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Protein

Paired box protein Pax-9

Gene

Pax9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-9
Gene namesi
Name:Pax9Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560838 Pax9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444871 – 342Paired box protein Pax-9Add BLAST342

Proteomic databases

PaxDbiQ2L4T2
PRIDEiQ2L4T2

PTM databases

iPTMnetiQ2L4T2
PhosphoSitePlusiQ2L4T2

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011802

Structurei

3D structure databases

ProteinModelPortaliQ2L4T2
SMRiQ2L4T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 130PairedPROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 189Interaction with KDM5BBy similarityAdd BLAST22

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3517 Eukaryota
ENOG4111FI9 LUCA
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiQ2L4T2
KOiK09382
PhylomeDBiQ2L4T2
TreeFamiTF315397

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR033204 PAX9
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR24329:SF297 PTHR24329:SF297, 1 hit
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2L4T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH
60 70 80 90 100
GCVSKILARY NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW
110 120 130 140 150
EIRDRLLADG VCDKYNVPSV SSISRILRNK IGNLAQQGHY DSYKQHQPAP
160 170 180 190 200
QPALPYNHIY SYPSPITAAA AKVPTPPGVP AIPGSVALPR TWPSSHSVTD
210 220 230 240 250
ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFSAAAPH AVNGLEKGAL
260 270 280 290 300
EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG
310 320 330 340
HGWQHAGSTP LSPHNCDIPT SLAFKGMQAA REGSHSVAAS AL
Length:342
Mass (Da):36,379
Last modified:March 7, 2006 - v1
Checksum:i772255DC090D41A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB248957 mRNA Translation: BAE79272.1
RefSeqiNP_001034628.1, NM_001039539.1
UniGeneiRn.82416

Genome annotation databases

GeneIDi362741
KEGGirno:362741
UCSCiRGD:1560838 rat

Similar proteinsi

Entry informationi

Entry nameiPAX9_RAT
AccessioniPrimary (citable) accession number: Q2L4T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health