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Reviewed, UniProtKB/Swiss-Prot Q2LCR5 (NDUS2_DICCI)

Last modified November 25, 2008. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH dehydrogenase subunit 7
Gene names
Name: nad7
Synonyms: ndufs2
Encoded onMitochondrion
OrganismDictyostelium citrinum (Slime mold)
Taxonomic identifier361072 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Catalytic activity

NADH + ubiquinone = NAD(+) + ubiquinol.

NADH + acceptor = NAD(+) + reduced acceptor.

Subcellular location

MitochondrionBy similarity.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406NADH-ubiquinone oxidoreductase 49 kDa subunit
PRO_0000312396

Sequences

Sequence LengthMass (Da)Tools
Q2LCR5-1 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: 5811AF68D71F86BA

FASTA40646,817
        10         20         30         40         50         60 
MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI GLLHRGTEKL 

        70         80         90        100        110        120 
IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL DIELEIPQRA KVIRVLFSEI 

       130        140        150        160        170        180 
TRVLNHIMAT TTHAMDVGAL TPFLWAFEER EKLMEFYERV SGARMHAAYI RPGGVAFDLP 

       190        200        210        220        230        240 
MNISEDIYKF VIQYRKRLEE IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG 

       250        260        270        280        290        300 
IVYDIRKNYP YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLAIIEQA LNNLRPGLIK 

       310        320        330        340        350        360 
LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF GIYLNANDTA 

       370        380        390        400 
KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV FGEVDR 

« Hide

References

[1]"Mitochondrial genome evolution in the social amoebae."
Heidel A.J., Gloeckner G.
Mol. Biol. Evol. 25:1440-1450(2008) [PubMed: 18413355] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

DQ336395 Genomic DNA. Translation: ABC60378.1.
RefSeqYP_492627.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3912609.

Family and domain databases

InterProIPR014029. NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219. NADH_DH_1_dsu.
IPR001135. NADH_UbQ_OxRdtase_49kDa.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_DICCI
AccessionPrimary (citable) accession number: Q2LCR5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 21, 2006
Last modified: November 25, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents