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Protein

Cytochrome c oxidase subunit 1+2

Gene

cox1/2

Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Iron (heme A axial ligand)By similarity1
Metal bindingi264Copper BBy similarity1
Metal bindingi268Copper BBy similarity1
Metal bindingi314Copper BBy similarity1
Metal bindingi315Copper BBy similarity1
Metal bindingi400Iron (heme A3 axial ligand)By similarity1
Metal bindingi402Iron (heme A axial ligand)By similarity1
Metal bindingi709Copper ABy similarity1
Metal bindingi744Copper ABy similarity1
Metal bindingi748Copper ABy similarity1
Metal bindingi752Copper ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:cox1/2
Encoded oniMitochondrion
OrganismiDictyostelium citrinum (Slime mold)
Taxonomic identifieri361072 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei87 – 111HelicalSequence analysisAdd BLAST25
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei262 – 278HelicalSequence analysisAdd BLAST17
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123861 – 773Cytochrome c oxidase subunit 1+2Add BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2LCQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 491COX1Add BLAST491
Regioni492 – 773COX2Add BLAST282

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
cd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.10.287.90, 1 hit
1.20.210.10, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR033944 Cyt_c_oxase_su1_dom
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81442 SSF81442, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q2LCQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLEIYDKQ LVEQEEGGFR AILTRYLNKW IFTVDHKLIG TMYITFSIFA
60 70 80 90 100
GIIGTLLSLV IPMELSTGNM LEGDSQQYNV IVTAHGLIMI FFVVMYCSMP
110 120 130 140 150
AMLGGFANWF LPIMVGAPDV AFPRLNNISL WLIVVSFGLL LTSSCVGIGA
160 170 180 190 200
GTGWTVYPPL SMMEYHPGHA VDVGILSLHI AGASSLVGAI NFLTTVFNMK
210 220 230 240 250
IAGLSWPKVS LFVWSVVITA VLLVLSLPVL AGGLTMLITD RNFETTFFDP
260 270 280 290 300
IGGGDPILYQ HLFHPEVYIL ILPGFGIISI IISRYSNKGI FGVKGMISAM
310 320 330 340 350
SAIGFLGFLV WAYHHMYTVG LDVDTRAYFT AATMIIAIPT GIKIFSWLAT
360 370 380 390 400
LWGGVIKITT PMLFVIGFLV LFTIGGLTGV VLANGGLDIS LHDTYYVVAH
410 420 430 440 450
FHYVLSMGAI FAIFAGYYYY YAIMNSNRIL GIVRYNEQLG RIHFWTMFIG
460 470 480 490 500
VNVTFFPMHF LGLAGMPRRI GDYPDAYIGW NLIASYGSLI TAFGLLFFFV
510 520 530 540 550
NIFTPYFKKK ALISKKFQRG AMILMGLDFS RDWQIGFQDP ATPIMEGIID
560 570 580 590 600
LHNYIFFYLI VVAVFIGWVM GRILWRFAYK WSYPTIGDIE IFKNFTAYNQ
610 620 630 640 650
IIHGTVIEIV WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW
660 670 680 690 700
YWSYEYGDNS SNLVEFDSYM VYERDLNEGQ LRLLEVDNSM IVPVKTHIRL
710 720 730 740 750
IITSGDVLHS WAVPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV
760 770
DHGFMPIKVE AVKVQEYLGR LYK
Length:773
Mass (Da):86,778
Last modified:February 21, 2006 - v1
Checksum:iDBAB29E1527D1BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ336395 Genomic DNA Translation: ABC60387.1
RefSeqiYP_492636.2, NC_007787.2

Genome annotation databases

GeneIDi3912629

Similar proteinsi

Entry informationi

Entry nameiCOX1_DICCI
AccessioniPrimary (citable) accession number: Q2LCQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 21, 2006
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health