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Q2L6L1

- CNPY1_DANRE

UniProt

Q2L6L1 - CNPY1_DANRE

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Protein

Protein canopy-1

Gene

cnpy1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development.1 Publication

GO - Biological processi

  1. determination of left/right symmetry Source: ZFIN
  2. fibroblast growth factor receptor signaling pathway Source: ZFIN
  3. Kupffer's vesicle development Source: ZFIN
  4. midbrain-hindbrain boundary development Source: ZFIN
  5. regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy-1
Alternative name(s):
Protein D121
Gene namesi
Name:cnpy1
Synonyms:d121
ORF Names:si:dkey-265a7.3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-060315-3. cnpy1.

Subcellular locationi

Endoplasmic reticulum 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi184 – 1874HSEL → KDEL: Does not abolish endoplasmic reticulum localization. 1 Publication
Mutagenesisi184 – 1874Missing: Abolishes endoplasmic reticulum localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 187163Protein canopy-1PRO_0000314013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 177By similarity
Disulfide bondi35 ↔ 170By similarity
Disulfide bondi90 ↔ 143By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed maternally from early cleavage stages until the shield stage. Expressed zygotically in the polster at the bud stage. Expressed in the midbrain-hindbrain boundary (MHB) at 12 hours post-fertilization (hpf). Expressed in the tail bud and the mesenchymal cells of the caudal fin primordia at 26 hpf.1 Publication

Inductioni

By the fibroblast growth factor fgf8 in the MHB.1 Publication

Gene expression databases

BgeeiQ2L6L1.

Interactioni

Subunit structurei

Homodimer. Interacts with fgfr1.1 Publication

Protein-protein interaction databases

STRINGi7955.ENSDARP00000009432.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 181154Saposin B-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi184 – 1874Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the canopy family.Curated
Contains 1 saposin B-type domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280279.
GeneTreeiENSGT00390000009749.
HOGENOMiHOG000233996.
HOVERGENiHBG052514.
InParanoidiQ2L6L1.
OMAiDELNYSI.
OrthoDBiEOG7XDBHB.
PhylomeDBiQ2L6L1.
TreeFamiTF318578.

Family and domain databases

InterProiIPR021852. DUF3456.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2L6L1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPWIKHICL VLVAAFMLVK TTESKKDEAL YCSACMAIAD EINYSISQTD
60 70 80 90 100
PKKMIHVGGF RLKPDGSLTD KKVPLARSET YLTELLEEVC KSMSDYALYE
110 120 130 140 150
NPDTKEKSYK RFAPRDNDGG NFPDFKNFKF DGPESSSALK FACESIVEEL
160 170 180
EDDIISLFAS DSDHVAKTLC SEVSDHCKSS VFQHSEL
Length:187
Mass (Da):20,973
Last modified:March 7, 2006 - v1
Checksum:iBA9147D3A4BB47E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB201383 mRNA. Translation: BAE78824.1.
BX510360 Genomic DNA. Translation: CAM46989.1.
BC122425 mRNA. Translation: AAI22426.1.
AB055671 mRNA. Translation: BAB62803.1.
RefSeqiNP_001034586.1. NM_001039497.2.
UniGeneiDr.107959.

Genome annotation databases

EnsembliENSDART00000020792; ENSDARP00000009432; ENSDARG00000003757.
GeneIDi402819.
KEGGidre:402819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB201383 mRNA. Translation: BAE78824.1 .
BX510360 Genomic DNA. Translation: CAM46989.1 .
BC122425 mRNA. Translation: AAI22426.1 .
AB055671 mRNA. Translation: BAB62803.1 .
RefSeqi NP_001034586.1. NM_001039497.2.
UniGenei Dr.107959.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000009432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000020792 ; ENSDARP00000009432 ; ENSDARG00000003757 .
GeneIDi 402819.
KEGGi dre:402819.

Organism-specific databases

CTDi 285888.
ZFINi ZDB-GENE-060315-3. cnpy1.

Phylogenomic databases

eggNOGi NOG280279.
GeneTreei ENSGT00390000009749.
HOGENOMi HOG000233996.
HOVERGENi HBG052514.
InParanoidi Q2L6L1.
OMAi DELNYSI.
OrthoDBi EOG7XDBHB.
PhylomeDBi Q2L6L1.
TreeFami TF318578.

Miscellaneous databases

NextBioi 20816648.
PROi Q2L6L1.

Gene expression databases

Bgeei Q2L6L1.

Family and domain databases

InterProi IPR021852. DUF3456.
[Graphical view ]
Pfami PF11938. DUF3456. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish."
    Hirate Y., Okamoto H.
    Curr. Biol. 16:421-427(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, INTERACTION WITH FGFR1, INDUCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF 184-HIS--LEU-187, DEVELOPMENTAL STAGE.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "A systematic search for the downstream target genes of the midbrain-MHB reciprocal inductive signaling by ordered differential display revealed the expression of ephrin-A3 in the posterior tectum of zebrafish embryos."
    Hirate Y., Mieda M., Harada T., Yamasu K., Okamoto H.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-187.

Entry informationi

Entry nameiCNPY1_DANRE
AccessioniPrimary (citable) accession number: Q2L6L1
Secondary accession number(s): Q90ZG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3