Reviewed, UniProtKB/Swiss-Prot Q2LCR4 (NDUS3_DICCI)

Names and origin

Protein names

Recommended name:
    NADH-ubiquinone oxidoreductase subunit 9
    EC=1.6.5.3
    EC=1.6.99.3

Gene names

Name:	nad9
Synonyms:	ndufs3

Encoded on

Mitochondrion

Organism

Dictyostelium citrinum (Slime mold)

Taxonomic identifier

361072 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subunit structure	Complex I is composed of about 30 different subunits.
Subcellular location	Mitochondrion inner membrane By similarity.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	NADH-ubiquinone oxidoreductase subunit 9		PRO_0000312397

Sequences

	Sequence		Length	Mass (Da)
	Q2LCR4-1 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: 0C609399DD0D0484	FASTA	209	24,881
	10 20 30 40 50 60 MKDYKNELKV KVDLGENLRG SIPGLIKKVM YKTQYLEIQV EKKNLLPVLR FLKESSKYQC 70 80 90 100 110 120 TMLLDIVCID CLNIEEIKIG RFKIIYVLNS IYNNTRVHIS TYVENNGIIE TTSGLFESSV 130 140 150 160 170 180 WLEREIWDMF GIYFEKHPDL RRILTDYGFV GYPLKKDFPI TGYLEVYYDV ADKKIIYKPI 190 200 ELMQEYRNYN FGAVWGDYER KVYLENIIK

References

[1]	"Mitochondrial genome evolution in the social amoebae." Heidel A.J., Gloeckner G. Mol. Biol. Evol. 25:1440-1450(2008) [PubMed: 18413355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ336395 Genomic DNA. Translation: ABC60379.1.
RefSeq	YP_492628.1.
3D structure databases
SMR	Q2LCR4. Positions 35-203.
ModBase	Search...
Genome annotation databases
GeneID	3912610.
Family and domain databases
InterPro	IPR001268. NADH_UbQ_OxRdtase_30kDa_su. IPR020396. NADH_UbQ_OxRdtase_CS. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00542. COMPLEX1_30K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS3_DICCI

Accession

Primary (citable) accession number: Q2LCR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	February 21, 2006
Last modified:	January 19, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)