ID   NDUS2_DICCI             Reviewed;         406 AA.
AC   Q2LCR5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit;
DE            EC=1.6.5.3;
DE            EC=1.6.99.3;
DE   AltName: Full=NADH dehydrogenase subunit 7;
GN   Name=nad7; Synonyms=ndufs2;
OS   Dictyostelium citrinum (Slime mold).
OG   Mitochondrion.
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=361072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18413355; DOI=10.1093/molbev/msn088;
RA   Heidel A.J., Gloeckner G.;
RT   "Mitochondrial genome evolution in the social amoebae.";
RL   Mol. Biol. Evol. 25:1440-1450(2008).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). Component of the iron-sulfur (IP)
CC       fragment of the enzyme. Component of the iron-sulfur (IP) fragment
CC       of the enzyme (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
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DR   EMBL; DQ336395; ABC60378.1; -; Genomic_DNA.
DR   RefSeq; YP_492627.1; -.
DR   GeneID; 3912609; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010219; NADH_DH_1_dsu.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR014029; NADH_UbQ_OxRdtase_su-49kDa_CS.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   TIGRFAMs; TIGR01962; NuoD; 1.
DR   PROSITE; PS00535; COMPLEX1_49K; 1.
PE   3: Inferred from homology;
KW   Electron transport; Mitochondrion; NAD; Oxidoreductase;
KW   Respiratory chain; Transport; Ubiquinone.
FT   CHAIN         1    406       NADH-ubiquinone oxidoreductase 49 kDa
FT                                subunit.
FT                                /FTId=PRO_0000312396.
SQ   SEQUENCE   406 AA;  46817 MW;  5811AF68D71F86BA CRC64;
     MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI GLLHRGTEKL
     IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL DIELEIPQRA KVIRVLFSEI
     TRVLNHIMAT TTHAMDVGAL TPFLWAFEER EKLMEFYERV SGARMHAAYI RPGGVAFDLP
     MNISEDIYKF VIQYRKRLEE IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG
     IVYDIRKNYP YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLAIIEQA LNNLRPGLIK
     LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF GIYLNANDTA
     KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV FGEVDR
//