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Q2LXE8 (UPPP_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SYNAS_28830
ORF Names:SYN_02394
OrganismSyntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]
Taxonomic identifier56780 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250277

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane245 – 26521Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane320 – 34021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2LXE8 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: 8E6610133B28FDDF

FASTA34337,215
        10         20         30         40         50         60 
MKKHHLRHAL LVLSAAILLA VSCSFSAASA SASPPASEKK IAVWEAAILG VVEGITEYLP 

        70         80         90        100        110        120 
ISSTGHLILA SHALGMTQFS ETRGPLGTLM VKNDAMDSYN IVIQLGAILA VLGLYRKRVK 

       130        140        150        160        170        180 
QMLKGLSGAL AVLVSRRSVT ALGDSERQGL KLLGLLLLAF LPAAVFGKLF HEVIETYLFG 

       190        200        210        220        230        240 
PLPVVYALVA GGVLMIGVEY FFWLKDRNRL RISDVNSMFY RQALFIGMMQ VVSMWPGTSR 

       250        260        270        280        290        300 
SMITMIAGLI VGLDMIAAAE FSFLLALPTL GAATLYSGYK NWHALDDSAG MLALAVGLAV 

       310        320        330        340 
SWLTAVIAVK ALVRWLTHHG LIPFGVYRIL LAGVLLIYFW QWR 

« Hide

References

[1]"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000252 Genomic DNA. Translation: ABC78761.1.
RefSeqYP_462930.1. NC_007759.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING56780.SYN_02394.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC78761; ABC78761; SYN_02394.
GeneID3882491.
KEGGsat:SYN_02394.
PATRIC23866651. VBISynAci70500_3104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAVIYFRNE.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSACI56780:GHXT-2932-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_SYNAS
AccessionPrimary (citable) accession number: Q2LXE8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families