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Q2LQZ7 (ATPA1_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha 1
EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha 1
F-ATPase subunit alpha 1
Gene names
Name:atpA1
Ordered Locus Names:SYNAS_06300
ORF Names:SYN_00546
OrganismSyntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]
Taxonomic identifier56780 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Syntrophobacterales › Syntrophaceae › Syntrophus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504ATP synthase subunit alpha 1 HAMAP MF_01346
PRO_0000238383

Regions

Nucleotide binding170 – 1778ATP By similarity

Sites

Site3631Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2LQZ7 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: 0BDC425675C3243E

FASTA50454,762
        10         20         30         40         50         60 
MDTIKAEEIS QIISKQIRDY EKKLDVSETG TVLSVGDGIA RIYGVENAMA MELLEFPGGI 

        70         80         90        100        110        120 
MGMVLNLEAD NVGVAVLGDV THIKEGDIVK RTGKIAQIPV GEALLGRVID ATGEPIDGKG 

       130        140        150        160        170        180 
PLGATEFSRI EMIAPGVIKR QPVNEPMYTG LKAIDAMTPI GRGQRELIIG DRQIGKTAIG 

       190        200        210        220        230        240 
IDAIIRQKDT GVKCIYVAIG QKKSTVSQIV ENLRKHDAMS YTCVVAGCAS DPATLQYIAA 

       250        260        270        280        290        300 
YAGCSIGEYF RDRGQDALII YDDLSKQAVA YRQISLLLRR PPGREAYPGD IFYNHSRLLE 

       310        320        330        340        350        360 
RSARVSADLG GGSLTALPII ETQAGDVSAY IPTNVISITD GQVYLEPSLF FSGIRPAINV 

       370        380        390        400        410        420 
GLSVSRVGGA AQVKAMKQVA GTLKLDLAQY RELASFAQFG SDLDKATQAQ LDRGVRLVEI 

       430        440        450        460        470        480 
LKQPQFQPMS LAEEVIVLFA GTRGFLDKYE VEKIKEYEPQ VLAYMKSKHQ DIMQEIDDKK 

       490        500 
VISPELEQKI KEALTAFDSV FVAG

« Hide

References

[1]"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000252 Genomic DNA. Translation: ABC76509.1.
RefSeqYP_460677.1. NC_007759.1.

3D structure databases

ProteinModelPortalQ2LQZ7.
SMRQ2LQZ7. Positions 18-501.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2LQZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3884822.
GenomeReviewsGene locus SYNAS_06300 in contig CP000252_GR.
KEGGsat:SYN_00546.
NMPDRfig|56780.10.peg.624.
PATRIC23861739. VBISynAci70500_0688.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0056.
HOGENOMHBG565875.
OMAFRVGIKA.
PhylomeDBQ2LQZ7.
ProtClustDBPRK09281.

Enzyme and pathway databases

BioCycSACI56780:SYN_00546-MONOMER.

Family and domain databases

HAMAPMF_01346. ATP_synth_alpha_bact.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR005294. ATPase_F1-cplx_asu.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
Gene3DG3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KOK02111.
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR00962. AtpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA1_SYNAS
AccessionPrimary (citable) accession number: Q2LQZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 21, 2006
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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