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Q2LCQ6

- COX1_DICCI

UniProt

Q2LCQ6 - COX1_DICCI

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Protein

Cytochrome c oxidase subunit 1+2

Gene

cox1/2

Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron (heme A axial ligand)By similarity
Metal bindingi264 – 2641Copper BBy similarity
Metal bindingi268 – 2681Copper BBy similarity
Metal bindingi314 – 3141Copper BBy similarity
Metal bindingi315 – 3151Copper BBy similarity
Metal bindingi400 – 4001Iron (heme A3 axial ligand)By similarity
Metal bindingi402 – 4021Iron (heme A axial ligand)By similarity
Metal bindingi709 – 7091Copper ABy similarity
Metal bindingi744 – 7441Copper ABy similarity
Metal bindingi748 – 7481Copper ABy similarity
Metal bindingi752 – 7521Copper ABy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:cox1/2
Encoded oniMitochondrion
OrganismiDictyostelium citrinum (Slime mold)
Taxonomic identifieri361072 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Cytochrome c oxidase subunit 1+2PRO_0000312386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2LCQ6.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 11125HelicalSequence AnalysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 27817HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence AnalysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence AnalysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence AnalysisAdd
BLAST
Transmembranei483 – 50321HelicalSequence AnalysisAdd
BLAST
Transmembranei555 – 57521HelicalSequence AnalysisAdd
BLAST
Transmembranei604 – 62421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 491491COX1Add
BLAST
Regioni492 – 773282COX2Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LCQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLEIYDKQ LVEQEEGGFR AILTRYLNKW IFTVDHKLIG TMYITFSIFA
60 70 80 90 100
GIIGTLLSLV IPMELSTGNM LEGDSQQYNV IVTAHGLIMI FFVVMYCSMP
110 120 130 140 150
AMLGGFANWF LPIMVGAPDV AFPRLNNISL WLIVVSFGLL LTSSCVGIGA
160 170 180 190 200
GTGWTVYPPL SMMEYHPGHA VDVGILSLHI AGASSLVGAI NFLTTVFNMK
210 220 230 240 250
IAGLSWPKVS LFVWSVVITA VLLVLSLPVL AGGLTMLITD RNFETTFFDP
260 270 280 290 300
IGGGDPILYQ HLFHPEVYIL ILPGFGIISI IISRYSNKGI FGVKGMISAM
310 320 330 340 350
SAIGFLGFLV WAYHHMYTVG LDVDTRAYFT AATMIIAIPT GIKIFSWLAT
360 370 380 390 400
LWGGVIKITT PMLFVIGFLV LFTIGGLTGV VLANGGLDIS LHDTYYVVAH
410 420 430 440 450
FHYVLSMGAI FAIFAGYYYY YAIMNSNRIL GIVRYNEQLG RIHFWTMFIG
460 470 480 490 500
VNVTFFPMHF LGLAGMPRRI GDYPDAYIGW NLIASYGSLI TAFGLLFFFV
510 520 530 540 550
NIFTPYFKKK ALISKKFQRG AMILMGLDFS RDWQIGFQDP ATPIMEGIID
560 570 580 590 600
LHNYIFFYLI VVAVFIGWVM GRILWRFAYK WSYPTIGDIE IFKNFTAYNQ
610 620 630 640 650
IIHGTVIEIV WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW
660 670 680 690 700
YWSYEYGDNS SNLVEFDSYM VYERDLNEGQ LRLLEVDNSM IVPVKTHIRL
710 720 730 740 750
IITSGDVLHS WAVPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV
760 770
DHGFMPIKVE AVKVQEYLGR LYK
Length:773
Mass (Da):86,778
Last modified:February 21, 2006 - v1
Checksum:iDBAB29E1527D1BD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60387.1.
RefSeqiYP_492636.2. NC_007787.2.

Genome annotation databases

GeneIDi3912629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60387.1 .
RefSeqi YP_492636.2. NC_007787.2.

3D structure databases

ProteinModelPortali Q2LCQ6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3912629.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial genome evolution in the social amoebae."
    Heidel A.J., Gloeckner G.
    Mol. Biol. Evol. 25:1440-1450(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCOX1_DICCI
AccessioniPrimary (citable) accession number: Q2LCQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3