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Protein

Serine protease 53

Gene

PRSS53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei77Charge relay systemBy similarity1
Active sitei128Charge relay systemBy similarity1
Active sitei224Charge relay systemBy similarity1
Active sitei341Charge relay systemBy similarity1
Active sitei382Charge relay systemBy similarity1
Active sitei478Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.375.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 53 (EC:3.4.21.-)
Alternative name(s):
Polyserine protease 3
Short name:
Polyserase-3
Gene namesi
Name:PRSS53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000151006.7.
HGNCiHGNC:34407. PRSS53.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151006.
PharmGKBiPA165450635.

Polymorphism and mutation databases

BioMutaiPRSS53.
DMDMi121941263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000031676324 – 553Serine protease 53Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 78
Disulfide bondi158 ↔ 230
Disulfide bondi187 ↔ 209
Disulfide bondi220 ↔ 249
Disulfide bondi326 ↔ 342
Disulfide bondi444 ↔ 464
Disulfide bondi474 ↔ 502

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ2L4Q9.
PeptideAtlasiQ2L4Q9.
PRIDEiQ2L4Q9.

Expressioni

Tissue specificityi

Predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines.1 Publication

Gene expression databases

BgeeiENSG00000151006.
GenevisibleiQ2L4Q9. HS.

Organism-specific databases

HPAiHPA034955.
HPA034956.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000280606.

Structurei

3D structure databases

ProteinModelPortaliQ2L4Q9.
SMRiQ2L4Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 273Peptidase S1 1Add BLAST250
Domaini294 – 526Peptidase S1 2Add BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00900000140784.
HOGENOMiHOG000060298.
HOVERGENiHBG106755.
InParanoidiQ2L4Q9.
OMAiDEDSCVA.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ2L4Q9.
TreeFamiTF321170.

Family and domain databases

CDDicd00190. Tryp_SPc. 2 hits.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 2 hits.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 2 hits.
SUPFAMiSSF50494. SSF50494. 2 hits.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2L4Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWCWGPVLL IAGATVLMEG LQAAQRACGQ RGPGPPKPQE GNTVPGEWPW
60 70 80 90 100
QASVRRQGAH ICSGSLVADT WVLTAAHCFE KAAATELNSW SVVLGSLQRE
110 120 130 140 150
GLSPGAEEVG VAALQLPRAY NHYSQGSDLA LLQLAHPTTH TPLCLPQPAH
160 170 180 190 200
RFPFGASCWA TGWDQDTSDA PGTLRNLRLR LISRPTCNCI YNQLHQRHLS
210 220 230 240 250
NPARPGMLCG GPQPGVQGPC QGDSGGPVLC LEPDGHWVQA GIISFASSCA
260 270 280 290 300
QEDAPVLLTN TAAHSSWLQA RVQGAAFLAQ SPETPEMSDE DSCVACGSLR
310 320 330 340 350
TAGPQAGAPS PWPWEARLMH QGQLACGGAL VSEEAVLTAA HCFIGRQAPE
360 370 380 390 400
EWSVGLGTRP EEWGLKQLIL HGAYTHPEGG YDMALLLLAQ PVTLGASLRP
410 420 430 440 450
LCLPYPDHHL PDGERGWVLG RARPGAGISS LQTVPVTLLG PRACSRLHAA
460 470 480 490 500
PGGDGSPILP GMVCTSAVGE LPSCEGLSGA PLVHEVRGTW FLAGLHSFGD
510 520 530 540 550
ACQGPARPAV FTALPAYEDW VSSLDWQVYF AEEPEPEAEP GSCLANISQP

TSC
Length:553
Mass (Da):58,410
Last modified:March 7, 2006 - v1
Checksum:i8464159A3E65AFA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627035 mRNA. Translation: CAF25304.1.
CCDSiCCDS42153.1.
RefSeqiNP_001034592.1. NM_001039503.2.
UniGeneiHs.569575.

Genome annotation databases

EnsembliENST00000280606; ENSP00000280606; ENSG00000151006.
GeneIDi339105.
KEGGihsa:339105.
UCSCiuc002eaq.4. human.

Similar proteinsi

Entry informationi

Entry nameiPRS53_HUMAN
AccessioniPrimary (citable) accession number: Q2L4Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 7, 2006
Last modified: October 25, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families