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Protein

Toll-interacting protein

Gene

TOLLIP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-BTA-446652. Interleukin-1 signaling.
R-BTA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-interacting protein
Gene namesi
Name:TOLLIP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003849312 – 273Toll-interacting proteinAdd BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei273PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2LGB5.
PeptideAtlasiQ2LGB5.
PRIDEiQ2LGB5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008237.

Interactioni

Subunit structurei

Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2 (By similarity). Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010835.

Structurei

3D structure databases

ProteinModelPortaliQ2LGB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 135C2Add BLAST96
Domaini228 – 271CUEPROSITE-ProRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 136AIM14
Motifi151 – 154AIM24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 34Poly-Gln7

Domaini

Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.By similarity

Sequence similaritiesi

Belongs to the tollip family.Curated
Contains 1 C2 domain.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IE45. Eukaryota.
ENOG410XQPY. LUCA.
GeneTreeiENSGT00390000013104.
HOGENOMiHOG000293427.
InParanoidiQ2LGB5.
KOiK05402.
OMAiHVTIPES.
OrthoDBiEOG091G0JE1.
TreeFamiTF324180.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2LGB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTVSTQRG PVYIGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGALG
60 70 80 90 100
TVGRLSVTVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW
110 120 130 140 150
NKVIQCTVPP GVDSFYLEIF DERAFSMDDR IAWTHVTIPE ALKQGKVVDE
160 170 180 190 200
WYSLSGRQGD DKEGMINLVL SYTSLPAAMM MPPQPVVLMP TVYQQGVGYV
210 220 230 240 250
PITGMPTVCS PGVVPVALPP AVSAQPRCSE EDLKAIQDMF PNMDREVIRS
260 270
VLEAQRGSRD AAINSLLQMG EES
Length:273
Mass (Da):30,082
Last modified:February 21, 2006 - v1
Checksum:iE74C60B1CADE8B9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56S → I in ABD72515 (Ref. 2) Curated1
Sequence conflicti56S → I in AAX46632 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ319073 mRNA. Translation: ABC47876.1.
DQ407275 mRNA. Translation: ABD72515.1.
BT021785 mRNA. Translation: AAX46632.1.
BC123457 mRNA. Translation: AAI23458.1.
RefSeqiNP_001035050.1. NM_001039961.1.
UniGeneiBt.10935.

Genome annotation databases

EnsembliENSBTAT00000010835; ENSBTAP00000010835; ENSBTAG00000008237.
GeneIDi539480.
KEGGibta:539480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ319073 mRNA. Translation: ABC47876.1.
DQ407275 mRNA. Translation: ABD72515.1.
BT021785 mRNA. Translation: AAX46632.1.
BC123457 mRNA. Translation: AAI23458.1.
RefSeqiNP_001035050.1. NM_001039961.1.
UniGeneiBt.10935.

3D structure databases

ProteinModelPortaliQ2LGB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010835.

Proteomic databases

PaxDbiQ2LGB5.
PeptideAtlasiQ2LGB5.
PRIDEiQ2LGB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010835; ENSBTAP00000010835; ENSBTAG00000008237.
GeneIDi539480.
KEGGibta:539480.

Organism-specific databases

CTDi54472.

Phylogenomic databases

eggNOGiENOG410IE45. Eukaryota.
ENOG410XQPY. LUCA.
GeneTreeiENSGT00390000013104.
HOGENOMiHOG000293427.
InParanoidiQ2LGB5.
KOiK05402.
OMAiHVTIPES.
OrthoDBiEOG091G0JE1.
TreeFamiTF324180.

Enzyme and pathway databases

ReactomeiR-BTA-446652. Interleukin-1 signaling.
R-BTA-6798695. Neutrophil degranulation.

Gene expression databases

BgeeiENSBTAG00000008237.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOLIP_BOVIN
AccessioniPrimary (citable) accession number: Q2LGB5
Secondary accession number(s): Q58D12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 21, 2006
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.