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Q2LCP5

- NDUS1_DICCI

UniProt

Q2LCP5 - NDUS1_DICCI

Protein

NADH-ubiquinone oxidoreductase 75 kDa subunit

Gene

nad11

Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 2Fe-2S cluster per subunit.By similarity
    Binds 2 4Fe-4S clusters per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi49 – 491Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi52 – 521Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi66 – 661Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi101 – 1011Iron-sulfur 2 (4Fe-4S); via pros nitrogenBy similarity
    Metal bindingi105 – 1051Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi108 – 1081Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi114 – 1141Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi156 – 1561Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi159 – 1591Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi204 – 2041Iron-sulfur 3 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. electron carrier activity Source: InterPro
    4. metal ion binding Source: UniProtKB-KW
    5. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 75 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-75kD
    Short name:
    CI-75kD
    Gene namesi
    Name:nad11
    Synonyms:ndufs1
    Encoded oniMitochondrion
    OrganismiDictyostelium citrinum (Slime mold)
    Taxonomic identifieri361072 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

    Subcellular locationi

    Mitochondrion inner membrane By similarity
    Note: Matrix and cytoplasmic side of the mitochondrial inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 688688NADH-ubiquinone oxidoreductase 75 kDa subunitPRO_0000327378Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 45 different subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LCP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 85852Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini223 – 279574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the complex I 75 kDa subunit family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
    IPR010228. NADH_UbQ_OxRdtase_Gsu.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view]
    PfamiPF00384. Molybdopterin. 2 hits.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SMARTiSM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR01973. NuoG. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00641. COMPLEX1_75K_1. 1 hit.
    PS00642. COMPLEX1_75K_2. 1 hit.
    PS00643. COMPLEX1_75K_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LCP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIRFKINEI ECEVDEEKED LTILQACTAN GIEIPRFCYH EKLTIAGNCR    50
    MCLVYVTNEE KLLAACGIPL DENFDDESIE TEIDEILKAR EGVMEFLLIN 100
    HPLDCPICDQ GGECDLQEQT IAYGLDTGRF YIKKRAVEVK AFGRLIKGIM 150
    TRCIHCTRCV RFLTEIAGVN ELGVLGRGYN MEIGTYKKNV IIESELSGNI 200
    IDLCPVGALT SAVYAYKGRP WELKNIKGID IFDTVLTPIN YQVKGGEIFR 250
    ILPRINDRLN EEWITDKVRF HYESYKIIEK MRKDTPSYKI QANKFIELSW 300
    KTALKMVFKV LLNKKNKVDL IIGSKINSTN LRIYKELMNR LGSKNYITEN 350
    GLLFKKFNYD FRENYINSND LYNVDQNDLV LLCGINLRVE SPLLNIKLRN 400
    INFGDDEIET RKKIGIIGNK FDWKQESEYL GSTVNSMLKV FEGRFPYCQQ 450
    IKKSKAPLIL VGSSLLSRIA ISLQEIRAAF EIASNIKPEN VLLITQGANF 500
    GMALEEGIFK ENFSKGGNVL YSIDSNEYKV SKTINYIIYQ GILNDTFENK 550
    IDLYLPSKHY FEDFESDREI YVNTFGQRSE IEKLRISKGN KIKENSMIGY 600
    IQLMYLNKKE MNRKEKEQKE IKITYRGIKQ KEKRQVKINK NLTINNIIDN 650
    YYMTDINSRL SKNLMITGQL RKEKKIMEAG SWKNKTCI 688
    Length:688
    Mass (Da):79,605
    Last modified:April 8, 2008 - v2
    Checksum:iFDC7CCB227832A0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ336395 Genomic DNA. Translation: ABC60398.4.
    RefSeqiYP_003579824.1. NC_007787.2.

    Genome annotation databases

    GeneIDi9086870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ336395 Genomic DNA. Translation: ABC60398.4 .
    RefSeqi YP_003579824.1. NC_007787.2.

    3D structure databases

    ProteinModelPortali Q2LCP5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9086870.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
    IPR010228. NADH_UbQ_OxRdtase_Gsu.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view ]
    Pfami PF00384. Molybdopterin. 2 hits.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SMARTi SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR01973. NuoG. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00641. COMPLEX1_75K_1. 1 hit.
    PS00642. COMPLEX1_75K_2. 1 hit.
    PS00643. COMPLEX1_75K_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary trends found in social amoebae."
      Gloeckner G., Schaap P., Winckler T.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiNDUS1_DICCI
    AccessioniPrimary (citable) accession number: Q2LCP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3