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Q2LU82

- FTHS_SYNAS

UniProt

Q2LU82 - FTHS_SYNAS

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSACI56780:GHXT-1808-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SYNAS_17640
    ORF Names:SYN_02008
    OrganismiSyntrophus aciditrophicus (strain SB)
    Taxonomic identifieri56780 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
    ProteomesiUP000001933: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Formate--tetrahydrofolate ligasePRO_0000293072Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi56780.SYN_02008.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LU82.
    SMRiQ2LU82. Positions 11-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LU82-1 [UniParc]FASTAAdd to Basket

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    MTHRNSRQDT KELKPIADIA ATIGLSEDDI EAYGRYKAKV RLEAISRFHS    50
    RPDASLILVS AMTPTPAGEG KTTVSIGLAQ ALARLGKATI AALREPSLGP 100
    VFGMKGGATG GGLSRVHPVD DINLHFTNDF AAVESAHNLL SAIVDNSVYH 150
    DNILNIDPRK VTWRRVLDMN DRFLRNIVIG LGGSVNGVPR ETGFDIVPSS 200
    EIMAILCLSR SYRELKEKIR RILVGFTYDD SPVMAGDLKV EGAVTALLKY 250
    ALLPNLVQTT ENVPAIIHGG PFANIAQGTS SILGTDLALR LADYVVTEAG 300
    FGFDLGAEKF FDIVAPYGGL NPRIVVLVAT VRALKYHAGI AQADLDRSNP 350
    RAAVLGMANL RKHYQNIDKF HVSCVIALNR FSSDTDEEIN AVVRAAENEG 400
    MNIAPCDIFR LGGEGGLELA EKTLELLAGT SCGYRRLYEW NQPVEDKIFT 450
    VASEIYGAVS IDYQPLARRN LDLINKYGFD KLPVCIAKTQ QSLSDNPGLL 500
    GLPRDFIVTV REIRIASGAG FLIPITGEIL RMPGLSKRPA AYSIDIDDSG 550
    NITGVGSPGG ISSLS 565
    Length:565
    Mass (Da):60,940
    Last modified:February 21, 2006 - v1
    Checksum:iB4CF77DEDE1BFDE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000252 Genomic DNA. Translation: ABC77643.1.
    RefSeqiYP_461811.1. NC_007759.1.

    Genome annotation databases

    EnsemblBacteriaiABC77643; ABC77643; SYN_02008.
    GeneIDi3882768.
    KEGGisat:SYN_02008.
    PATRICi23864250. VBISynAci70500_1912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000252 Genomic DNA. Translation: ABC77643.1 .
    RefSeqi YP_461811.1. NC_007759.1.

    3D structure databases

    ProteinModelPortali Q2LU82.
    SMRi Q2LU82. Positions 11-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 56780.SYN_02008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC77643 ; ABC77643 ; SYN_02008 .
    GeneIDi 3882768.
    KEGGi sat:SYN_02008.
    PATRICi 23864250. VBISynAci70500_1912.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SACI56780:GHXT-1808-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
      Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB.

    Entry informationi

    Entry nameiFTHS_SYNAS
    AccessioniPrimary (citable) accession number: Q2LU82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3