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Q2LU82

- FTHS_SYNAS

UniProt

Q2LU82 - FTHS_SYNAS

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, SYNAS_17640, SYN_02008
Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI56780:GHXT-1808-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:SYNAS_17640
ORF Names:SYN_02008
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000293072Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi56780.SYN_02008.

Structurei

3D structure databases

ProteinModelPortaliQ2LU82.
SMRiQ2LU82. Positions 11-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LU82-1 [UniParc]FASTAAdd to Basket

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MTHRNSRQDT KELKPIADIA ATIGLSEDDI EAYGRYKAKV RLEAISRFHS    50
RPDASLILVS AMTPTPAGEG KTTVSIGLAQ ALARLGKATI AALREPSLGP 100
VFGMKGGATG GGLSRVHPVD DINLHFTNDF AAVESAHNLL SAIVDNSVYH 150
DNILNIDPRK VTWRRVLDMN DRFLRNIVIG LGGSVNGVPR ETGFDIVPSS 200
EIMAILCLSR SYRELKEKIR RILVGFTYDD SPVMAGDLKV EGAVTALLKY 250
ALLPNLVQTT ENVPAIIHGG PFANIAQGTS SILGTDLALR LADYVVTEAG 300
FGFDLGAEKF FDIVAPYGGL NPRIVVLVAT VRALKYHAGI AQADLDRSNP 350
RAAVLGMANL RKHYQNIDKF HVSCVIALNR FSSDTDEEIN AVVRAAENEG 400
MNIAPCDIFR LGGEGGLELA EKTLELLAGT SCGYRRLYEW NQPVEDKIFT 450
VASEIYGAVS IDYQPLARRN LDLINKYGFD KLPVCIAKTQ QSLSDNPGLL 500
GLPRDFIVTV REIRIASGAG FLIPITGEIL RMPGLSKRPA AYSIDIDDSG 550
NITGVGSPGG ISSLS 565
Length:565
Mass (Da):60,940
Last modified:February 21, 2006 - v1
Checksum:iB4CF77DEDE1BFDE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77643.1.
RefSeqiYP_461811.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC77643; ABC77643; SYN_02008.
GeneIDi3882768.
KEGGisat:SYN_02008.
PATRICi23864250. VBISynAci70500_1912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77643.1 .
RefSeqi YP_461811.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LU82.
SMRi Q2LU82. Positions 11-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_02008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC77643 ; ABC77643 ; SYN_02008 .
GeneIDi 3882768.
KEGGi sat:SYN_02008.
PATRICi 23864250. VBISynAci70500_1912.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SACI56780:GHXT-1808-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB.

Entry informationi

Entry nameiFTHS_SYNAS
AccessioniPrimary (citable) accession number: Q2LU82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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