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Q2LR71 (UVRC_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:SYNAS_07050
ORF Names:SYN_01348
OrganismSyntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]
Taxonomic identifier56780 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618UvrABC system protein C HAMAP-Rule MF_00203
PRO_0000264969

Regions

Domain15 – 9379GIY-YIG
Domain203 – 23836UVR

Sequences

Sequence LengthMass (Da)Tools
Q2LR71 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: D90A769D1192C88D

FASTA61871,119
        10         20         30         40         50         60 
MNRQQLEGRI DIAPRTPGVY LMKDAAGKIL YVGKAKNLKS RTRAYFSGTD SRAMIPFLVS 

        70         80         90        100        110        120 
RIHDIEFILT ETEKEALILE NNLIKEHHPR YNICFRDDKA YFNIRADLNE PFPRFQLVRR 

       130        140        150        160        170        180 
PRKDGAKYFG PYPSSASARE TLQFLQSIFP LRTCRDAELK SRTRPCLEYQ IKRCLAPCVG 

       190        200        210        220        230        240 
RINSEDYLQM VRDGVSFLEG RGNNLLRELR ERMKMAAEQM NYEEAAFLRD RIRAIEETLE 

       250        260        270        280        290        300 
RQRMVSMTFK DQDIFGLYRE GHLIQVCILL IRQGKILGSR LLPLLKFEGE TADMLSSLLM 

       310        320        330        340        350        360 
QYYDQSVDIP QEILIPASIE DRQVIREWLE EKRGKGLSIL IPRKGRGLEL LHIAEQNAEH 

       370        380        390        400        410        420 
GFKMERKSLD DSDESLRLLM ERLHLRRFPR KIEAFDISNI GGRLAVAAMV TFQDGRPLKS 

       430        440        450        460        470        480 
GYRRFRIRTV HGADDYAMMY EALKRRYQGK ENLPDLIVVD GGKGQLAVAF SLLKDLSISG 

       490        500        510        520        530        540 
QDVIGLAKER VNGVTVQGGV NKSEDRVYLP HKKEALYLSR WPAVLFLLQR IRDEAHRFAV 

       550        560        570        580        590        600 
SYHRSLKTRS DFMSLLDDIP GVGEVRKKAL LLSFGDLARI REATVEELTQ VEGIGKDLGE 

       610 
KIHAFLHNDQ RSVEPSTG 

« Hide

References

[1]"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000252 Genomic DNA. Translation: ABC76584.1.
RefSeqYP_460752.1. NC_007759.1.

3D structure databases

ProteinModelPortalQ2LR71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING56780.SYN_01348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC76584; ABC76584; SYN_01348.
GeneID3884766.
KEGGsat:SYN_01348.
PATRIC23861901. VBISynAci70500_0767.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279960.
KOK03703.
OMAQKLFPIR.
OrthoDBEOG6K13R9.

Enzyme and pathway databases

BioCycSACI56780:GHXT-720-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_SYNAS
AccessionPrimary (citable) accession number: Q2LR71
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 21, 2006
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families