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Q2LCR5

- NDUS2_DICCI

UniProt

Q2LCR5 - NDUS2_DICCI

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Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene
nad7, ndufs2
Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.UniRule annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation
NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  3. quinone binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:nad7
Synonyms:ndufs2
Encoded oniMitochondrion
OrganismiDictyostelium citrinum (Slime mold)
Taxonomic identifieri361072 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406NADH-ubiquinone oxidoreductase 49 kDa subunitUniRule annotationPRO_0000312396Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2LCR5.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.645.10. 2 hits.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LCR5-1 [UniParc]FASTAAdd to Basket

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MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI    50
GLLHRGTEKL IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL 100
DIELEIPQRA KVIRVLFSEI TRVLNHIMAT TTHAMDVGAL TPFLWAFEER 150
EKLMEFYERV SGARMHAAYI RPGGVAFDLP MNISEDIYKF VIQYRKRLEE 200
IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG IVYDIRKNYP 250
YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLAIIEQA LNNLRPGLIK 300
LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF 350
GIYLNANDTA KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV 400
FGEVDR 406
Length:406
Mass (Da):46,817
Last modified:February 21, 2006 - v1
Checksum:i5811AF68D71F86BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60378.1.
RefSeqiYP_492627.1. NC_007787.2.

Genome annotation databases

GeneIDi3912609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60378.1 .
RefSeqi YP_492627.1. NC_007787.2.

3D structure databases

ProteinModelPortali Q2LCR5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3912609.

Family and domain databases

Gene3Di 1.10.645.10. 2 hits.
HAMAPi MF_01358. NDH1_NuoD.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial genome evolution in the social amoebae."
    Heidel A.J., Gloeckner G.
    Mol. Biol. Evol. 25:1440-1450(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNDUS2_DICCI
AccessioniPrimary (citable) accession number: Q2LCR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 21, 2006
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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