Q2L2S7 (AROA_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BAV1352

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012412

Sequences

	Sequence		Length	Mass (Da)
	Q2L2S7 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: C1B5674BABF5A4AF	FASTA	439	46,509
	10 20 30 40 50 60 MNALAYLDLP HIRQARGLAA LPGSKSISNR VLLIAALAEG RTEISGLLDS DDTRVMLAAL 70 80 90 100 110 120 RQLGVAVTDL GQGRVAVEGA RRFPAEKAEL FLGNAGTAFR PLTAALALMG GDYRLSGVPR 130 140 150 160 170 180 MHERPIGDLV DALRAWGARI DYLGQAGYPP LHIGRGDIRA DRVRVQGSVS SQFLTALLLA 190 200 210 220 230 240 APIEAGASGR PVTIEVIGEL ISKPYIEITL NLMARYGVNV VRDGWRAFTI EGDARYRSPG 250 260 270 280 290 300 SIAVEGDAST ASYLLALGVL GGGPVRVTGV GEQSIQGDTA FADTLAAMGA NITKGSDWIE 310 320 330 340 350 360 ASGQAVAEGG RIKAFDADFN LIPDAAMTAA TMALFADGPC RLRNIGSWRV KETDRIHAMH 370 380 390 400 410 420 TELAKLGAKV ESGPDWLSLT PPADSDWRDA HIGTWDDHRM AMCFSLAAFG PAAVRILDPG 430 CVSKTFPDYF DVYAGLVSA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ48961.1.
RefSeq	YP_785874.1. NC_010645.1.
3D structure databases
HSSP	HSSP built from PDB template 2BJB based on UniProtKB P22487.
ProteinModelPortal	Q2L2S7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2L2S7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6267905.
GenomeReviews	Gene locus BAV1352 in contig AM167904_GR.
KEGG	bav:BAV1352.
NMPDR	fig|521.1.peg.517.
PATRIC	21128896. VBIBorAvi43433_1371.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	GADIEWG.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV1352-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BORA1

Accession

Primary (citable) accession number: Q2L2S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program