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Q2LT97

- ASSY_SYNAS

UniProt

Q2LT97 - ASSY_SYNAS

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Protein
Argininosuccinate synthase
Gene
argG, SYNAS_14290, SYN_02157
Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei89 – 891Citrulline By similarity
Binding sitei94 – 941Citrulline By similarity
Binding sitei119 – 1191ATP; via amide nitrogen By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei129 – 1291Citrulline By similarity
Binding sitei180 – 1801Citrulline By similarity
Binding sitei189 – 1891Citrulline By similarity
Binding sitei265 – 2651Citrulline By similarity
Binding sitei277 – 2771Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI56780:GHXT-1462-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:SYNAS_14290
ORF Names:SYN_02157
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthaseUniRule annotation
PRO_0000263987Add
BLAST

Proteomic databases

PRIDEiQ2LT97.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi56780.SYN_02157.

Structurei

3D structure databases

ProteinModelPortaliQ2LT97.
SMRiQ2LT97. Positions 7-399.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LT97-1 [UniParc]FASTAAdd to Basket

« Hide

MDTGVKKVVL AYSGGLDTSV IVQWLIETYG CEVIAFAADV GQKEELEGLR    50
EKAIKTGASK IYIEDLREEF ARDFVFPALR ANAIYEGTYL LGTSLARPLI 100
AKRQVEIARA EGADAVCHGA TGKGNDQVRF ELTYMALEPN IRIISAWKDP 150
NWHFKSREDM FDYAEKHNIP LPLTREKPYS SDRNLLHISH EGAILEDPWA 200
EPPEDIFTIS LSPEAAPDKP TYVEIDFEQG NPVALDGARL SPAALMEKMN 250
DIAGANGIGR VDMVENRFVG MKSRGVYETP GGTVLWAAHR ALESLTMDRE 300
VMLMRDSLIP KYAQLAYNGF WYAPEMEALQ ALIDETQKKA TGTVRMKLYK 350
GNSIVVGRKS PYSLYSEDFA TFEKDQVYNQ MDATGFIRLN ALRLRIAAMK 400
K 401
Length:401
Mass (Da):44,906
Last modified:February 21, 2006 - v1
Checksum:iCC615D17B72F3E99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77308.1.
RefSeqiYP_461476.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC77308; ABC77308; SYN_02157.
GeneIDi3884307.
KEGGisat:SYN_02157.
PATRICi23863502. VBISynAci70500_1549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC77308.1 .
RefSeqi YP_461476.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LT97.
SMRi Q2LT97. Positions 7-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_02157.

Proteomic databases

PRIDEi Q2LT97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC77308 ; ABC77308 ; SYN_02157 .
GeneIDi 3884307.
KEGGi sat:SYN_02157.
PATRICi 23863502. VBISynAci70500_1549.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SACI56780:GHXT-1462-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB.

Entry informationi

Entry nameiASSY_SYNAS
AccessioniPrimary (citable) accession number: Q2LT97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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