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Q2LCR5

- NDUS2_DICCI

UniProt

Q2LCR5 - NDUS2_DICCI

Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

nad7

Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    3. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:nad7
    Synonyms:ndufs2
    Encoded oniMitochondrion
    OrganismiDictyostelium citrinum (Slime mold)
    Taxonomic identifieri361072 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406NADH-ubiquinone oxidoreductase 49 kDa subunitPRO_0000312396Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LCR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Curated

    Family and domain databases

    Gene3Di1.10.645.10. 2 hits.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LCR5-1 [UniParc]FASTAAdd to Basket

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    MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI    50
    GLLHRGTEKL IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL 100
    DIELEIPQRA KVIRVLFSEI TRVLNHIMAT TTHAMDVGAL TPFLWAFEER 150
    EKLMEFYERV SGARMHAAYI RPGGVAFDLP MNISEDIYKF VIQYRKRLEE 200
    IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG IVYDIRKNYP 250
    YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLAIIEQA LNNLRPGLIK 300
    LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF 350
    GIYLNANDTA KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV 400
    FGEVDR 406
    Length:406
    Mass (Da):46,817
    Last modified:February 21, 2006 - v1
    Checksum:i5811AF68D71F86BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ336395 Genomic DNA. Translation: ABC60378.1.
    RefSeqiYP_492627.1. NC_007787.2.

    Genome annotation databases

    GeneIDi3912609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ336395 Genomic DNA. Translation: ABC60378.1 .
    RefSeqi YP_492627.1. NC_007787.2.

    3D structure databases

    ProteinModelPortali Q2LCR5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3912609.

    Family and domain databases

    Gene3Di 1.10.645.10. 2 hits.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mitochondrial genome evolution in the social amoebae."
      Heidel A.J., Gloeckner G.
      Mol. Biol. Evol. 25:1440-1450(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNDUS2_DICCI
    AccessioniPrimary (citable) accession number: Q2LCR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3