ID UVRC_SYNAS Reviewed; 618 AA. AC Q2LR71; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 21-FEB-2006, sequence version 1. DT 27-MAR-2024, entry version 96. DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203}; DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203}; DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203}; GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; GN OrderedLocusNames=SYNAS_07050; ORFNames=SYN_01348; OS Syntrophus aciditrophicus (strain SB). OC Bacteria; Thermodesulfobacteriota; Syntrophia; Syntrophales; Syntrophaceae; OC Syntrophus. OX NCBI_TaxID=56780; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SB; RX PubMed=17442750; DOI=10.1073/pnas.0610456104; RA McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S., RA Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A., RA Campbell J.W., Gunsalus R.P.; RT "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit RT of microbial growth."; RL Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007). CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the CC lesion. The N-terminal half is responsible for the 3' incision and the CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP- CC Rule:MF_00203}. CC -!- SUBUNIT: Interacts with UvrB in an incision complex. CC {ECO:0000255|HAMAP-Rule:MF_00203}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}. CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP- CC Rule:MF_00203}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000252; ABC76584.1; -; Genomic_DNA. DR RefSeq; WP_011416618.1; NC_007759.1. DR AlphaFoldDB; Q2LR71; -. DR SMR; Q2LR71; -. DR STRING; 56780.SYN_01348; -. DR KEGG; sat:SYN_01348; -. DR eggNOG; COG0322; Bacteria. DR HOGENOM; CLU_014841_3_2_7; -. DR InParanoid; Q2LR71; -. DR OrthoDB; 9804933at2; -. DR Proteomes; UP000001933; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule. DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule. DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule. DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1. DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1. DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1. DR Gene3D; 4.10.860.10; UVR domain; 1. DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1. DR HAMAP; MF_00203; UvrC; 1. DR InterPro; IPR041663; DisA/LigA_HHH. DR InterPro; IPR000305; GIY-YIG_endonuc. DR InterPro; IPR035901; GIY-YIG_endonuc_sf. DR InterPro; IPR047296; GIY-YIG_UvrC_Cho. DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif. DR InterPro; IPR010994; RuvA_2-like. DR InterPro; IPR001943; UVR_dom. DR InterPro; IPR036876; UVR_dom_sf. DR InterPro; IPR004791; UvrC. DR InterPro; IPR001162; UvrC_RNase_H_dom. DR InterPro; IPR038476; UvrC_RNase_H_dom_sf. DR NCBIfam; TIGR00194; uvrC; 1. DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1. DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1. DR Pfam; PF01541; GIY-YIG; 1. DR Pfam; PF12826; HHH_2; 1. DR Pfam; PF02151; UVR; 1. DR Pfam; PF08459; UvrC_RNaseH_dom; 1. DR SMART; SM00465; GIYc; 1. DR SMART; SM00278; HhH1; 2. DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1. DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1. DR SUPFAM; SSF47781; RuvA domain 2-like; 1. DR PROSITE; PS50164; GIY_YIG; 1. DR PROSITE; PS50151; UVR; 1. DR PROSITE; PS50165; UVRC; 1. PE 3: Inferred from homology; KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease; KW Reference proteome; SOS response. FT CHAIN 1..618 FT /note="UvrABC system protein C" FT /id="PRO_0000264969" FT DOMAIN 15..93 FT /note="GIY-YIG" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203" FT DOMAIN 203..238 FT /note="UVR" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203" SQ SEQUENCE 618 AA; 71119 MW; D90A769D1192C88D CRC64; MNRQQLEGRI DIAPRTPGVY LMKDAAGKIL YVGKAKNLKS RTRAYFSGTD SRAMIPFLVS RIHDIEFILT ETEKEALILE NNLIKEHHPR YNICFRDDKA YFNIRADLNE PFPRFQLVRR PRKDGAKYFG PYPSSASARE TLQFLQSIFP LRTCRDAELK SRTRPCLEYQ IKRCLAPCVG RINSEDYLQM VRDGVSFLEG RGNNLLRELR ERMKMAAEQM NYEEAAFLRD RIRAIEETLE RQRMVSMTFK DQDIFGLYRE GHLIQVCILL IRQGKILGSR LLPLLKFEGE TADMLSSLLM QYYDQSVDIP QEILIPASIE DRQVIREWLE EKRGKGLSIL IPRKGRGLEL LHIAEQNAEH GFKMERKSLD DSDESLRLLM ERLHLRRFPR KIEAFDISNI GGRLAVAAMV TFQDGRPLKS GYRRFRIRTV HGADDYAMMY EALKRRYQGK ENLPDLIVVD GGKGQLAVAF SLLKDLSISG QDVIGLAKER VNGVTVQGGV NKSEDRVYLP HKKEALYLSR WPAVLFLLQR IRDEAHRFAV SYHRSLKTRS DFMSLLDDIP GVGEVRKKAL LLSFGDLARI REATVEELTQ VEGIGKDLGE KIHAFLHNDQ RSVEPSTG //