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Protein

DNA-directed RNA polymerase subunit

Gene

ZNRD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation
Gene namesi
Name:ZNRD1Imported
ORF Names:hCG_23775Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000066379.14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37754.

Expressioni

Gene expression databases

BgeeiENSG00000066379.

Structurei

3D structure databases

SMRiQ2L6J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 123TFIIS-typeInterPro annotationAdd BLAST41

Sequence similaritiesi

Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri83 – 123TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2907. Eukaryota.
COG1594. LUCA.
HOVERGENiHBG055084.
KOiK03000.
OMAiVFYTCTS.
OrthoDBiEOG091G0V6T.

Family and domain databases

CDDicd10507. Zn-ribbon_RPA12. 1 hit.
InterProiView protein in InterPro
IPR019761. DNA-dir_RNA_pol-M_15_CS.
IPR012164. Rpa12/Rpb9/Rpc10/TFS.
IPR034004. Zn_ribbon_RPA12_C.
IPR001222. Znf_TFIIS.
PfamiView protein in Pfam
PF01096. TFIIS_C. 1 hit.
PIRSFiPIRSF005586. RNApol_RpoM. 1 hit.
SMARTiView protein in SMART
SM00440. ZnF_C2C2. 1 hit.
PROSITEiView protein in PROSITE
PS01030. RNA_POL_M_15KD. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2L6J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF
60 70 80 90 100
EGKVVKTSVV FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR
110 120
QMRSADEGQT VFYTCTNCKF QEKEDS
Length:126
Mass (Da):13,904
Last modified:March 7, 2006 - v1
Checksum:iC678AC7132A91432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY500768 Genomic DNA. Translation: AQY77238.1.
KY500769 Genomic DNA. Translation: AQY77239.1.
AB202082 Genomic DNA. Translation: BAE78600.1.
CH471081 Genomic DNA. Translation: EAX03250.1.
CH471081 Genomic DNA. Translation: EAX03251.1.
CH471081 Genomic DNA. Translation: EAX03252.1.
RefSeqiNP_001265714.1. NM_001278785.1.
NP_001265715.1. NM_001278786.1.
NP_055411.1. NM_014596.5.
NP_740753.1. NM_170783.3.
UniGeneiHs.57813.

Genome annotation databases

GeneIDi30834.
KEGGihsa:30834.

Similar proteinsi

Entry informationi

Entry nameiQ2L6J2_HUMAN
AccessioniPrimary (citable) accession number: Q2L6J2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.