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Protein

Cytochrome c oxidase subunit 3

Gene

cox3

Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox3
Encoded oniMitochondrion
OrganismiDictyostelium citrinum (Slime mold)
Taxonomic identifieri361072 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123871 – 431Cytochrome c oxidase subunit 3Add BLAST431

Structurei

3D structure databases

ProteinModelPortaliQ2LCP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 2 hits.
SUPFAMiSSF81452. SSF81452. 2 hits.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2LCP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRFFENLFS QTERSVLNTG KKVGAGIAAG EWKNTEWGYP IATQEVIFLA
60 70 80 90 100
KVFQPQHVKR HPYHIVRGTI APLAVTLPLA FFVLNYFGVI SSKIGFVIAL
110 120 130 140 150
SSFIGGLTIW AISIVFDSLY DQQHTYEVKR GLVMGMMMFI ISEIMFFFSF
160 170 180 190 200
FWSYFYISLS PNIAIGCVWP PYGLTVYSYM GLPLLNTVLL LLSGAILTDG
210 220 230 240 250
YTILTEQKAV HENNEKVIAV EEAFTNLMNL YTKKQSINTL TFVDERREKF
260 270 280 290 300
FAKNDQNAEK KEIAISAGVK ELRDLDWDLY FFENPQNMEP NYKAPTDLSV
310 320 330 340 350
IEYALITIFL KKRNKVIKTR LYFTLVCAVV FLFCQGYEYY FAPFSMNDGI
360 370 380 390 400
YGSLFFLLTG FHGFHVLVGS ILIGIITIRF IVGNFDLLNV GTKFQIFKNK
410 420 430
STGFACTLFY WHFVDIVWIF LYIVIYWWGS R
Length:431
Mass (Da):49,659
Last modified:February 21, 2006 - v1
Checksum:iCEAE1DA818BFBA3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ336395 Genomic DNA. Translation: ABC60394.1.
RefSeqiYP_492643.1. NC_007787.2.

Genome annotation databases

GeneIDi3912631.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOX3_DICCI
AccessioniPrimary (citable) accession number: Q2LCP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 21, 2006
Last modified: April 12, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families