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Q2LWU1 (TRUB_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA pseudouridine synthase B

EC=5.4.99.25
Alternative name(s):
tRNA pseudouridine(55) synthase
Short name=Psi55 synthase
tRNA pseudouridylate synthase
tRNA-uridine isomerase
Gene names
Name:truB
Ordered Locus Names:SYNAS_26720
ORF Names:SYN_01783
OrganismSyntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]
Taxonomic identifier56780 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs By similarity. HAMAP-Rule MF_01080

Catalytic activity

tRNA uridine55 = tRNA pseudouridine55. HAMAP-Rule MF_01080

Sequence similarities

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA pseudouridine synthesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312tRNA pseudouridine synthase B HAMAP-Rule MF_01080
PRO_1000084704

Sites

Active site381Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2LWU1 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: 11DDAA1854061950

FASTA31234,305
        10         20         30         40         50         60 
MDGILILDKS PGKTSQKVVQ EVKRILGVRK AGHAGTLDPL ATGVLPLCLN EATKLVQFLS 

        70         80         90        100        110        120 
LDDKEYRATM LLGVTTETMD IEGRITDRRE PEVDEVRIRE ALQFFTGPIS QEPPRYSAVK 

       130        140        150        160        170        180 
FKGRPLYSWA RKGVDIALPP RTVQVYSSIL EEIALPYVTF RVACSKGTYI RTLCADLGER 

       190        200        210        220        230        240 
LGCGACMSVL RRLRCGCFTL ETAVSLEDIA DGKGRETLLS RVIPLSDGLR NVAAIEISEE 

       250        260        270        280        290        300 
LSGRIRDGFQ PDGSTLREYH IPSLADGDMV KFLTSSGGLV AVARFLYASD QLAVSDMGQP 

       310 
AVRILRVFHD RA 

« Hide

References

[1]"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000252 Genomic DNA. Translation: ABC78551.1.
RefSeqYP_462719.1. NC_007759.1.

3D structure databases

ProteinModelPortalQ2LWU1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING56780.SYN_01783.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC78551; ABC78551; SYN_01783.
GeneID3882721.
KEGGsat:SYN_01783.
PATRIC23866222. VBISynAci70500_2892.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0130.
HOGENOMHOG000231225.
KOK03177.
OMAQKVKRIF.
OrthoDBEOG6358D3.

Enzyme and pathway databases

BioCycSACI56780:GHXT-2722-MONOMER.

Family and domain databases

HAMAPMF_01080. TruB_bact.
InterProIPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR014780. tRNA_psdUridine_synth_TruB.
[Graphical view]
PANTHERPTHR13767. PTHR13767. 1 hit.
PfamPF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00431. TruB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRUB_SYNAS
AccessionPrimary (citable) accession number: Q2LWU1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 21, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families