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Q2LYQ0

- Q2LYQ0_DROPS

UniProt

Q2LYQ0 - Q2LYQ0_DROPS

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Protein

Acetyl-coenzyme A synthetase

Gene

Dpse\GA21752

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-EC
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
Name:Dpse\GA21752Imported
ORF Names:Dpse_GA21752Imported, GA21752Imported
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)Imported
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0081737. Dpse\GA21752.

Interactioni

Protein-protein interaction databases

STRINGi7237.FBpp0274007.

Structurei

3D structure databases

ProteinModelPortaliQ2LYQ0.
SMRiQ2LYQ0. Positions 10-663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

InParanoidiQ2LYQ0.
KOiK01895.
OMAiAWIWYRD.
OrthoDBiEOG77T140.
PhylomeDBiQ2LYQ0.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LYQ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAEKSIYDP NPAISQNAYI SSFEEYKKFY QESLDNPAEF WSRVAKQFHW
60 70 80 90 100
ETPADQEKFL QYNFNISKGP IYIKWMEGAS TNICYNLLDR NVRNGLGDQI
110 120 130 140 150
AYYWEGNHPD DYSRGLTYRK LLEEVCRFAN VLKDHGIRKG DRVSIYMPMI
160 170 180 190 200
LELPIAMLAC ARIGAVHSIV FAGFSPDSLA ERMFDCKAKL LITADGAWRG
210 220 230 240 250
EKALYLKALC DTALEKVEEL GHSVEKCIVV SHLKRVTPCQ DNHVEEEIPW
260 270 280 290 300
TDDRDYWWHE EMEDKEPACY PEWMDAEDPL FMLYTSGSTG KPKGVLHTTA
310 320 330 340 350
GYLLYAATTF KIVFDYKPGD IYWCTADVGW ITGHTYVVYG PLANGATSVI
360 370 380 390 400
FEGTPFFPGN DRYWSVIDKY KVTQFYTAPT AIRALMKFGE GPVLKHNLSG
410 420 430 440 450
LKVLGSVGEP INPEAWLWYY RYIGKEQCSI VDTFWQTETG GHVITPLPGA
460 470 480 490 500
TPMKPGSASF PFFGVKPILL DECGIEIKGE GEGYLVFSQP WPGMMRTLYN
510 520 530 540 550
NHERFEDTYF SKFPGYYCTG DGARRDADDY LWITGRVDDM LNVSGHLMST
560 570 580 590 600
AEVESVLTEH PRVAESAVVS RPHPVKGECL YCFITPNENE PFDQKLISDL
610 620 630 640 650
KKMVRERIGP FAQPDVIQNA PGLPKTRSGK IMRRVLRKIA VNDRNVGDTS
660 670
TLADEQIVEQ LFANRPVEAK
Length:670
Mass (Da):76,116
Last modified:February 21, 2006 - v1
Checksum:iB2D5F7B8874CF491
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379069 Genomic DNA. Translation: EAL29811.1.
RefSeqiXP_001354073.1. XM_001354037.2.

Genome annotation databases

EnsemblMetazoaiFBtr0275569; FBpp0274007; FBgn0081737.
GeneIDi4813796.
KEGGidpo:Dpse_GA21752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379069 Genomic DNA. Translation: EAL29811.1 .
RefSeqi XP_001354073.1. XM_001354037.2.

3D structure databases

ProteinModelPortali Q2LYQ0.
SMRi Q2LYQ0. Positions 10-663.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0274007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0275569 ; FBpp0274007 ; FBgn0081737 .
GeneIDi 4813796.
KEGGi dpo:Dpse_GA21752.

Organism-specific databases

FlyBasei FBgn0081737. Dpse\GA21752.

Phylogenomic databases

InParanoidi Q2LYQ0.
KOi K01895.
OMAi AWIWYRD.
OrthoDBi EOG77T140.
PhylomeDBi Q2LYQ0.

Family and domain databases

InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94Imported.
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25Imported.

Entry informationi

Entry nameiQ2LYQ0_DROPS
AccessioniPrimary (citable) accession number: Q2LYQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3