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Q2LA60

- CP21A_FELCA

UniProt

Q2LA60 - CP21A_FELCA

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Protein

Steroid 21-hydroxylase

Gene
CYP21
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Catalytic activityi

A C(21) steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 21-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi426 – 4261Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. steroid 21-monooxygenase activity Source: UniProtKB-EC
  4. steroid binding Source: UniProtKB-KW

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Lipid-binding, Metal-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 21-hydroxylase (EC:1.14.99.10)
Alternative name(s):
21-OHase
Cytochrome P-450c21
Cytochrome P450 21
Cytochrome P450 XXI
Cytochrome P450-C21
Gene namesi
Name:CYP21
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Steroid 21-hydroxylasePRO_0000269710Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000004176.

Structurei

3D structure databases

ProteinModelPortaliQ2LA60.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 35617Steroid-binding By similarityAdd
BLAST

Domaini

The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
KOiK00513.
OrthoDBiEOG7BCNBG.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LA60-1 [UniParc]FASTAAdd to Basket

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MLLLGLLLLT ALAGARLLWN KWKYRSLHLP PLAPGFLHLL QPDLPIYLLG    50
LTQKLGPVYR LRLGLQDVVV LNSKRTIEEA LIRRWVDFAG RPQMPSYKLV 100
SQHYQDLSLG DYSLLWKAHK KLTRSALLLG IRNSMEPLVE QLTQEFCERM 150
RAQAGTPVAI QKEFSFLTCS VICCLTFGDK EDTLVHAFHD CVEDLMKSWE 200
HWSIQVLDIV PFLRFFPNPG LRRLKQALEN RDRIVEKQLR QHKDSMVAGQ 250
WRDMTDYMLQ GMGKPKVEKG HGRLLEGHVH MSVVDLFIGG TETTATTLSW 300
AVAFLLHHPE IQQRLQEELD CELGPGASGS RVPLKDPSRL PLLTATIAEV 350
LRLRPVVPLA LPHRTTRHSS ILGYDIPEGT VVIPNLQGAH LDDTVWEQPH 400
EFRPDRFLVP GASPRVLAFG CGARVCLGEP LARLELFVVL ARLLHAFTLL 450
PPTGPLPSLR PRSHCGINLT MQPFQVRLQP RGAVAPGPSQ HQ 492
Length:492
Mass (Da):55,476
Last modified:February 21, 2006 - v1
Checksum:i3BFA53788469E510
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ341429 Genomic DNA. Translation: ABC69211.1.
RefSeqiXP_003986007.1. XM_003985958.2.

Genome annotation databases

GeneIDi101094596.
KEGGifca:101094596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ341429 Genomic DNA. Translation: ABC69211.1 .
RefSeqi XP_003986007.1. XM_003985958.2.

3D structure databases

ProteinModelPortali Q2LA60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000004176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101094596.
KEGGi fca:101094596.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
KOi K00513.
OrthoDBi EOG7BCNBG.
TreeFami TF105095.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic analysis of a steroid 21-hydroxylase gene in some species of animals and a man."
    Brzezinska K., Kosowska B., Dobosz T., Moska M., Strzala T., Marszalek B.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Birman.

Entry informationi

Entry nameiCP21A_FELCA
AccessioniPrimary (citable) accession number: Q2LA60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 21, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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