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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102ZincUniRule annotation1
Metal bindingi104ZincUniRule annotation1
Metal bindingi129ZincUniRule annotation1
Metal bindingi131ZincUniRule annotation1
Binding sitei242ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSACI56780:G1G5X-183-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:SYNAS_01920
ORF Names:SYN_02557
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
Proteomesi
  • UP000001933 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002374131 – 472Glutamate--tRNA ligase 1Add BLAST472

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi56780.SYN_02557

Structurei

3D structure databases

ProteinModelPortaliQ2LQN4
SMRiQ2LQN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 23"HIGH" regionUniRule annotationAdd BLAST11
Motifi239 – 243"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q2LQN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLKEIRTR FAPSPTGYLH IGGARTALFS WLYARHHQGK FVLRIEDTDQ
60 70 80 90 100
LRSTEESTRA ILDAMTWLGL NWDEGPVFQA ERVDIHRAMI RKLVDEDKAY
110 120 130 140 150
YCTCTPDELE EKRKRALAEG RKPKYDGTCR EKKLPPSPGT VVRFRCPQTG
160 170 180 190 200
ITVVDDLIKG KISFNNEELD DLIIQRSDGY PTYNFAVVVD DAQMGISHVI
210 220 230 240 250
RGDDHVNNTP RQILLYQALG YDIPHFGHVP MILGADKARL SKRHGATSVM
260 270 280 290 300
AYKDMGYLPE ALVNYLVRLG WSHGDQEIFS LDELIALFGL ESIGKSAAVF
310 320 330 340 350
NPEKLLWLNQ HYIKTYPEDR LLEVLQPFWK QLGIEAPDPD YGRSIVRDLR
360 370 380 390 400
ARAKTLVDMA ESSTFYFNDE PAIDADAAKK FLTPEIAGHL EAIAEALATL
410 420 430 440 450
GDYSKEGIEI FLRSLVEARA IKLKTIAQPL RIALTGKTVS PGLDDIMLTL
460 470
GKERVIARIQ RTVAYIRSGM AS
Length:472
Mass (Da):53,248
Last modified:February 21, 2006 - v1
Checksum:i4A1ED73395B51DE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000252 Genomic DNA Translation: ABC76071.1
RefSeqiWP_011416106.1, NC_007759.1

Genome annotation databases

EnsemblBacteriaiABC76071; ABC76071; SYN_02557
KEGGisat:SYN_02557

Similar proteinsi

Entry informationi

Entry nameiSYE1_SYNAS
AccessioniPrimary (citable) accession number: Q2LQN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 21, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health