Reviewed, UniProtKB/Swiss-Prot Q2L1P5 (PDXK_BORA1)

Names and origin

Protein names

Recommended name:
    Pyridoxine kinase
    EC=2.7.1.35
Alternative name(s):
    Pyridoxal kinase
    Vitamin B6 kinase
    Pyridoxamine kinase
    PN/PL/PM kinase

Gene names

Name:	pdxK
Ordered Locus Names:	BAV1601

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates By similarity.
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01638
Cofactor	Zinc or magnesium By similarity.
Sequence similarities	Belongs to the pyridoxine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP pyridoxine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP pyridoxal kinase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Pyridoxine kinase HAMAP MF_01638		PRO_0000268831
Regions
	Nucleotide binding	195 – 196	2	ATP By similarity
Sites
	Binding site	23	1	Substrate By similarity
	Binding site	136	1	Substrate By similarity
	Binding site	234	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2L1P5-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 92AD82068C41703E	FASTA	296	31,504
	10 20 30 40 50 60 MSSGQGYVAS GRPLLFDVVS VQSQVVYGHV GNNVAAPALR AHGLHPGIVP TVLLSNTPHY 70 80 90 100 110 120 PTLHGGALPL SWFEGYLQDL QARGALQALR AILVGYLGSA EQARVLGRWI ARIREVHPQV 130 140 150 160 170 180 LVIVDPVMGD DDHGLYVTEG LAEASRECLV PQAHGLTPNS FELGLLTGCE VGRVDQAVAA 190 200 210 220 230 240 ARRLLAQGLR WVVVTSAAQQ DCPPGQVQLL AVTASQAHLL RHQRVDTAPK GTGDLFCAEL 250 260 270 280 290 TAHLLAGASL ERAVEASSRY LVQALACTRL ADSAELLMPS RDPAQAQAVQ WIPLEN

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ49211.1.
RefSeq	YP_786122.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6265510.
GenomeReviews	Gene locus BAV1601 in contig AM167904_GR.
KEGG	bav:BAV1601.
NMPDR	fig|521.1.peg.2726.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2L1P5.
OMA	Q2L1P5. RARMLVS.
Family and domain databases
HAMAP	MF_01638. [Tree]
InterPro	IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. [Graphical view]
Pfam	PF08543. Phos_pyr_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXK_BORA1

Accession

Primary (citable) accession number: Q2L1P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)