Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SYNAS_17640
ORF Names:SYN_02008
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
Proteomesi
  • UP000001933 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002930721 – 565Formate--tetrahydrofolate ligaseAdd BLAST565

Interactioni

Protein-protein interaction databases

STRINGi56780.SYN_02008.

Structurei

3D structure databases

ProteinModelPortaliQ2LU82.
SMRiQ2LU82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2LU82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHRNSRQDT KELKPIADIA ATIGLSEDDI EAYGRYKAKV RLEAISRFHS
60 70 80 90 100
RPDASLILVS AMTPTPAGEG KTTVSIGLAQ ALARLGKATI AALREPSLGP
110 120 130 140 150
VFGMKGGATG GGLSRVHPVD DINLHFTNDF AAVESAHNLL SAIVDNSVYH
160 170 180 190 200
DNILNIDPRK VTWRRVLDMN DRFLRNIVIG LGGSVNGVPR ETGFDIVPSS
210 220 230 240 250
EIMAILCLSR SYRELKEKIR RILVGFTYDD SPVMAGDLKV EGAVTALLKY
260 270 280 290 300
ALLPNLVQTT ENVPAIIHGG PFANIAQGTS SILGTDLALR LADYVVTEAG
310 320 330 340 350
FGFDLGAEKF FDIVAPYGGL NPRIVVLVAT VRALKYHAGI AQADLDRSNP
360 370 380 390 400
RAAVLGMANL RKHYQNIDKF HVSCVIALNR FSSDTDEEIN AVVRAAENEG
410 420 430 440 450
MNIAPCDIFR LGGEGGLELA EKTLELLAGT SCGYRRLYEW NQPVEDKIFT
460 470 480 490 500
VASEIYGAVS IDYQPLARRN LDLINKYGFD KLPVCIAKTQ QSLSDNPGLL
510 520 530 540 550
GLPRDFIVTV REIRIASGAG FLIPITGEIL RMPGLSKRPA AYSIDIDDSG
560
NITGVGSPGG ISSLS
Length:565
Mass (Da):60,940
Last modified:February 21, 2006 - v1
Checksum:iB4CF77DEDE1BFDE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA. Translation: ABC77643.1.
RefSeqiWP_011417665.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC77643; ABC77643; SYN_02008.
KEGGisat:SYN_02008.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS_SYNAS
AccessioniPrimary (citable) accession number: Q2LU82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 21, 2006
Last modified: July 5, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families