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Q2LR71

- UVRC_SYNAS

UniProt

Q2LR71 - UVRC_SYNAS

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Protein

UvrABC system protein C

Gene
uvrC, SYNAS_07050, SYN_01348
Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciSACI56780:GHXT-720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein C
Short name:
Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene namesi
Name:uvrC
Ordered Locus Names:SYNAS_07050
ORF Names:SYN_01348
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618UvrABC system protein CUniRule annotationPRO_0000264969Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex By similarity.

Protein-protein interaction databases

STRINGi56780.SYN_01348.

Structurei

3D structure databases

ProteinModelPortaliQ2LR71.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9379GIY-YIGAdd
BLAST
Domaini203 – 23836UVRAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.
Contains 1 GIY-YIG domain.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279960.
KOiK03703.
OMAiQTIASCV.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LR71-1 [UniParc]FASTAAdd to Basket

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MNRQQLEGRI DIAPRTPGVY LMKDAAGKIL YVGKAKNLKS RTRAYFSGTD    50
SRAMIPFLVS RIHDIEFILT ETEKEALILE NNLIKEHHPR YNICFRDDKA 100
YFNIRADLNE PFPRFQLVRR PRKDGAKYFG PYPSSASARE TLQFLQSIFP 150
LRTCRDAELK SRTRPCLEYQ IKRCLAPCVG RINSEDYLQM VRDGVSFLEG 200
RGNNLLRELR ERMKMAAEQM NYEEAAFLRD RIRAIEETLE RQRMVSMTFK 250
DQDIFGLYRE GHLIQVCILL IRQGKILGSR LLPLLKFEGE TADMLSSLLM 300
QYYDQSVDIP QEILIPASIE DRQVIREWLE EKRGKGLSIL IPRKGRGLEL 350
LHIAEQNAEH GFKMERKSLD DSDESLRLLM ERLHLRRFPR KIEAFDISNI 400
GGRLAVAAMV TFQDGRPLKS GYRRFRIRTV HGADDYAMMY EALKRRYQGK 450
ENLPDLIVVD GGKGQLAVAF SLLKDLSISG QDVIGLAKER VNGVTVQGGV 500
NKSEDRVYLP HKKEALYLSR WPAVLFLLQR IRDEAHRFAV SYHRSLKTRS 550
DFMSLLDDIP GVGEVRKKAL LLSFGDLARI REATVEELTQ VEGIGKDLGE 600
KIHAFLHNDQ RSVEPSTG 618
Length:618
Mass (Da):71,119
Last modified:February 21, 2006 - v1
Checksum:iD90A769D1192C88D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC76584.1.
RefSeqiYP_460752.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC76584; ABC76584; SYN_01348.
GeneIDi3884766.
KEGGisat:SYN_01348.
PATRICi23861901. VBISynAci70500_0767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC76584.1 .
RefSeqi YP_460752.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LR71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_01348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC76584 ; ABC76584 ; SYN_01348 .
GeneIDi 3884766.
KEGGi sat:SYN_01348.
PATRICi 23861901. VBISynAci70500_0767.

Phylogenomic databases

eggNOGi COG0322.
HOGENOMi HOG000279960.
KOi K03703.
OMAi QTIASCV.
OrthoDBi EOG6K13R9.

Enzyme and pathway databases

BioCyci SACI56780:GHXT-720-MONOMER.

Family and domain databases

Gene3Di 3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPi MF_00203. UvrC.
InterProi IPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view ]
Pfami PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view ]
SMARTi SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsi TIGR00194. uvrC. 1 hit.
PROSITEi PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB.

Entry informationi

Entry nameiUVRC_SYNAS
AccessioniPrimary (citable) accession number: Q2LR71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3