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Q2LW66

- Q2LW66_SYNAS

UniProt

Q2LW66 - Q2LW66_SYNAS

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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Syntrophus aciditrophicus (strain SB)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei155 – 1551Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei158 – 1581N2-acetyl-L-ornithineUniRule annotation
Binding sitei320 – 3201N2-acetyl-L-ornithineUniRule annotation
Binding sitei321 – 3211Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSACI56780:GHXT-2497-MONOMER.
UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
ORF Names:SYN_01215Imported
OrganismiSyntrophus aciditrophicus (strain SB)Imported
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi56780.SYN_01215.

Structurei

3D structure databases

ProteinModelPortaliQ2LW66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni263 – 2664Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0160.
HOGENOMiHOG000020206.
KOiK00823.
OMAiCALANDD.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LW66 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMKENGNSC SGTRMSKEGE TMREDLVTRT QRLLAPSLVI HSDIVVKRGH
60 70 80 90 100
GVYLESVDGK RYLDFTSGLA VANVGHSHPK IVEAIKKQAE ELVHAGCMFY
110 120 130 140 150
YEPLAEYPER LKEVTPPGLD RFFFSNSGAE AIEGALKLAR YFTGRQGILA
160 170 180 190 200
FSGAFHGRTY GALSLTASNA KYRNRYAPLL PSVYHAPYPY CYRCDIGREP
210 220 230 240 250
ETCSLECFGH VETLLNRLIA PEEIACAVIE PMLGEGGYVV PPARYLKKLR
260 270 280 290 300
KLCDREGILL IFDEVQSGMG RTGRWFASEH FGIVPDIMTL AKGIANGMPL
310 320 330 340 350
SAVVSSGRIM DGWAPGTHGT TFGGNPVSLC AAAATLRVIE EERLLENAAV
360 370 380 390 400
VGSKALERLE SMKDRHPVIG DVRGRGLMIG VEFVREGKEP DRATVEKIMK
410 420 430 440
TCLDRGLLLV ECGGDKNILR LIPPLVITRE EMDHGLDILE EAIVKSA
Length:447
Mass (Da):49,113
Last modified:February 21, 2006 - v1
Checksum:i6C12244006FB7173
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC78326.1.
RefSeqiYP_462494.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC78326; ABC78326; SYN_01215.
GeneIDi3883321.
KEGGisat:SYN_01215.
PATRICi23865726. VBISynAci70500_2644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC78326.1 .
RefSeqi YP_462494.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LW66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_01215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC78326 ; ABC78326 ; SYN_01215 .
GeneIDi 3883321.
KEGGi sat:SYN_01215.
PATRICi 23865726. VBISynAci70500_2644.

Phylogenomic databases

eggNOGi COG0160.
HOGENOMi HOG000020206.
KOi K00823.
OMAi CALANDD.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00109 .
BioCyci SACI56780:GHXT-2497-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBImported.

Entry informationi

Entry nameiQ2LW66_SYNAS
AccessioniPrimary (citable) accession number: Q2LW66
Entry historyi
Integrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3