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Q2LCP5

- NDUS1_DICCI

UniProt

Q2LCP5 - NDUS1_DICCI

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Protein
NADH-ubiquinone oxidoreductase 75 kDa subunit
Gene
nad11, ndufs1
Organism
Dictyostelium citrinum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 2Fe-2S cluster per subunit By similarity.
Binds 2 4Fe-4S clusters per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi49 – 491Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi52 – 521Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi66 – 661Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi101 – 1011Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity
Metal bindingi105 – 1051Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi108 – 1081Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi114 – 1141Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi156 – 1561Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi159 – 1591Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi204 – 2041Iron-sulfur 3 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 75 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-75kD
Short name:
CI-75kD
Gene namesi
Name:nad11
Synonyms:ndufs1
Encoded oniMitochondrion
OrganismiDictyostelium citrinum (Slime mold)
Taxonomic identifieri361072 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Subcellular locationi

Mitochondrion inner membrane By similarity
Note: Matrix and cytoplasmic side of the mitochondrial inner membrane By similarity.

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688NADH-ubiquinone oxidoreductase 75 kDa subunit
PRO_0000327378Add
BLAST

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ2LCP5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 85852Fe-2S ferredoxin-type
Add
BLAST
Domaini223 – 279574Fe-4S Mo/W bis-MGD-type
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF00384. Molybdopterin. 2 hits.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SMARTiSM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01973. NuoG. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LCP5-1 [UniParc]FASTAAdd to Basket

« Hide

MLIRFKINEI ECEVDEEKED LTILQACTAN GIEIPRFCYH EKLTIAGNCR    50
MCLVYVTNEE KLLAACGIPL DENFDDESIE TEIDEILKAR EGVMEFLLIN 100
HPLDCPICDQ GGECDLQEQT IAYGLDTGRF YIKKRAVEVK AFGRLIKGIM 150
TRCIHCTRCV RFLTEIAGVN ELGVLGRGYN MEIGTYKKNV IIESELSGNI 200
IDLCPVGALT SAVYAYKGRP WELKNIKGID IFDTVLTPIN YQVKGGEIFR 250
ILPRINDRLN EEWITDKVRF HYESYKIIEK MRKDTPSYKI QANKFIELSW 300
KTALKMVFKV LLNKKNKVDL IIGSKINSTN LRIYKELMNR LGSKNYITEN 350
GLLFKKFNYD FRENYINSND LYNVDQNDLV LLCGINLRVE SPLLNIKLRN 400
INFGDDEIET RKKIGIIGNK FDWKQESEYL GSTVNSMLKV FEGRFPYCQQ 450
IKKSKAPLIL VGSSLLSRIA ISLQEIRAAF EIASNIKPEN VLLITQGANF 500
GMALEEGIFK ENFSKGGNVL YSIDSNEYKV SKTINYIIYQ GILNDTFENK 550
IDLYLPSKHY FEDFESDREI YVNTFGQRSE IEKLRISKGN KIKENSMIGY 600
IQLMYLNKKE MNRKEKEQKE IKITYRGIKQ KEKRQVKINK NLTINNIIDN 650
YYMTDINSRL SKNLMITGQL RKEKKIMEAG SWKNKTCI 688
Length:688
Mass (Da):79,605
Last modified:April 8, 2008 - v2
Checksum:iFDC7CCB227832A0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60398.4.
RefSeqiYP_003579824.1. NC_007787.2.

Genome annotation databases

GeneIDi9086870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ336395 Genomic DNA. Translation: ABC60398.4 .
RefSeqi YP_003579824.1. NC_007787.2.

3D structure databases

ProteinModelPortali Q2LCP5.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9086870.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF00384. Molybdopterin. 2 hits.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SMARTi SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01973. NuoG. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolutionary trends found in social amoebae."
    Gloeckner G., Schaap P., Winckler T.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNDUS1_DICCI
AccessioniPrimary (citable) accession number: Q2LCP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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