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Protein

ATP synthase subunit alpha 1

Gene

atpA1

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei363 – 3631Required for activityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 1778ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI56780:GHXT-643-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alpha 1UniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alpha 1UniRule annotation
F-ATPase subunit alpha 1UniRule annotation
Gene namesi
Name:atpA1UniRule annotation
Ordered Locus Names:SYNAS_06300
ORF Names:SYN_00546
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
Proteomesi
  • UP000001933 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504ATP synthase subunit alpha 1PRO_0000238383Add
BLAST

Proteomic databases

PRIDEiQ2LQZ7.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi56780.SYN_00546.

Structurei

3D structure databases

ProteinModelPortaliQ2LQZ7.
SMRiQ2LQZ7. Positions 18-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG. Bacteria.
COG0056. LUCA.
HOGENOMiHOG000130111.
KOiK02111.
OMAiPVFCIYV.
OrthoDBiPOG091H01QH.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR033732. F1_ATPase_alpha.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LQZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIKAEEIS QIISKQIRDY EKKLDVSETG TVLSVGDGIA RIYGVENAMA
60 70 80 90 100
MELLEFPGGI MGMVLNLEAD NVGVAVLGDV THIKEGDIVK RTGKIAQIPV
110 120 130 140 150
GEALLGRVID ATGEPIDGKG PLGATEFSRI EMIAPGVIKR QPVNEPMYTG
160 170 180 190 200
LKAIDAMTPI GRGQRELIIG DRQIGKTAIG IDAIIRQKDT GVKCIYVAIG
210 220 230 240 250
QKKSTVSQIV ENLRKHDAMS YTCVVAGCAS DPATLQYIAA YAGCSIGEYF
260 270 280 290 300
RDRGQDALII YDDLSKQAVA YRQISLLLRR PPGREAYPGD IFYNHSRLLE
310 320 330 340 350
RSARVSADLG GGSLTALPII ETQAGDVSAY IPTNVISITD GQVYLEPSLF
360 370 380 390 400
FSGIRPAINV GLSVSRVGGA AQVKAMKQVA GTLKLDLAQY RELASFAQFG
410 420 430 440 450
SDLDKATQAQ LDRGVRLVEI LKQPQFQPMS LAEEVIVLFA GTRGFLDKYE
460 470 480 490 500
VEKIKEYEPQ VLAYMKSKHQ DIMQEIDDKK VISPELEQKI KEALTAFDSV

FVAG
Length:504
Mass (Da):54,762
Last modified:February 21, 2006 - v1
Checksum:i0BDC425675C3243E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA. Translation: ABC76509.1.
RefSeqiWP_011416543.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC76509; ABC76509; SYN_00546.
KEGGisat:SYN_00546.
PATRICi23861739. VBISynAci70500_0688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA. Translation: ABC76509.1.
RefSeqiWP_011416543.1. NC_007759.1.

3D structure databases

ProteinModelPortaliQ2LQZ7.
SMRiQ2LQZ7. Positions 18-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi56780.SYN_00546.

Proteomic databases

PRIDEiQ2LQZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC76509; ABC76509; SYN_00546.
KEGGisat:SYN_00546.
PATRICi23861739. VBISynAci70500_0688.

Phylogenomic databases

eggNOGiENOG4105CDG. Bacteria.
COG0056. LUCA.
HOGENOMiHOG000130111.
KOiK02111.
OMAiPVFCIYV.
OrthoDBiPOG091H01QH.

Enzyme and pathway databases

BioCyciSACI56780:GHXT-643-MONOMER.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR033732. F1_ATPase_alpha.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPA1_SYNAS
AccessioniPrimary (citable) accession number: Q2LQZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 21, 2006
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.