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Protein

DNA-directed RNA polymerase subunit

Gene

ZNRD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation
Gene namesi
Name:ZNRD1Imported
ORF Names:hCG_23775Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleusnucleolus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37754.

Expressioni

Gene expression databases

BgeeiENSG00000066379.
ExpressionAtlasiQ2L6J2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331111.

Structurei

3D structure databases

ProteinModelPortaliQ2L6J2.
SMRiQ2L6J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 123TFIIS-typeInterPro annotationAdd BLAST41

Sequence similaritiesi

Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2907. Eukaryota.
COG1594. LUCA.
HOVERGENiHBG055084.
KOiK03000.
OMAiCYNCKQE.
OrthoDBiEOG091G0V6T.
PhylomeDBiQ2L6J2.

Family and domain databases

CDDicd10507. Zn-ribbon_RPA12. 1 hit.
InterProiView protein in InterPro
IPR019761. DNA-dir_RNA_pol-M_15_CS.
IPR012164. Rpa12/Rpb9/Rpc10/TFS.
IPR034004. Zn_ribbon_RPA12_C.
IPR001222. Znf_TFIIS.
PfamiView protein in Pfam
PF01096. TFIIS_C. 1 hit.
PIRSFiPIRSF005586. RNApol_RpoM. 1 hit.
SMARTiView protein in SMART
SM00440. ZnF_C2C2. 1 hit.
PROSITEiView protein in PROSITE
PS01030. RNA_POL_M_15KD. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2L6J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF
60 70 80 90 100
EGKVVKTSVV FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR
110 120
QMRSADEGQT VFYTCTNCKF QEKEDS
Length:126
Mass (Da):13,904
Last modified:March 7, 2006 - v1
Checksum:iC678AC7132A91432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB202082 Genomic DNA. Translation: BAE78600.1.
CH471081 Genomic DNA. Translation: EAX03250.1.
CH471081 Genomic DNA. Translation: EAX03251.1.
CH471081 Genomic DNA. Translation: EAX03252.1.
RefSeqiNP_001265714.1. NM_001278785.1.
NP_001265715.1. NM_001278786.1.
NP_055411.1. NM_014596.5.
NP_740753.1. NM_170783.3.
UniGeneiHs.57813.

Genome annotation databases

GeneIDi30834.
KEGGihsa:30834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB202082 Genomic DNA. Translation: BAE78600.1.
CH471081 Genomic DNA. Translation: EAX03250.1.
CH471081 Genomic DNA. Translation: EAX03251.1.
CH471081 Genomic DNA. Translation: EAX03252.1.
RefSeqiNP_001265714.1. NM_001278785.1.
NP_001265715.1. NM_001278786.1.
NP_055411.1. NM_014596.5.
NP_740753.1. NM_170783.3.
UniGeneiHs.57813.

3D structure databases

ProteinModelPortaliQ2L6J2.
SMRiQ2L6J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331111.

Protocols and materials databases

DNASUi30834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30834.
KEGGihsa:30834.

Organism-specific databases

CTDi30834.
PharmGKBiPA37754.

Phylogenomic databases

eggNOGiKOG2907. Eukaryota.
COG1594. LUCA.
HOVERGENiHBG055084.
KOiK03000.
OMAiCYNCKQE.
OrthoDBiEOG091G0V6T.
PhylomeDBiQ2L6J2.

Miscellaneous databases

GenomeRNAii30834.

Gene expression databases

BgeeiENSG00000066379.
ExpressionAtlasiQ2L6J2. baseline and differential.

Family and domain databases

CDDicd10507. Zn-ribbon_RPA12. 1 hit.
InterProiView protein in InterPro
IPR019761. DNA-dir_RNA_pol-M_15_CS.
IPR012164. Rpa12/Rpb9/Rpc10/TFS.
IPR034004. Zn_ribbon_RPA12_C.
IPR001222. Znf_TFIIS.
PfamiView protein in Pfam
PF01096. TFIIS_C. 1 hit.
PIRSFiPIRSF005586. RNApol_RpoM. 1 hit.
SMARTiView protein in SMART
SM00440. ZnF_C2C2. 1 hit.
PROSITEiView protein in PROSITE
PS01030. RNA_POL_M_15KD. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ2L6J2_HUMAN
AccessioniPrimary (citable) accession number: Q2L6J2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: April 12, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.