ID   Q2LSB8_SYNAS            Unreviewed;       334 AA.
AC   Q2LSB8;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Adenylate and guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:ABC76981.1};
GN   ORFNames=SYN_01363 {ECO:0000313|EMBL:ABC76981.1};
OS   Syntrophus aciditrophicus (strain SB).
OC   Bacteria; Thermodesulfobacteriota; Syntrophia; Syntrophales; Syntrophaceae;
OC   Syntrophus.
OX   NCBI_TaxID=56780 {ECO:0000313|EMBL:ABC76981.1, ECO:0000313|Proteomes:UP000001933};
RN   [1] {ECO:0000313|EMBL:ABC76981.1, ECO:0000313|Proteomes:UP000001933}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB {ECO:0000313|EMBL:ABC76981.1,
RC   ECO:0000313|Proteomes:UP000001933};
RX   PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA   McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA   Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA   Campbell J.W., Gunsalus R.P.;
RT   "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT   of microbial growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
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DR   EMBL; CP000252; ABC76981.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2LSB8; -.
DR   STRING; 56780.SYN_01363; -.
DR   KEGG; sat:SYN_01363; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2204; Bacteria.
DR   HOGENOM; CLU_000445_110_0_7; -.
DR   InParanoid; Q2LSB8; -.
DR   Proteomes; UP000001933; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR47455; ADENYLYL CYCLASE BETA; 1.
DR   PANTHER; PTHR47455:SF1; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001933}.
FT   DOMAIN          5..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          153..284
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   MOD_RES         56
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   334 AA;  37505 MW;  866D41841553D3C7 CRC64;
     MKMNYLMVVD DEEGVRRSLR KVLAKDGYEV ITAETGEEAL KIVADRKHDL ETVISDFKMP
     GMDGLQTLVE IGRMNSEITR IMLTGYATME SAIAAVNAGI DGFLTKPFEN IEIRAKVREY
     NIKKRLKSFV SVQILNELQK GNRTIAPRRQ KVSVLFSDIR GFSEIAEKMS AQELADMMND
     NYFEPLDNIV YECDGTLDKH IGDSIMGVFG SPLSHDDDSY RAVSCAIRMK ETMKAVNENL
     PGNRYFNIGI GISTGEAMAG IFGSSHKKEY TVFGPTVNLA SRLEKLAQEN QILICEETYQ
     QVRDLVSAEP VYSSTEIKGI ERKINIYSVI DHIK
//