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Q2LCQ6

- COX1_DICCI

UniProt

Q2LCQ6 - COX1_DICCI

Protein

Cytochrome c oxidase subunit 1+2

Gene

cox1/2

Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Iron (heme A axial ligand)By similarity
    Metal bindingi264 – 2641Copper BBy similarity
    Metal bindingi268 – 2681Copper BBy similarity
    Metal bindingi314 – 3141Copper BBy similarity
    Metal bindingi315 – 3151Copper BBy similarity
    Metal bindingi400 – 4001Iron (heme A3 axial ligand)By similarity
    Metal bindingi402 – 4021Iron (heme A axial ligand)By similarity
    Metal bindingi709 – 7091Copper ABy similarity
    Metal bindingi744 – 7441Copper ABy similarity
    Metal bindingi748 – 7481Copper ABy similarity
    Metal bindingi752 – 7521Copper ABy similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I+II
    Gene namesi
    Name:cox1/2
    Encoded oniMitochondrion
    OrganismiDictyostelium citrinum (Slime mold)
    Taxonomic identifieri361072 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 773773Cytochrome c oxidase subunit 1+2PRO_0000312386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LCQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 11125HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 27817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei483 – 50321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei555 – 57521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei604 – 62421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 491491COX1Add
    BLAST
    Regioni492 – 773282COX2Add
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
    In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    1.20.210.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR000883. COX1.
    IPR008972. Cupredoxin.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81442. SSF81442. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LCQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLEIYDKQ LVEQEEGGFR AILTRYLNKW IFTVDHKLIG TMYITFSIFA    50
    GIIGTLLSLV IPMELSTGNM LEGDSQQYNV IVTAHGLIMI FFVVMYCSMP 100
    AMLGGFANWF LPIMVGAPDV AFPRLNNISL WLIVVSFGLL LTSSCVGIGA 150
    GTGWTVYPPL SMMEYHPGHA VDVGILSLHI AGASSLVGAI NFLTTVFNMK 200
    IAGLSWPKVS LFVWSVVITA VLLVLSLPVL AGGLTMLITD RNFETTFFDP 250
    IGGGDPILYQ HLFHPEVYIL ILPGFGIISI IISRYSNKGI FGVKGMISAM 300
    SAIGFLGFLV WAYHHMYTVG LDVDTRAYFT AATMIIAIPT GIKIFSWLAT 350
    LWGGVIKITT PMLFVIGFLV LFTIGGLTGV VLANGGLDIS LHDTYYVVAH 400
    FHYVLSMGAI FAIFAGYYYY YAIMNSNRIL GIVRYNEQLG RIHFWTMFIG 450
    VNVTFFPMHF LGLAGMPRRI GDYPDAYIGW NLIASYGSLI TAFGLLFFFV 500
    NIFTPYFKKK ALISKKFQRG AMILMGLDFS RDWQIGFQDP ATPIMEGIID 550
    LHNYIFFYLI VVAVFIGWVM GRILWRFAYK WSYPTIGDIE IFKNFTAYNQ 600
    IIHGTVIEIV WTLIPTVILY LIAIPSFTLL YAMDEIINPT VTIKIIGHQW 650
    YWSYEYGDNS SNLVEFDSYM VYERDLNEGQ LRLLEVDNSM IVPVKTHIRL 700
    IITSGDVLHS WAVPSFGIKV DAVPGRLNQI GLYVKREGTF YGQCSELCGV 750
    DHGFMPIKVE AVKVQEYLGR LYK 773
    Length:773
    Mass (Da):86,778
    Last modified:February 21, 2006 - v1
    Checksum:iDBAB29E1527D1BD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ336395 Genomic DNA. Translation: ABC60387.1.
    RefSeqiYP_492636.2. NC_007787.2.

    Genome annotation databases

    GeneIDi3912629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ336395 Genomic DNA. Translation: ABC60387.1 .
    RefSeqi YP_492636.2. NC_007787.2.

    3D structure databases

    ProteinModelPortali Q2LCQ6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3912629.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    1.20.210.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR000883. COX1.
    IPR008972. Cupredoxin.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81442. SSF81442. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mitochondrial genome evolution in the social amoebae."
      Heidel A.J., Gloeckner G.
      Mol. Biol. Evol. 25:1440-1450(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_DICCI
    AccessioniPrimary (citable) accession number: Q2LCQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3