Q2L4Q9 (PRS53_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine protease 53
EC=3.4.21.-

Alternative name(s):
Polyserine protease 3
Short name=Polyserase-3

Gene names

Name:

PRSS53

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator. Ref.1
Subcellular location	Secreted Ref.1.
Tissue specificity	Predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines. Ref.1
Sequence similarities	Belongs to the peptidase S1 family. Contains 2 peptidase S1 domains.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 553	530	Serine protease 53		PRO_0000316763
Regions
	Domain	24 – 273	250	Peptidase S1 1
	Domain	294 – 526	233	Peptidase S1 2
Sites
	Active site	77	1	Charge relay system By similarity
	Active site	128	1	Charge relay system By similarity
	Active site	224	1	Charge relay system By similarity
	Active site	341	1	Charge relay system By similarity
	Active site	382	1	Charge relay system By similarity
	Active site	478	1	Charge relay system By similarity
Amino acid modifications
	Disulfide bond	62 ↔ 78		By similarity
	Disulfide bond	158 ↔ 230		By similarity
	Disulfide bond	187 ↔ 209		By similarity
	Disulfide bond	220 ↔ 249		By similarity
	Disulfide bond	326 ↔ 342		By similarity
	Disulfide bond	444 ↔ 464		By similarity
	Disulfide bond	474 ↔ 502		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2L4Q9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 8464159A3E65AFA7	FASTA	553	58,410
	10 20 30 40 50 60 MKWCWGPVLL IAGATVLMEG LQAAQRACGQ RGPGPPKPQE GNTVPGEWPW QASVRRQGAH 70 80 90 100 110 120 ICSGSLVADT WVLTAAHCFE KAAATELNSW SVVLGSLQRE GLSPGAEEVG VAALQLPRAY 130 140 150 160 170 180 NHYSQGSDLA LLQLAHPTTH TPLCLPQPAH RFPFGASCWA TGWDQDTSDA PGTLRNLRLR 190 200 210 220 230 240 LISRPTCNCI YNQLHQRHLS NPARPGMLCG GPQPGVQGPC QGDSGGPVLC LEPDGHWVQA 250 260 270 280 290 300 GIISFASSCA QEDAPVLLTN TAAHSSWLQA RVQGAAFLAQ SPETPEMSDE DSCVACGSLR 310 320 330 340 350 360 TAGPQAGAPS PWPWEARLMH QGQLACGGAL VSEEAVLTAA HCFIGRQAPE EWSVGLGTRP 370 380 390 400 410 420 EEWGLKQLIL HGAYTHPEGG YDMALLLLAQ PVTLGASLRP LCLPYPDHHL PDGERGWVLG 430 440 450 460 470 480 RARPGAGISS LQTVPVTLLG PRACSRLHAA PGGDGSPILP GMVCTSAVGE LPSCEGLSGA 490 500 510 520 530 540 PLVHEVRGTW FLAGLHSFGD ACQGPARPAV FTALPAYEDW VSSLDWQVYF AEEPEPEAEP 550 GSCLANISQP TSC

References

[1]

"Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain." Cal S., Peinado J.R., Llamazares M., Quesada V., Moncada-Pazos A., Garabaya C., Lopez-Otin C. BMC Biochem. 7:9-9(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ627035 mRNA. Translation: CAF25304.1.
IPI	IPI00553224.
RefSeq	NP_001034592.1. NM_001039503.2.
UniGene	Hs.569575.
3D structure databases
HSSP	HSSP built from PDB template 1ZPZ based on UniProtKB P03951.
ProteinModelPortal	Q2L4Q9.
ModBase	Search...
Protein family/group databases
MEROPS	S01.374.
Polymorphism databases
DMDM	121941263.
Proteomic databases
PaxDb	Q2L4Q9.
PRIDE	Q2L4Q9.
Protocols and materials databases
DNASU	339105.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280606; ENSP00000280606; ENSG00000151006.
GeneID	339105.
KEGG	hsa:339105.
UCSC	uc002eaq.3. human.
Organism-specific databases
CTD	339105.
GeneCards	GC16M031094.
HGNC	HGNC:34407. PRSS53.
HPA	HPA034956.
MIM	610561. gene.
neXtProt	NX_Q2L4Q9.
PharmGKB	PA165450635.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000060298.
HOVERGEN	HBG106755.
InParanoid	Q2L4Q9.
OMA	LPGMVCT.
OrthoDB	EOG43N7CC.
Gene expression databases
Bgee	Q2L4Q9.
Genevestigator	Q2L4Q9.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 2 hits. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 2 hits. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 2 hits.
PROSITE	PS50240. TRYPSIN_DOM. 2 hits. PS00134. TRYPSIN_HIS. 2 hits. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PRSS53. human.
GenomeRNAi	339105.
NextBio	97232.
SOURCE	Search...

Entry information

Entry name

PRS53_HUMAN

Accession

Primary (citable) accession number: Q2L4Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.