Reviewed,
UniProtKB/Swiss-Prot Q2LAM0 (FA2H_RAT)
Last modified
June 16, 2009.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fatty acid 2-hydroxylase EC=1.-.-.- Alternative name(s): Fatty acid alpha-hydroxylase | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 372 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids. Ref.4 |
| Cofactor | Iron By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein By similarity. |
| Tissue specificity | Detected in oligodendrocytes (at protein level). Detected in sciatic nerve. Ref.4 Ref.3 |
| Developmental stage | Detected at low levels in sciatic nerve from newborns. Levels increase strongly during the first 3 weeks, and decrease thereafter to reach a low, constitutive level in 4 week olds. Expressed at a low, constitutive level in adults. Ref.4 |
| Induction | Up-regulated in sciatic nerve during myelination. Up-regulated in differentiating cultured Schwann cells. Ref.4 |
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Sequence similarities | Belongs to the SCS7 family. Contains 1 cytochrome b5 heme-binding domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 372 | 372 | Fatty acid 2-hydroxylase | PRO_0000312352 | |||||
Regions | |||||||||
| Transmembrane | 168 – 188 | 21 | Potential | ||||||
| Transmembrane | 213 – 233 | 21 | Potential | ||||||
| Transmembrane | 268 – 288 | 21 | Potential | ||||||
| Transmembrane | 290 – 310 | 21 | Potential | ||||||
| Domain | 8 – 86 | 79 | Cytochrome b5 heme-binding | ||||||
Sites | |||||||||
| Metal binding | 43 | 1 | Iron (heme axial ligand) By similarity | ||||||
| Metal binding | 69 | 1 | Iron (heme axial ligand) By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Molto E., Bonzon-Kulichenko E., Gallardo N., Andres A. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-347. Strain: Wistar. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-372. |
| [3] | "FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain." Alderson N.L., Maldonado E.N., Kern M.J., Bhat N.R., Hama H. J. Lipid Res. 47:2772-2780(2006) [PubMed: 16998236] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [4] | "FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin." Maldonado E.N., Alderson N.L., Monje P.V., Wood P.M., Hama H. J. Lipid Res. 49:153-161(2008) [PubMed: 17901466] [Abstract] Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| DQ339484 mRNA. Translation: ABC71132.1. CO396956 mRNA. No translation available. | |
| IPI | IPI00359657. |
| RefSeq | NP_001129055.1. |
| UniGene | Rn.67886 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000018950. Rattus norvegicus. [Contig view] |
| GeneID | 307855. |
| KEGG | rno:307855. |
| NMPDR | fig|10116.3.peg.15027. |
Organism-specific databases | |
| RGD | 1310347. Fa2h. |
Phylogenomic databases | |
| HOVERGEN | Q2LAM0. |
| OMA | Q2LAM0. NKPLLMQ. |
Gene expression databases | |
| ArrayExpress | Q2LAM0. |
Family and domain databases | |
| InterPro | IPR001199. Cyt_B5. IPR018506. Cyt_B5_heme-BS. IPR006694. Fatty_acid_hydroxylase. IPR014430. Ino-phos-ceramide-B_Hydrxlase. [Graphical view] |
| Gene3D | G3DSA:3.10.120.10. Cyt_B5. 1 hit. |
| Pfam | PF00173. Cyt-b5. 1 hit. PF04116. FA_hydroxylase. 1 hit. [Graphical view] |
| PIRSF | PIRSF005149. IPC-B_HD. 1 hit. |
| PRINTS | PR00363. CYTOCHROMEB5. |
| ProDom | PD000612. Cyt_B5. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00191. CYTOCHROME_B5_1. 1 hit. PS50255. CYTOCHROME_B5_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 658001. |
Entry information
| Entry name | FA2H_RAT | ||||||||
| Accession | Primary (citable) accession number: Q2LAM0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


