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Protein

Serine protease 53

Gene

PRSS53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei77 – 771Charge relay systemBy similarity
Active sitei128 – 1281Charge relay systemBy similarity
Active sitei224 – 2241Charge relay systemBy similarity
Active sitei341 – 3411Charge relay systemBy similarity
Active sitei382 – 3821Charge relay systemBy similarity
Active sitei478 – 4781Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.375.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 53 (EC:3.4.21.-)
Alternative name(s):
Polyserine protease 3
Short name:
Polyserase-3
Gene namesi
Name:PRSS53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:34407. PRSS53.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165450635.

Polymorphism and mutation databases

BioMutaiPRSS53.
DMDMi121941263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 553530Serine protease 53PRO_0000316763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 78PROSITE-ProRule annotation
Disulfide bondi158 ↔ 230PROSITE-ProRule annotation
Disulfide bondi187 ↔ 209PROSITE-ProRule annotation
Disulfide bondi220 ↔ 249PROSITE-ProRule annotation
Disulfide bondi326 ↔ 342PROSITE-ProRule annotation
Disulfide bondi444 ↔ 464PROSITE-ProRule annotation
Disulfide bondi474 ↔ 502PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ2L4Q9.
PRIDEiQ2L4Q9.

Expressioni

Tissue specificityi

Predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines.1 Publication

Gene expression databases

BgeeiQ2L4Q9.
GenevisibleiQ2L4Q9. HS.

Organism-specific databases

HPAiHPA034956.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000280606.

Structurei

3D structure databases

ProteinModelPortaliQ2L4Q9.
SMRiQ2L4Q9. Positions 42-272, 303-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 273250Peptidase S1 1PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 526233Peptidase S1 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 2 peptidase S1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00840000129691.
HOGENOMiHOG000060298.
HOVERGENiHBG106755.
InParanoidiQ2L4Q9.
OMAiEVRGTWF.
OrthoDBiEOG7RNK07.
PhylomeDBiQ2L4Q9.
TreeFamiTF321170.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 2 hits.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 2 hits.
PROSITEiPS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2L4Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWCWGPVLL IAGATVLMEG LQAAQRACGQ RGPGPPKPQE GNTVPGEWPW
60 70 80 90 100
QASVRRQGAH ICSGSLVADT WVLTAAHCFE KAAATELNSW SVVLGSLQRE
110 120 130 140 150
GLSPGAEEVG VAALQLPRAY NHYSQGSDLA LLQLAHPTTH TPLCLPQPAH
160 170 180 190 200
RFPFGASCWA TGWDQDTSDA PGTLRNLRLR LISRPTCNCI YNQLHQRHLS
210 220 230 240 250
NPARPGMLCG GPQPGVQGPC QGDSGGPVLC LEPDGHWVQA GIISFASSCA
260 270 280 290 300
QEDAPVLLTN TAAHSSWLQA RVQGAAFLAQ SPETPEMSDE DSCVACGSLR
310 320 330 340 350
TAGPQAGAPS PWPWEARLMH QGQLACGGAL VSEEAVLTAA HCFIGRQAPE
360 370 380 390 400
EWSVGLGTRP EEWGLKQLIL HGAYTHPEGG YDMALLLLAQ PVTLGASLRP
410 420 430 440 450
LCLPYPDHHL PDGERGWVLG RARPGAGISS LQTVPVTLLG PRACSRLHAA
460 470 480 490 500
PGGDGSPILP GMVCTSAVGE LPSCEGLSGA PLVHEVRGTW FLAGLHSFGD
510 520 530 540 550
ACQGPARPAV FTALPAYEDW VSSLDWQVYF AEEPEPEAEP GSCLANISQP

TSC
Length:553
Mass (Da):58,410
Last modified:March 7, 2006 - v1
Checksum:i8464159A3E65AFA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627035 mRNA. Translation: CAF25304.1.
CCDSiCCDS42153.1.
RefSeqiNP_001034592.1. NM_001039503.2.
UniGeneiHs.569575.

Genome annotation databases

EnsembliENST00000280606; ENSP00000280606; ENSG00000151006.
GeneIDi339105.
KEGGihsa:339105.
UCSCiuc002eaq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627035 mRNA. Translation: CAF25304.1.
CCDSiCCDS42153.1.
RefSeqiNP_001034592.1. NM_001039503.2.
UniGeneiHs.569575.

3D structure databases

ProteinModelPortaliQ2L4Q9.
SMRiQ2L4Q9. Positions 42-272, 303-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000280606.

Protein family/group databases

MEROPSiS01.375.

Polymorphism and mutation databases

BioMutaiPRSS53.
DMDMi121941263.

Proteomic databases

PaxDbiQ2L4Q9.
PRIDEiQ2L4Q9.

Protocols and materials databases

DNASUi339105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280606; ENSP00000280606; ENSG00000151006.
GeneIDi339105.
KEGGihsa:339105.
UCSCiuc002eaq.4. human.

Organism-specific databases

CTDi339105.
GeneCardsiPRSS53.
HGNCiHGNC:34407. PRSS53.
HPAiHPA034956.
MIMi610561. gene.
neXtProtiNX_Q2L4Q9.
PharmGKBiPA165450635.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00840000129691.
HOGENOMiHOG000060298.
HOVERGENiHBG106755.
InParanoidiQ2L4Q9.
OMAiEVRGTWF.
OrthoDBiEOG7RNK07.
PhylomeDBiQ2L4Q9.
TreeFamiTF321170.

Miscellaneous databases

ChiTaRSiPRSS53. human.
GenomeRNAii339105.
NextBioi97232.
PROiQ2L4Q9.
SOURCEiSearch...

Gene expression databases

BgeeiQ2L4Q9.
GenevisibleiQ2L4Q9. HS.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 2 hits.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 2 hits.
PROSITEiPS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain."
    Cal S., Peinado J.R., Llamazares M., Quesada V., Moncada-Pazos A., Garabaya C., Lopez-Otin C.
    BMC Biochem. 7:9-9(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal liver.

Entry informationi

Entry nameiPRS53_HUMAN
AccessioniPrimary (citable) accession number: Q2L4Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 7, 2006
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.