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Q2LA59

- CP21A_LYNLY

UniProt

Q2LA59 - CP21A_LYNLY

Protein

Steroid 21-hydroxylase

Gene

CYP21

Organism
Lynx lynx (Eurasian lynx) (Felis lynx)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

    Catalytic activityi

    A C(21) steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 21-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi426 – 4261Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. steroid 21-monooxygenase activity Source: UniProtKB-EC
    4. steroid binding Source: UniProtKB-KW

    GO - Biological processi

    1. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Lipid-binding, Metal-binding, Steroid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid 21-hydroxylase (EC:1.14.99.10)
    Alternative name(s):
    21-OHase
    Cytochrome P-450c21
    Cytochrome P450 21
    Cytochrome P450 XXI
    Cytochrome P450-C21
    Gene namesi
    Name:CYP21
    OrganismiLynx lynx (Eurasian lynx) (Felis lynx)
    Taxonomic identifieri13125 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeLynx

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Steroid 21-hydroxylasePRO_0000269711Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ2LA59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni340 – 35617Steroid-bindingBy similarityAdd
    BLAST

    Domaini

    The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane.

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2LA59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLGLLLLT ALAGARLLWN KWKYRSLHLP PLAPGFLHLL QPDLPIYLLG    50
    LTQKLGPVYR LRLGLQDVVV LNSKRTIEEA MIRRWVDFAG RPQMPSYKLV 100
    SQPYQDLSLG DYSLLWKAHK KLTRSALLLG IRNSMEPLVE QLTQEFCERM 150
    RAQAGTPVAI QKEFSFLTCS VICCLTFGDK EDTLVHAFHD CVQDLMKSWE 200
    HWSIQVLDIV PFLRFFPNPG LQRLKQALEN RDRIVEKQLR QHKDSMVAGQ 250
    WRDMTDYMLQ GMGKPRAEKG HGRLLEGHVH MSVVDLFIGG TETTATTLSW 300
    AVAFLLHHPE IQQRLQEELD CELGPGASGS RVPLKDPSRL PLLTATIAEV 350
    LRLRPVVPLA LPHRTTRHSS ILGYDIPEGT VVIPNLQGAH LDDTVWEQPH 400
    EFRPDRFLVP GASPRVLAFG CGARVCLGEP LARLELFVVL ARLLHAFTLL 450
    PPTGPLPSLR PRSHCGINLT MQPFQVQLQP RGAVAPGPSQ HQ 492
    Length:492
    Mass (Da):55,397
    Last modified:February 21, 2006 - v1
    Checksum:iAA148E9CB122C05D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ341430 Genomic DNA. Translation: ABC69212.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ341430 Genomic DNA. Translation: ABC69212.1 .

    3D structure databases

    ProteinModelPortali Q2LA59.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic analysis of a steroid 21-hydroxylase gene in some species of animals and a man."
      Kosowska B., Brzezinska K., Dobosz T., Moska M., Strzala T., Marszalek B., Schmidt K.
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiCP21A_LYNLY
    AccessioniPrimary (citable) accession number: Q2LA59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3