Q2LST8 (HIS8_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	SYNAS_12690
ORF Names:	SYN_01517

Organism

Syntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]

Taxonomic identifier

56780 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Syntrophobacterales › Syntrophaceae › Syntrophus

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000319793
Amino acid modifications
	Modified residue	220	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2LST8 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: 3011412A4F0BA811	FASTA	361	41,437
	10 20 30 40 50 60 MNAKGESMLS RRLEALTPYV PGEQPRDRKY LKLNTNENPW PPSPRIEALL REYDPDQLRL 70 80 90 100 110 120 YPDPWSLSLR QKIARKYSVD VDNIFVGNGS DEILSFVWYA FFDGLYGKLV FPQFTYSFYP 130 140 150 160 170 180 VYCDFYEIPY RRIPLRPDFT LDLEAMIENG GEPSCGMAFP NPNAPTGIAL TLKQIEDLLN 190 200 210 220 230 240 RYPTDRVVVI DEAYIDFGGE SAVGLIDRYA NLLVARTFSK SFSLAGLRLG YALGSPELIR 250 260 270 280 290 300 ALFVTKDSFN SYTVGRLTQT IGEIAIEDEA WFAEKIARII EARDFFSEEL KGQGWQVLPS 310 320 330 340 350 360 KANFVFVRKP GLTGQTIYET LKERGILVRY FNVEGIRDFV RVTIGKREDM ARLLEELKRL F

References

[1]

"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential." Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000252 Genomic DNA. Translation: ABC77148.1.
RefSeq	YP_461316.1. NC_007759.1.
3D structure databases
HSSP	HSSP built from PDB template 2F8J based on UniProtKB Q9X0D0.
ProteinModelPortal	Q2LST8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2LST8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3883777.
GenomeReviews	Gene locus SYNAS_12690 in contig CP000252_GR.
KEGG	sat:SYN_01517.
NMPDR	fig|56780.10.peg.1254.
PATRIC	23863147. VBISynAci70500_1375.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	ADYDRPC.
PhylomeDB	Q2LST8.
ProtClustDB	PRK05387.
Enzyme and pathway databases
BioCyc	SACI56780:SYN_01517-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_SYNAS

Accession

Primary (citable) accession number: Q2LST8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 21, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program