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Protein

DNA-directed RNA polymerase subunit

Gene

ZNRD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation
Gene namesi
Name:ZNRD1Imported
ORF Names:hCG_23775Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleusnucleolus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37754.

Expressioni

Gene expression databases

BgeeiENSG00000066379.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331111.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 123TFIIS-typeInterPro annotationAdd BLAST41

Sequence similaritiesi

Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2907. Eukaryota.
COG1594. LUCA.
HOVERGENiHBG055084.
KOiK03000.
OMAiCYNCKQE.
OrthoDBiEOG091G0V6T.

Family and domain databases

InterProiIPR019761. DNA-dir_RNA_pol-M_15_CS.
IPR012164. Rpa12/Rpb9/Rpc10/TFS.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamiPF01096. TFIIS_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005586. RNApol_RpoM. 1 hit.
SMARTiSM00440. ZnF_C2C2. 1 hit.
[Graphical view]
PROSITEiPS01030. RNA_POL_M_15KD. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2L6J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF
60 70 80 90 100
EGKVVKTSVV FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR
110 120
QMRSADEGQT VFYTCTNCKF QEKEDS
Length:126
Mass (Da):13,904
Last modified:March 7, 2006 - v1
Checksum:iC678AC7132A91432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB202082 Genomic DNA. Translation: BAE78600.1.
CH471081 Genomic DNA. Translation: EAX03250.1.
CH471081 Genomic DNA. Translation: EAX03251.1.
CH471081 Genomic DNA. Translation: EAX03252.1.
RefSeqiNP_001265714.1. NM_001278785.1.
NP_001265715.1. NM_001278786.1.
NP_055411.1. NM_014596.5.
NP_740753.1. NM_170783.3.
UniGeneiHs.57813.

Genome annotation databases

GeneIDi30834.
KEGGihsa:30834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB202082 Genomic DNA. Translation: BAE78600.1.
CH471081 Genomic DNA. Translation: EAX03250.1.
CH471081 Genomic DNA. Translation: EAX03251.1.
CH471081 Genomic DNA. Translation: EAX03252.1.
RefSeqiNP_001265714.1. NM_001278785.1.
NP_001265715.1. NM_001278786.1.
NP_055411.1. NM_014596.5.
NP_740753.1. NM_170783.3.
UniGeneiHs.57813.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331111.

Protocols and materials databases

DNASUi30834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30834.
KEGGihsa:30834.

Organism-specific databases

CTDi30834.
PharmGKBiPA37754.

Phylogenomic databases

eggNOGiKOG2907. Eukaryota.
COG1594. LUCA.
HOVERGENiHBG055084.
KOiK03000.
OMAiCYNCKQE.
OrthoDBiEOG091G0V6T.

Miscellaneous databases

GenomeRNAii30834.

Gene expression databases

BgeeiENSG00000066379.

Family and domain databases

InterProiIPR019761. DNA-dir_RNA_pol-M_15_CS.
IPR012164. Rpa12/Rpb9/Rpc10/TFS.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamiPF01096. TFIIS_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005586. RNApol_RpoM. 1 hit.
SMARTiSM00440. ZnF_C2C2. 1 hit.
[Graphical view]
PROSITEiPS01030. RNA_POL_M_15KD. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ2L6J2_HUMAN
AccessioniPrimary (citable) accession number: Q2L6J2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.