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Q2LA59

- CP21A_LYNLY

UniProt

Q2LA59 - CP21A_LYNLY

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Protein
Steroid 21-hydroxylase
Gene
CYP21
Organism
Lynx lynx (Eurasian lynx) (Felis lynx)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Catalytic activityi

A C(21) steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 21-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi426 – 4261Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. steroid 21-monooxygenase activity Source: UniProtKB-EC
  4. steroid binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Lipid-binding, Metal-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 21-hydroxylase (EC:1.14.99.10)
Alternative name(s):
21-OHase
Cytochrome P-450c21
Cytochrome P450 21
Cytochrome P450 XXI
Cytochrome P450-C21
Gene namesi
Name:CYP21
OrganismiLynx lynx (Eurasian lynx) (Felis lynx)
Taxonomic identifieri13125 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeLynx

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Steroid 21-hydroxylase
PRO_0000269711Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2LA59.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 35617Steroid-binding By similarity
Add
BLAST

Domaini

The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2LA59-1 [UniParc]FASTAAdd to Basket

« Hide

MLLLGLLLLT ALAGARLLWN KWKYRSLHLP PLAPGFLHLL QPDLPIYLLG    50
LTQKLGPVYR LRLGLQDVVV LNSKRTIEEA MIRRWVDFAG RPQMPSYKLV 100
SQPYQDLSLG DYSLLWKAHK KLTRSALLLG IRNSMEPLVE QLTQEFCERM 150
RAQAGTPVAI QKEFSFLTCS VICCLTFGDK EDTLVHAFHD CVQDLMKSWE 200
HWSIQVLDIV PFLRFFPNPG LQRLKQALEN RDRIVEKQLR QHKDSMVAGQ 250
WRDMTDYMLQ GMGKPRAEKG HGRLLEGHVH MSVVDLFIGG TETTATTLSW 300
AVAFLLHHPE IQQRLQEELD CELGPGASGS RVPLKDPSRL PLLTATIAEV 350
LRLRPVVPLA LPHRTTRHSS ILGYDIPEGT VVIPNLQGAH LDDTVWEQPH 400
EFRPDRFLVP GASPRVLAFG CGARVCLGEP LARLELFVVL ARLLHAFTLL 450
PPTGPLPSLR PRSHCGINLT MQPFQVQLQP RGAVAPGPSQ HQ 492
Length:492
Mass (Da):55,397
Last modified:February 21, 2006 - v1
Checksum:iAA148E9CB122C05D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ341430 Genomic DNA. Translation: ABC69212.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ341430 Genomic DNA. Translation: ABC69212.1 .

3D structure databases

ProteinModelPortali Q2LA59.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic analysis of a steroid 21-hydroxylase gene in some species of animals and a man."
    Kosowska B., Brzezinska K., Dobosz T., Moska M., Strzala T., Marszalek B., Schmidt K.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.

Entry informationi

Entry nameiCP21A_LYNLY
AccessioniPrimary (citable) accession number: Q2LA59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 21, 2006
Last modified: December 11, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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