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Q2L6L1

- CNPY1_DANRE

UniProt

Q2L6L1 - CNPY1_DANRE

Protein

Protein canopy-1

Gene

cnpy1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development.1 Publication

    GO - Biological processi

    1. determination of left/right symmetry Source: ZFIN
    2. fibroblast growth factor receptor signaling pathway Source: ZFIN
    3. Kupffer's vesicle development Source: ZFIN
    4. midbrain-hindbrain boundary development Source: ZFIN
    5. regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein canopy-1
    Alternative name(s):
    Protein D121
    Gene namesi
    Name:cnpy1
    Synonyms:d121
    ORF Names:si:dkey-265a7.3
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 2

    Organism-specific databases

    ZFINiZDB-GENE-060315-3. cnpy1.

    Subcellular locationi

    Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ZFIN

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi184 – 1874HSEL → KDEL: Does not abolish endoplasmic reticulum localization. 1 Publication
    Mutagenesisi184 – 1874Missing: Abolishes endoplasmic reticulum localization. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 187163Protein canopy-1PRO_0000314013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 177By similarity
    Disulfide bondi35 ↔ 170By similarity
    Disulfide bondi90 ↔ 143By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Developmental stagei

    Expressed maternally from early cleavage stages until the shield stage. Expressed zygotically in the polster at the bud stage. Expressed in the midbrain-hindbrain boundary (MHB) at 12 hours post-fertilization (hpf). Expressed in the tail bud and the mesenchymal cells of the caudal fin primordia at 26 hpf.1 Publication

    Inductioni

    By the fibroblast growth factor fgf8 in the MHB.1 Publication

    Gene expression databases

    BgeeiQ2L6L1.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with fgfr1.1 Publication

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000009432.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 181154Saposin B-typeAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi184 – 1874Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the canopy family.Curated
    Contains 1 saposin B-type domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280279.
    GeneTreeiENSGT00390000009749.
    HOGENOMiHOG000233996.
    HOVERGENiHBG052514.
    OMAiDELNYSI.
    OrthoDBiEOG7XDBHB.
    PhylomeDBiQ2L6L1.
    TreeFamiTF318578.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    [Graphical view]
    PfamiPF11938. DUF3456. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2L6L1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPWIKHICL VLVAAFMLVK TTESKKDEAL YCSACMAIAD EINYSISQTD    50
    PKKMIHVGGF RLKPDGSLTD KKVPLARSET YLTELLEEVC KSMSDYALYE 100
    NPDTKEKSYK RFAPRDNDGG NFPDFKNFKF DGPESSSALK FACESIVEEL 150
    EDDIISLFAS DSDHVAKTLC SEVSDHCKSS VFQHSEL 187
    Length:187
    Mass (Da):20,973
    Last modified:March 7, 2006 - v1
    Checksum:iBA9147D3A4BB47E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB201383 mRNA. Translation: BAE78824.1.
    BX510360 Genomic DNA. Translation: CAM46989.1.
    BC122425 mRNA. Translation: AAI22426.1.
    AB055671 mRNA. Translation: BAB62803.1.
    RefSeqiNP_001034586.1. NM_001039497.2.
    UniGeneiDr.107959.

    Genome annotation databases

    EnsembliENSDART00000020792; ENSDARP00000009432; ENSDARG00000003757.
    GeneIDi402819.
    KEGGidre:402819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB201383 mRNA. Translation: BAE78824.1 .
    BX510360 Genomic DNA. Translation: CAM46989.1 .
    BC122425 mRNA. Translation: AAI22426.1 .
    AB055671 mRNA. Translation: BAB62803.1 .
    RefSeqi NP_001034586.1. NM_001039497.2.
    UniGenei Dr.107959.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000009432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000020792 ; ENSDARP00000009432 ; ENSDARG00000003757 .
    GeneIDi 402819.
    KEGGi dre:402819.

    Organism-specific databases

    CTDi 285888.
    ZFINi ZDB-GENE-060315-3. cnpy1.

    Phylogenomic databases

    eggNOGi NOG280279.
    GeneTreei ENSGT00390000009749.
    HOGENOMi HOG000233996.
    HOVERGENi HBG052514.
    OMAi DELNYSI.
    OrthoDBi EOG7XDBHB.
    PhylomeDBi Q2L6L1.
    TreeFami TF318578.

    Miscellaneous databases

    NextBioi 20816648.
    PROi Q2L6L1.

    Gene expression databases

    Bgeei Q2L6L1.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    [Graphical view ]
    Pfami PF11938. DUF3456. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish."
      Hirate Y., Okamoto H.
      Curr. Biol. 16:421-427(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, INTERACTION WITH FGFR1, INDUCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF 184-HIS--LEU-187, DEVELOPMENTAL STAGE.
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. "A systematic search for the downstream target genes of the midbrain-MHB reciprocal inductive signaling by ordered differential display revealed the expression of ephrin-A3 in the posterior tectum of zebrafish embryos."
      Hirate Y., Mieda M., Harada T., Yamasu K., Okamoto H.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-187.

    Entry informationi

    Entry nameiCNPY1_DANRE
    AccessioniPrimary (citable) accession number: Q2L6L1
    Secondary accession number(s): Q90ZG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3