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Protein

DNA-directed RNA polymerase subunit

Gene

ZNRD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation
Gene namesi
Name:ZNRD1Imported
ORF Names:hCG_23775Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000066379.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37754

Expressioni

Gene expression databases

BgeeiENSG00000066379
ExpressionAtlasiQ2L6J2 baseline and differential

Structurei

3D structure databases

SMRiQ2L6J2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 123TFIIS-typeInterPro annotationAdd BLAST41

Sequence similaritiesi

Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2907 Eukaryota
COG1594 LUCA
HOVERGENiHBG055084
KOiK03000
OMAiVFYTCTS
OrthoDBiEOG091G0V6T

Family and domain databases

CDDicd10507 Zn-ribbon_RPA12, 1 hit
InterProiView protein in InterPro
IPR019761 DNA-dir_RNA_pol-M_15_CS
IPR012164 Rpa12/Rpb9/Rpc10/TFS
IPR034004 Zn_ribbon_RPA12_C
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF01096 TFIIS_C, 1 hit
PIRSFiPIRSF005586 RNApol_RpoM, 1 hit
SMARTiView protein in SMART
SM00440 ZnF_C2C2, 1 hit
PROSITEiView protein in PROSITE
PS01030 RNA_POL_M_15KD, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2L6J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF
60 70 80 90 100
EGKVVKTSVV FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR
110 120
QMRSADEGQT VFYTCTNCKF QEKEDS
Length:126
Mass (Da):13,904
Last modified:March 7, 2006 - v1
Checksum:iC678AC7132A91432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY500768 Genomic DNA Translation: AQY77238.1
KY500769 Genomic DNA Translation: AQY77239.1
AB202082 Genomic DNA Translation: BAE78600.1
CH471081 Genomic DNA Translation: EAX03250.1
CH471081 Genomic DNA Translation: EAX03251.1
CH471081 Genomic DNA Translation: EAX03252.1
RefSeqiNP_001265714.1, NM_001278785.1
NP_001265715.1, NM_001278786.1
NP_055411.1, NM_014596.5
NP_740753.1, NM_170783.3
UniGeneiHs.57813

Genome annotation databases

GeneIDi30834
KEGGihsa:30834

Similar proteinsi

Entry informationi

Entry nameiQ2L6J2_HUMAN
AccessioniPrimary (citable) accession number: Q2L6J2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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