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Q2LYQ0

- Q2LYQ0_DROPS

UniProt

Q2LYQ0 - Q2LYQ0_DROPS

Protein

Acetyl-coenzyme A synthetase

Gene

Dpse\GA21752

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

    GO - Molecular functioni

    1. acetate-CoA ligase activity Source: UniProtKB-EC
    2. AMP binding Source: InterPro

    GO - Biological processi

    1. acetyl-CoA biosynthetic process from acetate Source: InterPro

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
    Gene namesi
    Name:Dpse\GA21752Imported
    ORF Names:Dpse_GA21752Imported, GA21752Imported
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)Imported
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0081737. Dpse\GA21752.

    Interactioni

    Protein-protein interaction databases

    STRINGi7237.FBpp0274007.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LYQ0.
    SMRiQ2LYQ0. Positions 10-663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

    Phylogenomic databases

    InParanoidiQ2LYQ0.
    KOiK01895.
    OMAiAWIWYRD.
    OrthoDBiEOG77T140.
    PhylomeDBiQ2LYQ0.

    Family and domain databases

    InterProiIPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LYQ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAEKSIYDP NPAISQNAYI SSFEEYKKFY QESLDNPAEF WSRVAKQFHW    50
    ETPADQEKFL QYNFNISKGP IYIKWMEGAS TNICYNLLDR NVRNGLGDQI 100
    AYYWEGNHPD DYSRGLTYRK LLEEVCRFAN VLKDHGIRKG DRVSIYMPMI 150
    LELPIAMLAC ARIGAVHSIV FAGFSPDSLA ERMFDCKAKL LITADGAWRG 200
    EKALYLKALC DTALEKVEEL GHSVEKCIVV SHLKRVTPCQ DNHVEEEIPW 250
    TDDRDYWWHE EMEDKEPACY PEWMDAEDPL FMLYTSGSTG KPKGVLHTTA 300
    GYLLYAATTF KIVFDYKPGD IYWCTADVGW ITGHTYVVYG PLANGATSVI 350
    FEGTPFFPGN DRYWSVIDKY KVTQFYTAPT AIRALMKFGE GPVLKHNLSG 400
    LKVLGSVGEP INPEAWLWYY RYIGKEQCSI VDTFWQTETG GHVITPLPGA 450
    TPMKPGSASF PFFGVKPILL DECGIEIKGE GEGYLVFSQP WPGMMRTLYN 500
    NHERFEDTYF SKFPGYYCTG DGARRDADDY LWITGRVDDM LNVSGHLMST 550
    AEVESVLTEH PRVAESAVVS RPHPVKGECL YCFITPNENE PFDQKLISDL 600
    KKMVRERIGP FAQPDVIQNA PGLPKTRSGK IMRRVLRKIA VNDRNVGDTS 650
    TLADEQIVEQ LFANRPVEAK 670
    Length:670
    Mass (Da):76,116
    Last modified:February 21, 2006 - v1
    Checksum:iB2D5F7B8874CF491
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379069 Genomic DNA. Translation: EAL29811.1.
    RefSeqiXP_001354073.1. XM_001354037.2.

    Genome annotation databases

    EnsemblMetazoaiFBtr0275569; FBpp0274007; FBgn0081737.
    GeneIDi4813796.
    KEGGidpo:Dpse_GA21752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379069 Genomic DNA. Translation: EAL29811.1 .
    RefSeqi XP_001354073.1. XM_001354037.2.

    3D structure databases

    ProteinModelPortali Q2LYQ0.
    SMRi Q2LYQ0. Positions 10-663.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0274007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0275569 ; FBpp0274007 ; FBgn0081737 .
    GeneIDi 4813796.
    KEGGi dpo:Dpse_GA21752.

    Organism-specific databases

    FlyBasei FBgn0081737. Dpse\GA21752.

    Phylogenomic databases

    InParanoidi Q2LYQ0.
    KOi K01895.
    OMAi AWIWYRD.
    OrthoDBi EOG77T140.
    PhylomeDBi Q2LYQ0.

    Family and domain databases

    InterProi IPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94Imported.
    2. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25Imported.

    Entry informationi

    Entry nameiQ2LYQ0_DROPS
    AccessioniPrimary (citable) accession number: Q2LYQ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 21, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3