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Protein

Paired box protein Pax-9

Gene

Pax9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-9
Gene namesi
Name:Pax9Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560838. Pax9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Paired box protein Pax-9PRO_0000244487Add
BLAST

Proteomic databases

PaxDbiQ2L4T2.
PRIDEiQ2L4T2.

PTM databases

PhosphoSiteiQ2L4T2.

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011802.

Structurei

3D structure databases

ProteinModelPortaliQ2L4T2.
SMRiQ2L4T2. Positions 8-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 130127PairedPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 18922Interaction with KDM5BBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3517. Eukaryota.
ENOG4111FI9. LUCA.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiQ2L4T2.
KOiK09382.
OrthoDBiEOG79KPH3.
PhylomeDBiQ2L4T2.
TreeFamiTF315397.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033204. PAX9.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF297. PTHR24329:SF297. 1 hit.
PfamiPF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2L4T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH
60 70 80 90 100
GCVSKILARY NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW
110 120 130 140 150
EIRDRLLADG VCDKYNVPSV SSISRILRNK IGNLAQQGHY DSYKQHQPAP
160 170 180 190 200
QPALPYNHIY SYPSPITAAA AKVPTPPGVP AIPGSVALPR TWPSSHSVTD
210 220 230 240 250
ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFSAAAPH AVNGLEKGAL
260 270 280 290 300
EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG
310 320 330 340
HGWQHAGSTP LSPHNCDIPT SLAFKGMQAA REGSHSVAAS AL
Length:342
Mass (Da):36,379
Last modified:March 7, 2006 - v1
Checksum:i772255DC090D41A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB248957 mRNA. Translation: BAE79272.1.
RefSeqiNP_001034628.1. NM_001039539.1.
UniGeneiRn.82416.

Genome annotation databases

GeneIDi362741.
KEGGirno:362741.
UCSCiRGD:1560838. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB248957 mRNA. Translation: BAE79272.1.
RefSeqiNP_001034628.1. NM_001039539.1.
UniGeneiRn.82416.

3D structure databases

ProteinModelPortaliQ2L4T2.
SMRiQ2L4T2. Positions 8-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011802.

PTM databases

PhosphoSiteiQ2L4T2.

Proteomic databases

PaxDbiQ2L4T2.
PRIDEiQ2L4T2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362741.
KEGGirno:362741.
UCSCiRGD:1560838. rat.

Organism-specific databases

CTDi5083.
RGDi1560838. Pax9.

Phylogenomic databases

eggNOGiKOG3517. Eukaryota.
ENOG4111FI9. LUCA.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiQ2L4T2.
KOiK09382.
OrthoDBiEOG79KPH3.
PhylomeDBiQ2L4T2.
TreeFamiTF315397.

Miscellaneous databases

NextBioi681085.
PROiQ2L4T2.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR033204. PAX9.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR24329:SF297. PTHR24329:SF297. 1 hit.
PfamiPF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Paired box protein 9 isolated from rat thyroid."
    Katagiri N., Suzuki M.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: WistarImported.
    Tissue: ThyroidImported.

Entry informationi

Entry nameiPAX9_RAT
AccessioniPrimary (citable) accession number: Q2L4T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.