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Q2LUP0

- GCH4_SYNAS

UniProt

Q2LUP0 - GCH4_SYNAS

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, SYNAS_19170, SYN_01308
Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSACI56780:GHXT-1963-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:SYNAS_19170
ORF Names:SYN_01308
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255GTP cyclohydrolase FolE2UniRule annotationPRO_0000289528Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi56780.SYN_01308.

Structurei

3D structure databases

ProteinModelPortaliQ2LUP0.
SMRiQ2LUP0. Positions 12-255.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LUP0-1 [UniParc]FASTAAdd to Basket

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MIDIQNLEDH RKINIQKVGV KGINYPIVVL DKAKGTQHVN ASINMYVDLP    50
HHFKGTHMSR FIEVLNEFRG EINIRTFHTI LEKVRDKLKA ESAHMEITFP 100
YFIEKTAPVS GAKSLMDYIC AFSGMNAENK KDFLVGVVVP VTTVCPCSKE 150
ISCMGAHNQR SHVTVKVRFK KFFWLEDIIR LVETSASGEV YSLLKRVDEK 200
YVTEQGYANP MFVEDVVRNV AERLNENSNL TWYSVEAENF ESIHNHNAYA 250
YVEKE 255
Length:255
Mass (Da):29,293
Last modified:February 21, 2006 - v1
Checksum:i108861A3C36EA17E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77796.1.
RefSeqiYP_461964.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC77796; ABC77796; SYN_01308.
GeneIDi3882569.
KEGGisat:SYN_01308.
PATRICi23864580. VBISynAci70500_2075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77796.1 .
RefSeqi YP_461964.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LUP0.
SMRi Q2LUP0. Positions 12-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_01308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC77796 ; ABC77796 ; SYN_01308 .
GeneIDi 3882569.
KEGGi sat:SYN_01308.
PATRICi 23864580. VBISynAci70500_2075.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SACI56780:GHXT-1963-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB.

Entry informationi

Entry nameiGCH4_SYNAS
AccessioniPrimary (citable) accession number: Q2LUP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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