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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:SYNAS_28830
ORF Names:SYN_02394
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
Proteomesi
  • UP000001933 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei150 – 170HelicalUniRule annotationAdd BLAST21
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21
Transmembranei289 – 309HelicalUniRule annotationAdd BLAST21
Transmembranei320 – 340HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502771 – 343Undecaprenyl-diphosphataseAdd BLAST343

Interactioni

Protein-protein interaction databases

STRINGi56780.SYN_02394.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218356.
KOiK06153.
OMAiWVIYATI.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LXE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKHHLRHAL LVLSAAILLA VSCSFSAASA SASPPASEKK IAVWEAAILG
60 70 80 90 100
VVEGITEYLP ISSTGHLILA SHALGMTQFS ETRGPLGTLM VKNDAMDSYN
110 120 130 140 150
IVIQLGAILA VLGLYRKRVK QMLKGLSGAL AVLVSRRSVT ALGDSERQGL
160 170 180 190 200
KLLGLLLLAF LPAAVFGKLF HEVIETYLFG PLPVVYALVA GGVLMIGVEY
210 220 230 240 250
FFWLKDRNRL RISDVNSMFY RQALFIGMMQ VVSMWPGTSR SMITMIAGLI
260 270 280 290 300
VGLDMIAAAE FSFLLALPTL GAATLYSGYK NWHALDDSAG MLALAVGLAV
310 320 330 340
SWLTAVIAVK ALVRWLTHHG LIPFGVYRIL LAGVLLIYFW QWR
Length:343
Mass (Da):37,215
Last modified:February 21, 2006 - v1
Checksum:i8E6610133B28FDDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA. Translation: ABC78761.1.
RefSeqiWP_011418778.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC78761; ABC78761; SYN_02394.
KEGGisat:SYN_02394.
PATRICi23866651. VBISynAci70500_3104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA. Translation: ABC78761.1.
RefSeqiWP_011418778.1. NC_007759.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi56780.SYN_02394.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC78761; ABC78761; SYN_02394.
KEGGisat:SYN_02394.
PATRICi23866651. VBISynAci70500_3104.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218356.
KOiK06153.
OMAiWVIYATI.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_SYNAS
AccessioniPrimary (citable) accession number: Q2LXE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: February 21, 2006
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.