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Q2LRD0 (G6PI_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:SYNAS_07620
ORF Names:SYN_02950
OrganismSyntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]
Taxonomic identifier56780 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000252659

Sites

Active site3561Proton donor By similarity
Active site3871 By similarity
Active site5071 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2LRD0 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: 5E29E4684DAE93A9

FASTA54660,934
        10         20         30         40         50         60 
MTASKKLTGC QAWKALAAHR RNWKLHLRDL FAGDPGRGER MTAEAVGLFL DYSKNFVTDE 

        70         80         90        100        110        120 
TLKLLLRLAE ETGLRGRIEA LFRGEKINLT ENRAALHVAL RSPKGTSIVV DGENVVPQVH 

       130        140        150        160        170        180 
DVLDRMAAFA VQVRSGSWKG HSGKGIRNVV NIGIGGSDLG PVMAYEALKY YSDRSLTFRF 

       190        200        210        220        230        240 
VSNIDGTDFA EAVQDLDAAE TLFIVASKTF TTLETMTNAS TARAWLLQGF KGDEKAVAKH 

       250        260        270        280        290        300 
FVAVSTNTAE VAKFGIDTAN MFGFWNWVGG RYSMDSAIGL STMLAIGPDN FRDMLAGFHA 

       310        320        330        340        350        360 
MDVHFRTAPF GVNLPVLMGL LTIWYNNFFA AETVAVLPYE QYLKRFPAYL QQLTMESNGK 

       370        380        390        400        410        420 
RVTLDGMEVD YQTSPIYWGE PGTNGQHSFY QLIHQGTKLI PCDFIAFVEP LHPLGRHHDL 

       430        440        450        460        470        480 
LMANVFAQAE ALAFGRTLEE VTSEGIPAWL APHKVFEGNR PSNTILAQRL TPETLGKLVA 

       490        500        510        520        530        540 
LYEHSVFTQS AIWNINPFDQ WGVELGKVLA QRVITELESR EEPELGHDSS TNAMIRRYRK 


FRERME 

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References

[1]"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000252 Genomic DNA. Translation: ABC76641.1.
RefSeqYP_460809.1. NC_007759.1.

3D structure databases

ProteinModelPortalQ2LRD0.
SMRQ2LRD0. Positions 6-544.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING56780.SYN_02950.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC76641; ABC76641; SYN_02950.
GeneID3885170.
KEGGsat:SYN_02950.
PATRIC23862031. VBISynAci70500_0826.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMAMIALTHY.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycSACI56780:GHXT-783-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_SYNAS
AccessionPrimary (citable) accession number: Q2LRD0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 21, 2006
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways