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Q2LCQ6

- COX1_DICCI

UniProt

Q2LCQ6 - COX1_DICCI

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Protein
Cytochrome c oxidase subunit 1+2
Gene
cox1/2
Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron (heme A axial ligand) By similarity
Metal bindingi264 – 2641Copper B By similarity
Metal bindingi268 – 2681Copper B By similarity
Metal bindingi314 – 3141Copper B By similarity
Metal bindingi315 – 3151Copper B By similarity
Metal bindingi400 – 4001Iron (heme A3 axial ligand) By similarity
Metal bindingi402 – 4021Iron (heme A axial ligand) By similarity
Metal bindingi709 – 7091Copper A By similarity
Metal bindingi744 – 7441Copper A By similarity
Metal bindingi748 – 7481Copper A By similarity
Metal bindingi752 – 7521Copper A By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:cox1/2
Encoded oniMitochondrion
OrganismiDictyostelium citrinum (Slime mold)
Taxonomic identifieri361072 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121Helical; Reviewed prediction
Add
BLAST
Transmembranei87 – 11125Helical; Reviewed prediction
Add
BLAST
Transmembranei130 – 15021Helical; Reviewed prediction
Add
BLAST
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Transmembranei211 – 23121Helical; Reviewed prediction
Add
BLAST
Transmembranei262 – 27817Helical; Reviewed prediction
Add
BLAST
Transmembranei290 – 31021Helical; Reviewed prediction
Add
BLAST
Transmembranei335 – 35521Helical; Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Reviewed prediction
Add
BLAST
Transmembranei396 – 41621Helical; Reviewed prediction
Add
BLAST
Transmembranei444 – 46421Helical; Reviewed prediction
Add
BLAST
Transmembranei483 – 50321Helical; Reviewed prediction
Add
BLAST
Transmembranei555 – 57521Helical; Reviewed prediction
Add
BLAST
Transmembranei604 – 62421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Cytochrome c oxidase subunit 1+2
PRO_0000312386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2LCQ6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 491491COX1
Add
BLAST
Regioni492 – 773282COX2
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LCQ6-1 [UniParc]FASTAAdd to Basket

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MKLLEIYDKQ LVEQEEGGFR AILTRYLNKW IFTVDHKLIG TMYITFSIFA    50
GIIGTLLSLV IPMELSTGNM LEGDSQQYNV IVTAHGLIMI FFVVMYCSMP 100
AMLGGFANWF LPIMVGAPDV AFPRLNNISL WLIVVSFGLL LTSSCVGIGA 150
GTGWTVYPPL SMMEYHPGHA VDVGILSLHI AGASSLVGAI NFLTTVFNMK 200
IAGLSWPKVS LFVWSVVITA VLLVLSLPVL AGGLTMLITD RNFETTFFDP 250
IGGGDPILYQ HLFHPEVYIL ILPGFGIISI IISRYSNKGI FGVKGMISAM 300
SAIGFLGFLV WAYHHMYTVG LDVDTRAYFT AATMIIAIPT GIKIFSWLAT 350
LWGGVIKITT PMLFVIGFLV LFTIGGLTGV VLANGGLDIS LHDTYYVVAH 400
FHYVLSMGAI FAIFAGYYYY YAIMNSNRIL GIVRYNEQLG RIHFWTMFIG 450
VNVTFFPMHF LGLAGMPRRI GDYPDAYIGW NLIASYGSLI TAFGLLFFFV 500
NIFTPYFKKK ALISKKFQRG AMILMGLDFS RDWQIGFQDP ATPIMEGIID 550
LHNYIFFYLI VVAVFIGWVM GRILWRFAYK WSYPTIGDIE IFKNFTAYNQ 600
IIHGTVIEIV WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW 650
YWSYEYGDNS SNLVEFDSYM VYERDLNEGQ LRLLEVDNSM IVPVKTHIRL 700
IITSGDVLHS WAVPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV 750
DHGFMPIKVE AVKVQEYLGR LYK 773
Length:773
Mass (Da):86,778
Last modified:February 21, 2006 - v1
Checksum:iDBAB29E1527D1BD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60387.1.
RefSeqiYP_492636.2. NC_007787.2.

Genome annotation databases

GeneIDi3912629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60387.1 .
RefSeqi YP_492636.2. NC_007787.2.

3D structure databases

ProteinModelPortali Q2LCQ6.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3912629.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial genome evolution in the social amoebae."
    Heidel A.J., Gloeckner G.
    Mol. Biol. Evol. 25:1440-1450(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCOX1_DICCI
AccessioniPrimary (citable) accession number: Q2LCQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 21, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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