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Q2L2T2 (Q2L2T2_BORA1) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897 EMBL CAJ48956.1
Ordered Locus Names:BAV1347
OrganismBordetella avium (strain 197N) [Complete proteome] [HAMAP]
Taxonomic identifier360910 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella ›

Protein attributes

Sequence length883 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q2L2T2 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: ED9D0959553B92E1

FASTA88397,906
        10         20         30         40         50         60 
MDSFAKETLP VSLEEEMRRS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMHELNNDWN 

        70         80         90        100        110        120 
RAYKKSARIV GDVIGKYHPH GDQSVYDTIV RMAQDFSMRY MLVDGQGNFG SIDGDNAAAM 

       130        140        150        160        170        180 
RYTEIRLAKI AHELLADIDQ ETVDFGPNYD GSEQEPLLLP SRLPNLLVNG SSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLGEV VEGCLYCLRN PECTIDELLE IIPAPDFPTG GIIYGMVGVR EGYRTGRGRV 

       250        260        270        280        290        300 
IMRAKTHFED MDKGNRQAIV VDAIPYQVNK KTLQERIAEL VNEKKIEGIS DIRDESDKDG 

       310        320        330        340        350        360 
MRLVIELKRG EVPEVVLNNL YKNTQLQDTF GMNLVALVDG QPRLLNLKQL ISYFLQHRRE 

       370        380        390        400        410        420 
VVTRRTVFQL RKARERGHVL EGLAVALANI DDFIAIIKAA PTPPVARQEL MARNWDSSLV 

       430        440        450        460        470        480 
REMLARADGD VVGGRQAFRP EDLPEGFGLQ GDGQYRLSET QAQEILNMRL QRLTGLEQDK 

       490        500        510        520        530        540 
IIGEYKDVMD TIADLLDILA RPERITTIIG EELQAIKAEF SSGAKDSRRS EIELNATELD 

       550        560        570        580        590        600 
TEDLITPMDM VVTMSHGGYI KSQPLSEYRS QKRGGRGKQA TQMKENDWVD QLFIANTHDY 

       610        620        630        640        650        660 
LLCFSNRGRV YWLKVWEVPQ GTRNSRGKPI VNMFPLADGE KITVVLPVKE FSDDHYVFMA 

       670        680        690        700        710        720 
TSRGTVKKTA LSDFSNPRKA GIIAVDLDEG DYLIGADLTD GKHDVMLFSD SGKAVRFDEN 

       730        740        750        760        770        780 
DVRPMGRAAR GVRGMMLEDS QSVIALLVAG DESQSVLTAT ENGYGKRTSI AEYTRHGRGT 

       790        800        810        820        830        840 
KGMIAIQTSS RNGRVVGAVL VNPSDEIMLI TTGGVLVRTR VSEIREMGRA TQGVTLISVD 

       850        860        870        880 
DGSSLSGVRR VAESDADDDE AADAADGSDG ADGVAESTEE PTE

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References

[1]"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 197N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM167904 Genomic DNA. Translation: CAJ48956.1.
RefSeqYP_785869.1. NC_010645.1.

3D structure databases

ProteinModelPortalQ2L2T2.
SMRQ2L2T2. Positions 30-532, 547-853.
ModBaseSearch...

Protein-protein interaction databases

STRING360910.BAV1347.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6267458.
KEGGbav:BAV1347.
PATRIC21128886. VBIBorAvi43433_1366.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2L2T2_BORA1
AccessionPrimary (citable) accession number: Q2L2T2
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info