Q2LUA7 (DXS_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	SYNAS_17860
ORF Names:	SYN_02456

Organism

Syntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]

Taxonomic identifier

56780 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Syntrophobacterales › Syntrophaceae › Syntrophus

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 650	650	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256491

Sequences

	Sequence		Length	Mass (Da)
	Q2LUA7 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: 32CC3143E0190CFB	FASTA	650	70,930
	10 20 30 40 50 60 MFISSMNPVK KNNSGGILSR IQFPEDIRML DIGDLTLLAS DIRSAIIETV SRTGGHLASS 70 80 90 100 110 120 LGTVELTLAV HKVFDTPKDR VIWDVGHQAY AHKLITGRRD VFSTLRQKGG ISGFPKREES 130 140 150 160 170 180 PYDVFNVGHS STSISAASGI AEARDLKKER FKVVAIIGDG SMTAGLAFEG LNWSGDRKKD 190 200 210 220 230 240 LVIILNDNEM SISPNVGALS SYLNHIMTGQ TANKIRKDIR NFLKTIPSIG EQVLEFSRRA 250 260 270 280 290 300 EESLKALIVP GALFEDLGFT YVGPLEGHRL DHLIRNLEDV RNMEGPVLVH VITRKGKGYK 310 320 330 340 350 360 FAEAEPLRFH GICPFSPETG KPAAASESPV PPSYTQVFGN TIVKLARQNP RLVAITAAMC 370 380 390 400 410 420 EGTGLNAFAE EFPERFFDVG IAEQHSVTFA AGLATEGILP VVAIYSSFLQ RAYDQILHDV 430 440 450 460 470 480 CLQNLPVVFA LDRAGFVGED GPTHHGLFDL SYLRSIPNMV VMAPKDENEL QHMLHTAVAC 490 500 510 520 530 540 GKPAAVRYPR GSGVGVTMDS QPFSLELGKG EVLCEGGSLA ILAVGDPVHP ALTAAVQLRE 550 560 570 580 590 600 EGIYATVVNA RFVKPLDREL LLRIVRSFKK ILTVEENVLT GGFGSAILEF LEENDIHGIQ 610 620 630 640 650 VKRLGIRDEF AEQATQAEQR RLYGIDEQGI AAAVRSMMNM GRSSQMEACL

References

[1]

"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential." Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000252 Genomic DNA. Translation: ABC77665.1.
RefSeq	YP_461833.1. NC_007759.1.
3D structure databases
ProteinModelPortal	Q2LUA7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2LUA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3883214.
GenomeReviews	Gene locus SYNAS_17860 in contig CP000252_GR.
KEGG	sat:SYN_02456.
NMPDR	fig|56780.10.peg.1771.
PATRIC	23864294. VBISynAci70500_1934.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	RAHEFES.
PhylomeDB	Q2LUA7.
Enzyme and pathway databases
BioCyc	SACI56780:SYN_02456-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_SYNAS

Accession

Primary (citable) accession number: Q2LUA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	February 21, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program