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Q2LVL8

- LPXB_SYNAS

UniProt

Q2LVL8 - LPXB_SYNAS

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, SYNAS_22450, SYN_01565
Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSACI56780:GHXT-2294-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:SYNAS_22450
ORF Names:SYN_01565
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255228Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi56780.SYN_01565.

Structurei

3D structure databases

ProteinModelPortaliQ2LVL8.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2LVL8-1 [UniParc]FASTAAdd to Basket

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MNSKLVLIVA GEASGDLHGA SLVGAMVKRE PGIRFYGIGG VNLKTAGVDL    50
WADAADMAVV GLTEVASKLR GILTVMHRLK KSMQLLKPDL VILIDYPDFN 100
LPLARSAKKN GIPVFYYISP QVWAWRKGRL RTISGLVDRM AVILPFEEPL 150
YRQAGVDVSF VGHPLLDVVQ ATSSRDETLR MFGLREDVTT VALLPGSRKG 200
EVTRLLPVML KAARILTENI CPVQFLLPMA NTLDETWMKD QIAKADPPGV 250
RLIRGATYDA VAAADAAVVV SGTATLETAL LGTPLIVIYK VSALSYLIGR 300
MLISVDHIGL VNIVAGKTVA PELIQGAANP ERIAAEILAI LGQPDRRKAI 350
QEELSHLRDK LGLPGAAERA AVMALTLIKK SDC 383
Length:383
Mass (Da):41,277
Last modified:February 21, 2006 - v1
Checksum:i6086447ADAB7F983
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC78124.1.
RefSeqiYP_462292.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC78124; ABC78124; SYN_01565.
GeneIDi3883758.
KEGGisat:SYN_01565.
PATRICi23865278. VBISynAci70500_2421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC78124.1 .
RefSeqi YP_462292.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LVL8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_01565.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC78124 ; ABC78124 ; SYN_01565 .
GeneIDi 3883758.
KEGGi sat:SYN_01565.
PATRICi 23865278. VBISynAci70500_2421.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SACI56780:GHXT-2294-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB.

Entry informationi

Entry nameiLPXB_SYNAS
AccessioniPrimary (citable) accession number: Q2LVL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3