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Q2LQK5

- SYL_SYNAS

UniProt

Q2LQK5 - SYL_SYNAS

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Protein
Leucine--tRNA ligase
Gene
leuS, SYNAS_01790, SYN_02374
Organism
Syntrophus aciditrophicus (strain SB)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei617 – 6171ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI56780:GHXT-182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SYNAS_01790
ORF Names:SYN_02374
OrganismiSyntrophus aciditrophicus (strain SB)
Taxonomic identifieri56780 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus
ProteomesiUP000001933: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligaseUniRule annotation
PRO_1000009453Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi56780.SYN_02374.

Structurei

3D structure databases

ProteinModelPortaliQ2LQK5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi614 – 6185"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LQK5-1 [UniParc]FASTAAdd to Basket

« Hide

MNRKYVPQEI EEKWQRYWEE KNTFKVTEDP SKKKYYLLEM FPYPSGKIHI    50
GHVRNYTIGD VVARYKRMEG YNVLHPMGWD SFGMPAENAA IERGIHPSLW 100
TNENITHMRK QLKRMGFSYD WDREVSTCEP VYYRWEQLFF LWMYEKGLAY 150
KKTSSVNWCP RCQTVLANEQ VEAGLCWRCG SEVVEKILDQ WFFRITAYID 200
ELLAGCDRLT GWPERVLTMQ RNWIGKSYGC EVSFPMADGN GDIKVFTTRQ 250
DTLFGATFML IAAEHPLVME LIKGKPVEKD ARTFAEEVKK QDKLMRTSDY 300
YEKQGLFLDC YCLNPLTGWE MPIFATNFVL ADYGTGCVMA VPTHDQRDFE 350
FAEKFGLRKV VVISPPDKTL DPETMTEAYV EEGILVNSGP FNGMENLKAL 400
DAIADHLIAL GRGKRTIQYR LRDWGISRQR YWGAPIPMIM CPKCGTVPVP 450
EAELPVVLPR DVDFSGEGGS PLAKHPEFLN TTCPSCGGPA KRESDTMDTF 500
VESSWYFERY CCPHFAEKPG LNRQQVDYWM PVDQYIGGIE HAILHLLYAR 550
FYTRMLRDFG LVGVDEPFTN LLTQGMVCKE TTRCPDHGYL YPEEVREGRC 600
IHCLAEVIVG KTEKMSKSLK NVVDPDYLVR QYGADTARMF CLFAAPPEKD 650
LEWSDQGVEG SFRFIGRTWR IVVDYLDDLQ GIAPFAGDGE LEGELKSLRR 700
KTHQTIRKVR DDMGERFHFN TAISAIMELV NTLYGLPRPP REDRTALAVI 750
RETIEAIILL LAPIVPHLTE ELWQMLGHQG TCLADTPLPV YDPTVAAEDE 800
MTIVIQVNGK VRSRVIVAAD EAEDKIKALA MGDEKVSRFL EGKSVIKQVY 850
VPKKLVNIVV KG 862
Length:862
Mass (Da):98,777
Last modified:February 21, 2006 - v1
Checksum:iE81B3D4E8454F1A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC76058.1.
RefSeqiYP_460226.1. NC_007759.1.

Genome annotation databases

EnsemblBacteriaiABC76058; ABC76058; SYN_02374.
GeneIDi3884478.
KEGGisat:SYN_02374.
PATRICi23860731. VBISynAci70500_0194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000252 Genomic DNA. Translation: ABC76058.1 .
RefSeqi YP_460226.1. NC_007759.1.

3D structure databases

ProteinModelPortali Q2LQK5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 56780.SYN_02374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC76058 ; ABC76058 ; SYN_02374 .
GeneIDi 3884478.
KEGGi sat:SYN_02374.
PATRICi 23860731. VBISynAci70500_0194.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SACI56780:GHXT-182-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
    Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB.

Entry informationi

Entry nameiSYL_SYNAS
AccessioniPrimary (citable) accession number: Q2LQK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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