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Protein

Polypeptide N-acetylgalactosaminyltransferase

Gene

GALNT19

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Mn2+UniRule annotationSAAS annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotation, Transferase
LigandLectinUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

Names & Taxonomyi

Protein namesi
Recommended name:
Polypeptide N-acetylgalactosaminyltransferaseUniRule annotation (EC:2.4.1.-UniRule annotation)
Alternative name(s):
Protein-UDP acetylgalactosaminyltransferaseUniRule annotation
Gene namesi
Name:GALNT19Imported
Synonyms:WBSCR17Imported
ORF Names:hCG_19354Imported, tcag7.519Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000185274.11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatusUniRule annotationSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38124.

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000185274.
ExpressionAtlasiQ2L4S5. baseline and differential.

Structurei

3D structure databases

SMRiQ2L4S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini465 – 594Ricin B-type lectinInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG3736. Eukaryota.
ENOG410XPMK. LUCA.
HOVERGENiHBG051699.
KOiK00710.
OMAiNWELWCM.
OrthoDBiEOG091G03F2.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
PfamiView protein in Pfam
PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
SMARTiView protein in SMART
SM00458. RICIN. 1 hit.
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEiView protein in PROSITE
PS50231. RICIN_B_LECTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2L4S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRRVKVL LVLNLIAVAG FVLFLAKCRP IAVRSGDAFH EIRPRAEVAN
60 70 80 90 100
LSAHSASPIQ DAVLKRLSLL EDIVYRQLNG LSKSLGLIEG YGGRGKGGLP
110 120 130 140 150
ATLSPAEEEK AKGPHEKYGY NSYLSEKISL DRSIPDYRPT KCKELKYSKD
160 170 180 190 200
LPQISIIFIF VNEALSVILR SVHSAVNHTP THLLKEIILV DDNSDEEELK
210 220 230 240 250
VPLEEYVHKR YPGLVKVVRN QKREGLIRAR IEGWKVATGQ VTGFFDAHVE
260 270 280 290 300
FTAGWAEPVL SRIQENRKRV ILPSIDNIKQ DNFEVQRYEN SAHGYSWELW
310 320 330 340 350
CMYISPPKDW WDAGDPSLPI RTPAMIGCSF VVNRKFFGEI GLLDPGMDVY
360 370 380 390 400
GGENIELGIK VWLCGGSMEV LPCSRVAHIE RKKKPYNSNI GFYTKRNALR
410 420 430 440 450
VAEVWMDDYK SHVYIAWNLP LENPGIDIGD VSERRALRKS LKCKNFQWYL
460 470 480 490 500
DHVYPEMRRY NNTVAYGELR NNKAKDVCLD QGPLENHTAI LYPCHGWGPQ
510 520 530 540 550
LARYTKEGFL HLGALGTTTL LPDTRCLVDN SKSRLPQLLD CDKVKSSLYK
560 570 580 590
RWNFIQNGAI MNKGTGRCLE VENRGLAGID LILRSCTGQR WTIKNSIK
Length:598
Mass (Da):67,751
Last modified:March 7, 2006 - v1
Checksum:i9E2D52DBFBD907B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290036 mRNA. Translation: BAF82725.1.
AJ626726 mRNA. Translation: CAF25037.1.
CH236952 Genomic DNA. Translation: EAL23969.1.
CH471140 Genomic DNA. Translation: EAX07900.1.
RefSeqiNP_071924.1. NM_022479.2.
UniGeneiHs.488591.

Genome annotation databases

GeneIDi64409.
KEGGihsa:64409.

Similar proteinsi

Entry informationi

Entry nameiQ2L4S5_HUMAN
AccessioniPrimary (citable) accession number: Q2L4S5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.