGIACL 350
    LRFQRCRLGS FQWLCNGSAA GVLLACAGAV KYIGFLALAL AGYLLCRHLW 400
    QLLYDASLTN RQLWMHALSR LLLFVGIPIA VYIGVFYVHF RTLHRAGPHD 450
    SIMTSAFQAS LEGGLASITS GQPLAVVHGS QITLRHTHGR TCWLHSHAAV 500
    YPVRYKDKRG SSHQQQVTCY SFKDVNNWWI VKRPERDDLV VGEQPDVIQH 550
    GDVIQLVHGI TSRALNSHDV AAPMTPQCQE VSCYIDYEIK MAGELLWRVE 600
    ILNRNSEGDS WHAIKSEIRL VHESTGAALK FSGRQLPDWG FNQHEVVADR 650
    DQVHEDAIWN VEEHRYTKTQ DQRERERQLL SAEMIPTKRT KLSFWAKLLE 700
    LQTKMFWHGK HLQAHMYSSL PHEWPLMDKG IAYWLDSQSS AQIYLLGNVL 750
    IWYTASAGIL VYATLLAFYA VRRRRLCFDV SQHEWQRFLM AGDTFFVGYM 800
    MHYLPYYFVD RTLFLHNYLP AFVFKLLLLC FVVEHLDYLL RRHCSGRGVH 850
    LVRVYRLALL LWLLAVGSVF VKFLPLSYGA RKMTIEEVRR LRWKDTWDFI 900
    LQKNYALN 908
    Length:908
    Mass (Da):102,912
    Last modified:October 23, 2007 - v2
    Checksum:i3D0182C4D63416C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379069 Genomic DNA. Translation: EAL29647.2.
    RefSeqiXP_001353911.2. XM_001353875.2.

    Genome annotation databases

    EnsemblMetazoaiFBtr0276971; FBpp0275409; FBgn0079347.
    GeneIDi4813592.
    KEGGidpo:Dpse_GA19350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379069 Genomic DNA. Translation: EAL29647.2 .
    RefSeqi XP_001353911.2. XM_001353875.2.

    3D structure databases

    ProteinModelPortali Q2LZ62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0275409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0276971 ; FBpp0275409 ; FBgn0079347 .
    GeneIDi 4813592.
    KEGGi dpo:Dpse_GA19350.

    Organism-specific databases

    FlyBasei FBgn0079347. Dpse\GA19350.

    Phylogenomic databases

    eggNOGi COG1928.
    InParanoidi Q2LZ62.
    KOi K00728.
    OrthoDBi EOG79KPDP.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiPOMT1_DROPS
    AccessioniPrimary (citable) accession number: Q2LZ62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3