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Q2LQK5 (SYL_SYNAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:SYNAS_01790
ORF Names:SYN_02374
OrganismSyntrophus aciditrophicus (strain SB) [Complete proteome] [HAMAP]
Taxonomic identifier56780 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeSyntrophus

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 862862Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009453

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif614 – 6185"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6171ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2LQK5 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: E81B3D4E8454F1A9

FASTA86298,777
        10         20         30         40         50         60 
MNRKYVPQEI EEKWQRYWEE KNTFKVTEDP SKKKYYLLEM FPYPSGKIHI GHVRNYTIGD 

        70         80         90        100        110        120 
VVARYKRMEG YNVLHPMGWD SFGMPAENAA IERGIHPSLW TNENITHMRK QLKRMGFSYD 

       130        140        150        160        170        180 
WDREVSTCEP VYYRWEQLFF LWMYEKGLAY KKTSSVNWCP RCQTVLANEQ VEAGLCWRCG 

       190        200        210        220        230        240 
SEVVEKILDQ WFFRITAYID ELLAGCDRLT GWPERVLTMQ RNWIGKSYGC EVSFPMADGN 

       250        260        270        280        290        300 
GDIKVFTTRQ DTLFGATFML IAAEHPLVME LIKGKPVEKD ARTFAEEVKK QDKLMRTSDY 

       310        320        330        340        350        360 
YEKQGLFLDC YCLNPLTGWE MPIFATNFVL ADYGTGCVMA VPTHDQRDFE FAEKFGLRKV 

       370        380        390        400        410        420 
VVISPPDKTL DPETMTEAYV EEGILVNSGP FNGMENLKAL DAIADHLIAL GRGKRTIQYR 

       430        440        450        460        470        480 
LRDWGISRQR YWGAPIPMIM CPKCGTVPVP EAELPVVLPR DVDFSGEGGS PLAKHPEFLN 

       490        500        510        520        530        540 
TTCPSCGGPA KRESDTMDTF VESSWYFERY CCPHFAEKPG LNRQQVDYWM PVDQYIGGIE 

       550        560        570        580        590        600 
HAILHLLYAR FYTRMLRDFG LVGVDEPFTN LLTQGMVCKE TTRCPDHGYL YPEEVREGRC 

       610        620        630        640        650        660 
IHCLAEVIVG KTEKMSKSLK NVVDPDYLVR QYGADTARMF CLFAAPPEKD LEWSDQGVEG 

       670        680        690        700        710        720 
SFRFIGRTWR IVVDYLDDLQ GIAPFAGDGE LEGELKSLRR KTHQTIRKVR DDMGERFHFN 

       730        740        750        760        770        780 
TAISAIMELV NTLYGLPRPP REDRTALAVI RETIEAIILL LAPIVPHLTE ELWQMLGHQG 

       790        800        810        820        830        840 
TCLADTPLPV YDPTVAAEDE MTIVIQVNGK VRSRVIVAAD EAEDKIKALA MGDEKVSRFL 

       850        860 
EGKSVIKQVY VPKKLVNIVV KG 

« Hide

References

[1]"The genome of the syntrophic bacterium Syntrophus aciditrophicus: Life dependent on negative change in electrical potential."
Gunsalus R., Rohlin L., Kim U., Krupp R., Bhattacharyya A., Campbell J., Mclerney M., Moutakki H., Rio-Hernandez L.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000252 Genomic DNA. Translation: ABC76058.1.
RefSeqYP_460226.1. NC_007759.1.

3D structure databases

ProteinModelPortalQ2LQK5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING56780.SYN_02374.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC76058; ABC76058; SYN_02374.
GeneID3884478.
KEGGsat:SYN_02374.
PATRIC23860731. VBISynAci70500_0194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycSACI56780:GHXT-182-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SYNAS
AccessionPrimary (citable) accession number: Q2LQK5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries