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Q2LU82

- FTHS_SYNAS

UniProt

Q2LU82 - FTHS_SYNAS

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI56780:GHXT-1808-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SYNAS_17640
ORF Names:SYN_02008
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Formate--tetrahydrofolate ligasePRO_0000293072Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi56780.SYN_02008.

Structurei

3D structure databases

ProteinModelPortaliQ2LU82.
SMRiQ2LU82. Positions 11-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LU82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHRNSRQDT KELKPIADIA ATIGLSEDDI EAYGRYKAKV RLEAISRFHS
60 70 80 90 100
RPDASLILVS AMTPTPAGEG KTTVSIGLAQ ALARLGKATI AALREPSLGP
110 120 130 140 150
VFGMKGGATG GGLSRVHPVD DINLHFTNDF AAVESAHNLL SAIVDNSVYH
160 170 180 190 200
DNILNIDPRK VTWRRVLDMN DRFLRNIVIG LGGSVNGVPR ETGFDIVPSS
210 220 230 240 250
EIMAILCLSR SYRELKEKIR RILVGFTYDD SPVMAGDLKV EGAVTALLKY
260 270 280 290 300
ALLPNLVQTT ENVPAIIHGG PFANIAQGTS SILGTDLALR LADYVVTEAG
310 320 330 340 350
FGFDLGAEKF FDIVAPYGGL NPRIVVLVAT VRALKYHAGI AQADLDRSNP
360 370 380 390 400
RAAVLGMANL RKHYQNIDKF HVSCVIALNR FSSDTDEEIN AVVRAAENEG
410 420 430 440 450
MNIAPCDIFR LGGEGGLELA EKTLELLAGT SCGYRRLYEW NQPVEDKIFT
460 470 480 490 500
VASEIYGAVS IDYQPLARRN LDLINKYGFD KLPVCIAKTQ QSLSDNPGLL
510 520 530 540 550
GLPRDFIVTV REIRIASGAG FLIPITGEIL RMPGLSKRPA AYSIDIDDSG
560
NITGVGSPGG ISSLS
Length:565
Mass (Da):60,940
Last modified:February 21, 2006 - v1
Checksum:iB4CF77DEDE1BFDE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77643.1.
RefSeqiYP_461811.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC77643; ABC77643; SYN_02008.
GeneIDi3882768.
KEGGisat:SYN_02008.
PATRICi23864250. VBISynAci70500_1912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77643.1 .
RefSeqi YP_461811.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LU82.
SMRi Q2LU82. Positions 11-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_02008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC77643 ; ABC77643 ; SYN_02008 .
GeneIDi 3882768.
KEGGi sat:SYN_02008.
PATRICi 23864250. VBISynAci70500_1912.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SACI56780:GHXT-1808-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB.

Entry informationi

Entry nameiFTHS_SYNAS
AccessioniPrimary (citable) accession number: Q2LU82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 21, 2006
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3