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Q2LTT5

- PUR5_SYNAS

UniProt

Q2LTT5 - PUR5_SYNAS

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSACI56780:GHXT-1661-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:SYNAS_16200
    ORF Names:SYN_00889
    OrganismiSyntrophus aciditrophicus (strain SB)
    Taxonomic identifieri56780 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
    ProteomesiUP000001933: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258426Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi56780.SYN_00889.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LTT5.
    SMRiQ2LTT5. Positions 17-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2LTT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MREQSSYKDA GVDIDKANLF ISRIIPLIKM TSRKEVMKGI GGFGGLFHLD    50
    LKKIKDPVLV AATDGVGTKI KIAQMMNKHD TVGIDLVAMS VNDIIVQGAE 100
    PIFFLDYIAI GQMDVERNVK LIEGIVKGCQ EAGCALIGGE TAEMPGIYSE 150
    NEYDLAGFCI GVVENGRIID GSDIRVGDRV IGIASNGIHS NGYSLVRKVI 200
    FDKAKLNVDD TIEGIENSIG EELLRPTRIY VKPVLNLMKS FNIKGIVHIT 250
    GGGFVDNIPR IVPNQCCTVI RMNSWQIPPI FSIIQELGDI DQMEMVRVFN 300
    MGIGMILIVS EKETDDIVER LNMLGEKAYI IGSIEKADGE KSAVSFT 347
    Length:347
    Mass (Da):37,969
    Last modified:February 21, 2006 - v1
    Checksum:i8FBDCFDC28C42910
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000252 Genomic DNA. Translation: ABC77499.1.
    RefSeqiYP_461667.1. NC_007759.1.

    Genome annotation databases

    EnsemblBacteriaiABC77499; ABC77499; SYN_00889.
    GeneIDi3883059.
    KEGGisat:SYN_00889.
    PATRICi23863916. VBISynAci70500_1748.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000252 Genomic DNA. Translation: ABC77499.1 .
    RefSeqi YP_461667.1. NC_007759.1.

    3D structure databases

    ProteinModelPortali Q2LTT5.
    SMRi Q2LTT5. Positions 17-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 56780.SYN_00889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC77499 ; ABC77499 ; SYN_00889 .
    GeneIDi 3883059.
    KEGGi sat:SYN_00889.
    PATRICi 23863916. VBISynAci70500_1748.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci SACI56780:GHXT-1661-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
      Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB.

    Entry informationi

    Entry nameiPUR5_SYNAS
    AccessioniPrimary (citable) accession number: Q2LTT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3