ID   Q2LW85_SYNAS            Unreviewed;       688 AA.
AC   Q2LW85;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:ABC78346.1};
GN   ORFNames=SYN_01236 {ECO:0000313|EMBL:ABC78346.1};
OS   Syntrophus aciditrophicus (strain SB).
OC   Bacteria; Thermodesulfobacteriota; Syntrophia; Syntrophales; Syntrophaceae;
OC   Syntrophus.
OX   NCBI_TaxID=56780 {ECO:0000313|EMBL:ABC78346.1, ECO:0000313|Proteomes:UP000001933};
RN   [1] {ECO:0000313|EMBL:ABC78346.1, ECO:0000313|Proteomes:UP000001933}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB {ECO:0000313|EMBL:ABC78346.1,
RC   ECO:0000313|Proteomes:UP000001933};
RX   PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA   McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA   Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA   Campbell J.W., Gunsalus R.P.;
RT   "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT   of microbial growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000252; ABC78346.1; -; Genomic_DNA.
DR   RefSeq; WP_011418365.1; NC_007759.1.
DR   AlphaFoldDB; Q2LW85; -.
DR   STRING; 56780.SYN_01236; -.
DR   KEGG; sat:SYN_01236; -.
DR   eggNOG; COG0840; Bacteria.
DR   eggNOG; COG2972; Bacteria.
DR   HOGENOM; CLU_000445_107_19_7; -.
DR   InParanoid; Q2LW85; -.
DR   OrthoDB; 2489132at2; -.
DR   Proteomes; UP000001933; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   CDD; cd12914; PDC1_DGC_like; 1.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001933};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          319..372
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          416..652
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
SQ   SEQUENCE   688 AA;  73665 MW;  AA987529C3411AF6 CRC64;
     MKMKLGTKLL TGGLLVVAIP LIVIGIASIY IAKDSISTIA HDEMANVSNA LASNIDLGLT
     EEMRRSQDIS FSNSAVAAAE KVAKAGKEDS QSEIALVQRE LTRIREAAGD RYETIVLFGT
     DGIVFADAVQ GRDHGIDASD RDYFKKAMQG KCNLSDVVRS KATGNLICMA ACPIFSEKSR
     KIVGVAGCAI NVSFLTELVD KVKIGQTGYS VLLNREGVVL AHPNKENILT LNYKSLKGKG
     IDLLGKKIAS QESGMVEYEF QGVDKVGAFT NIKTTGWTAF TSIPRDELFK PAVFTGNLIA
     VVGFISLLLA AAFFYFFSRS LTRPLEKVVS AAEQIAEGDL SVQISDENRQ DEIGMLARAF
     MKMTQSLQEK AGVLQQIAAG NLTVEMKTPS DRDVMGKAFA AMISALRAEM QSIREAVNVI
     ASSATQISAS TTELASAASQ TASAVSETTS TVEEVKQTAH LSTQKATHVF DSAQKATEVS
     QQGRKAIDLA VEGMNFIRTQ TDSISESIVK LSERSQAIGE IIATVNDIAD QSNLLAVNAA
     IEAAKAGDQG KGFAVVAQEV RNLAEQSKQA TSQVRTILNE IQKAVGEAVM STEQEIKAVE
     AGMRQTSEAG NSFRRLSDTI EESAQAATQI TASSQQQLVG MDQVVLAITN INQASSQNVA
     GAKQVETAAQ NLHDLGQQLK QLIDRYRL
//