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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi384 – 3918ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI56780:GHXT-2293-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:SYNAS_22440
ORF Names:SYN_01564
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
Proteomesi
  • UP000001933 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalUniRule annotationAdd
BLAST
Transmembranei77 – 9721HelicalUniRule annotationAdd
BLAST
Transmembranei150 – 17021HelicalUniRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalUniRule annotationAdd
BLAST
Transmembranei263 – 28321HelicalUniRule annotationAdd
BLAST
Transmembranei286 – 30621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Lipid A export ATP-binding/permease protein MsbAPRO_0000271660Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi56780.SYN_01564.

Structurei

3D structure databases

ProteinModelPortaliQ2LVL0.
SMRiQ2LVL0. Positions 351-587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 318284ABC transmembrane type-1UniRule annotationAdd
BLAST
Domaini352 – 585234ABC transporterUniRule annotationAdd
BLAST

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation
Contains 1 ABC transmembrane type-1 domain.UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiRSWWAGH.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LVL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNRGCKPR RFEGNQRMDI FKRLLKLARP HAPRFAVAMV CMLIAGALTS
60 70 80 90 100
SLAFLVKPAL DDIFLDRNAE MLKWIPLAII LIYLVKGGCS YFQAILMSFI
110 120 130 140 150
GQRIVADLRN RLYEQIQKQS LSFFSKNPTG VLMSRITNDV NSIQGTVSDA
160 170 180 190 200
VTSLMKDSFT LICLVFVIFY RDWQLAIIAM IVFPLTIYPI AKFGQKMRSV
210 220 230 240 250
ATRTQVTMGS LTTLLQETIS GTRIVRAFCM EAHENQRFAR ENEKLMHLAL
260 270 280 290 300
KSVSINALSS PFMEFLGGIG IAAIIFYGGY QVIKGSSTPG TFFSFLTALI
310 320 330 340 350
MLYEPVKRLT NVNNTIQQGI AGAQRVFSII DLVPDIVDRD EAVELPRISE
360 370 380 390 400
KIEIRNISFA YDDTPVLRNI NLTIRAGEVV AFVGMSGGGK TTLVNLIPRF
410 420 430 440 450
YDVTAGQILI DGHDIRDVSL ISLRRQIGIV TQQTILFNDT VRNNIAYGSQ
460 470 480 490 500
GCSEKEIIEA ARAANAHDFI VNLPEGYDTV IGELGTKLSG GERQRISIAR
510 520 530 540 550
ALLKNAPILI LDEATSSLDT EAEMEVQEAL ERLMKGRTTL VIAHRLSTIR
560 570 580 590 600
NADRIVVLVK GEIVEEGAHE TLLARRGEYY KLHQLQFKED KVGEEVGRND

S
Length:601
Mass (Da):66,909
Last modified:February 21, 2006 - v1
Checksum:i68D656D9AEBBC23D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA. Translation: ABC78123.1.

Genome annotation databases

EnsemblBacteriaiABC78123; ABC78123; SYN_01564.
KEGGisat:SYN_01564.
PATRICi23865276. VBISynAci70500_2420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA. Translation: ABC78123.1.

3D structure databases

ProteinModelPortaliQ2LVL0.
SMRiQ2LVL0. Positions 351-587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi56780.SYN_01564.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC78123; ABC78123; SYN_01564.
KEGGisat:SYN_01564.
PATRICi23865276. VBISynAci70500_2420.

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiRSWWAGH.
OrthoDBiPOG091H00DB.

Enzyme and pathway databases

BioCyciSACI56780:GHXT-2293-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSBA_SYNAS
AccessioniPrimary (citable) accession number: Q2LVL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 21, 2006
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.